B1YDM9 (B1YDM9_THENV) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Delta-aminolevulinic acid dehydratase RuleBase RU000515
EC=4.2.1.24 RuleBase RU000515

Gene names

Ordered Locus Names:

Tneu_0957

Organism

Thermoproteus neutrophilus (strain DSM 2338 / JCM 9278 / V24Sta) [Complete proteome] [HAMAP]

Taxonomic identifier

444157 [NCBI]

Taxonomic lineage

Archaea › Crenarchaeota › Thermoprotei › Thermoproteales › Thermoproteaceae › Thermoproteus

Protein attributes

Sequence length	336 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	2 5-aminolevulinate = porphobilinogen + 2 H2O. RuleBase RU000515
Subunit structure	Homooctamer By similarity. RuleBase RU000515 PIRSR PIRSR001415-3
Sequence similarities	Belongs to the ALADH family. RuleBase RU004161

Ontologies

Keywords
Biological process	Porphyrin biosynthesis RuleBase RU000515
Ligand	Magnesium PIRSR PIRSR001415-5 Metal-binding PIRSR PIRSR001415-3 Zinc PIRSR PIRSR001415-3
Molecular function	Lyase RuleBase RU000515 EMBL ACB39892.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	porphyrin-containing compound biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW porphobilinogen synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	202	1	Schiff-base intermediate with substrate By similarity PIRSR PIRSR001415-1
	Active site	255	1	Schiff-base intermediate with substrate By similarity PIRSR PIRSR001415-1
	Metal binding	123	1	Zinc; catalytic By similarity PIRSR PIRSR001415-3
	Metal binding	125	1	Zinc; catalytic By similarity PIRSR PIRSR001415-3
	Metal binding	133	1	Zinc; catalytic By similarity PIRSR PIRSR001415-3
	Metal binding	240	1	Magnesium By similarity PIRSR PIRSR001415-5
	Binding site	212	1	Substrate 1 By similarity PIRSR PIRSR001415-2
	Binding site	224	1	Substrate 1 By similarity PIRSR PIRSR001415-2
	Binding site	282	1	Substrate 2 By similarity PIRSR PIRSR001415-2
	Binding site	321	1	Substrate 2 By similarity PIRSR PIRSR001415-2

Sequences

	Sequence		Length	Mass (Da)
	B1YDM9 [UniParc]. Last modified May 20, 2008. Version 1. Checksum: 03F59D7C0D33935F	FASTA	336	36,806
	10 20 30 40 50 60 MRYPAARPRR LRTSKIVRDA VAETALDPGD FIYPIFVKEG PGPEAIPTMP GQHRWPVGEE 70 80 90 100 110 120 LVKHVEEALA LGVNKFILFG VVPEEQKDPH GSRGYDPEGP VPKALRLLKE TFGDKALLFA 130 140 150 160 170 180 DVCLCEYTDH GHCGVVETAG GRWHVDNDKT IKLYAKEALV YADAGADFVA PSGMMDGQVA 190 200 210 220 230 240 EIRKALDAHG FHHVGIMAYS AKYASAFYGP FRTAAASAPK FGDRRTYQMD PRNAHEALKE 250 260 270 280 290 300 VAMDLEEGAD IVMVKPALAY LDVIRLVKQH YPWAPLAAYN VSGEYAMVKA AAAAGYIDEK 310 320 330 VTTLEILTAI KRAGADLILT YHAPEAAKWL KDGTPF

References

[1]

"Complete sequence of Thermoproteus neutrophilus V24Sta." Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Sims D., Brettin T., Detter J.C., Han C., Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L. , Kyrpides N., Mikhailova N., Biddle J.F., Zhang Z., Fitz-Gibbon S.T., Lowe T.M., Saltikov C., House C.H., Richardson P. Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 2338 / JCM 9278 / V24Sta.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001014 Genomic DNA. Translation: ACB39892.1.
RefSeq	YP_001794338.1. NC_010525.1.
3D structure databases
ProteinModelPortal	B1YDM9.
ModBase	Search...
Protein-protein interaction databases
STRING	B1YDM9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6164519.
GenomeReviews	Gene locus Tneu_0957 in contig CP001014_GR.
KEGG	tne:Tneu_0957.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG285270.
OMA	HAPEAAK.
ProtClustDB	PRK09283.
Family and domain databases
InterPro	IPR013785. Aldolase_TIM. IPR001731. Porphobilinogen_synth. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01698.
PANTHER	PTHR11458. AlaD_dehydratase. 1 hit.
Pfam	PF00490. ALAD. 1 hit. [Graphical view]
PIRSF	PIRSF001415. Porphbilin_synth. 1 hit.
PRINTS	PR00144. DALDHYDRTASE.
SMART	SM01004. ALAD. 1 hit. [Graphical view]
PROSITE	PS00169. D_ALA_DEHYDRATASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

B1YDM9_THENV

Accession

Primary (citable) accession number: B1YDM9

Entry history

Integrated into UniProtKB/TrEMBL:	May 20, 2008
Last sequence update:	May 20, 2008
Last modified:	January 25, 2012
This is version 23 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)