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B1YEL4 (B1YEL4_EXIS2) Unreviewed, UniProtKB/TrEMBL

Last modified May 29, 2013. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
CTP synthase HAMAP-Rule MF_01227
EC=6.3.4.2 HAMAP-Rule MF_01227
Alternative name(s):
CTP synthetase HAMAP-Rule MF_01227
UTP--ammonia ligase HAMAP-Rule MF_01227
Gene names
Name:pyrG HAMAP-Rule MF_01227
Ordered Locus Names:Exig_2734 EMBL ACB62182.1
OrganismExiguobacterium sibiricum (strain DSM 17290 / JCM 13490 / 255-15) [Complete proteome] [HAMAP] EMBL ACB62182.1
Taxonomic identifier262543 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacilli › Bacillales › Bacillales Family XII. Incertae Sedis › Exiguobacterium ›

Protein attributes

Sequence length531 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen By similarity. HAMAP-Rule MF_01227 SAAS SAAS017456

Catalytic activity

ATP + UTP + NH3 = ADP + phosphate + CTP. HAMAP-Rule MF_01227 SAAS SAAS017456

Enzyme regulation

Allosterically activated by GTP, when glutamine is the substrate. Inhibited by CTP By similarity. HAMAP-Rule MF_01227

Pathway

Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2. HAMAP-Rule MF_01227 SAAS SAAS017456

Subunit structure

Homotetramer By similarity. HAMAP-Rule MF_01227

Sequence similarities

Belongs to the CTP synthase family. HAMAP-Rule MF_01227

Contains 1 glutamine amidotransferase type-1 domain. HAMAP-Rule MF_01227 SAAS SAAS017456

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain292 – 531240Glutamine amidotransferase type-1 By similarity HAMAP-Rule MF_01227
Region1 – 254254Aminator domain By similarity HAMAP-Rule MF_01227

Sites

Active site3811Nucleophile By similarity HAMAP-Rule MF_01227
Active site5071 By similarity HAMAP-Rule MF_01227
Active site5091 By similarity HAMAP-Rule MF_01227

Sequences

Sequence LengthMass (Da)Tools
B1YEL4 [UniParc].

Last modified May 20, 2008. Version 1.
Checksum: 12C5C28B4396465A

FASTA53159,205
        10         20         30         40         50         60 
MTKYIFVTGG VVSSLGKGIT AASLARLLKN RGLNVTIQKF DPYINIDPGT MSPYQHGEVF 

        70         80         90        100        110        120 
VTDDGAETDL DLGHYERFID INLSQNANVT SGRIYSTVLK KERRGDYNGG TVQVIPHITN 

       130        140        150        160        170        180 
EIKDRVFRAG KETGADVVIT EIGGTVGDIE SLPFIEAIRQ VKNDIGKENV MYVHCTLVPY 

       190        200        210        220        230        240 
LAAAGELKTK PTQHSVKELR SYGIQPDIIV LRAEHDVPQE MKDKIALFCD TRPEAVIEAK 

       250        260        270        280        290        300 
DASTLYEVPL NLQRQGMDQL VCDYFKFDTP AADMTAWKQL VHTVTHLEKK TKIALVGKYV 

       310        320        330        340        350        360 
ELRDAYISVA EALKHAGFAF NSDIEIDWIN AEDVTRDNVQ ELLGSANGIL VPGGFGERGI 

       370        380        390        400        410        420 
EGKIEATRFA RENNVPFFGI CLGMQLATVE FARNVLNLEG AHSAEIDPAT PYPIIDLLPE 

       430        440        450        460        470        480 
QKDIEDLGGT LRLGLYPCKL EDGSKARAAY SSELVYERHR HRYEFGNEFR EQFEANGMIF 

       490        500        510        520        530 
SGTSPDGRLV EIIEIPEHKW FVACQFHPEL ISRPERPQAL FHDFIQASLG E

« Hide

References

[1]"Complete sequence of chromosome of Exiguobacterium sibiricum 255-15."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Kiss H., Chertkov O., Monk C., Brettin T., Detter J.C., Han C., Kuske C.R., Schmutz J., Larimer F. expand/collapse author list , Land M., Hauser L., Kyrpides N., Mikhailova N., Vishnivetskaya T., Rodrigues D.F., Gilichinsky D., Tiedje J., Richardson P.
Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 17290 / JCM 13490 / 255-15.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001022 Genomic DNA. Translation: ACB62182.1.
RefSeqYP_001815199.1. NC_010556.1.

3D structure databases

ProteinModelPortalB1YEL4.
SMRB1YEL4. Positions 2-530.
ModBaseSearch...

Protein-protein interaction databases

STRING262543.Exig_2734.

Protein family/group databases

MEROPSC26.964.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACB62182; ACB62182; Exig_2734.
GeneID6174311.
KEGGesi:Exig_2734.
PATRIC32139114. VBIExiSib53410_2778.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0504.
HOGENOMHOG000077515.
KOK01937.
OMATNEIKDR.
ProtClustDBPRK05380.

Enzyme and pathway databases

BioCycESIB262543:GHBP-2816-MONOMER.
UniPathwayUPA00159; UER00277.

Family and domain databases

HAMAPMF_01227. PyrG.
InterProIPR004468. CTP_synthase.
IPR017456. CTP_synthase_N.
IPR017926. GATASE.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERPTHR11550. PTHR11550. 1 hit.
PfamPF06418. CTP_synth_N. 1 hit.
PF00117. GATase. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR00337. PyrG. 1 hit.
PROSITEPS51273. GATASE_TYPE_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameB1YEL4_EXIS2
AccessionPrimary (citable) accession number: B1YEL4
Entry history
Integrated into UniProtKB/TrEMBL: May 20, 2008
Last sequence update: May 20, 2008
Last modified: May 29, 2013
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info