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B1YD64 (AROB_THENV) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 25. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-dehydroquinate synthase
EC=4.2.3.4
Gene names
Name:aroB
Ordered Locus Names:Tneu_0788
OrganismThermoproteus neutrophilus (strain DSM 2338 / JCM 9278 / V24Sta) [Complete proteome] [HAMAP]
Taxonomic identifier444157 [NCBI]
Taxonomic lineageArchaea › Crenarchaeota › Thermoprotei › Thermoproteales › Thermoproteaceae › Thermoproteus

Protein attributes

Sequence length343 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate = 3-dehydroquinate + phosphate. HAMAP MF_00110

Cofactor

Divalent metal cations By similarity. HAMAP MF_00110

NAD By similarity. HAMAP MF_00110

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7. HAMAP MF_00110

Subunit structure

Monomer By similarity. HAMAP MF_00110

Subcellular location

Cytoplasm By similarity HAMAP MF_00110.

Sequence similarities

Belongs to the dehydroquinate synthase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
   Cellular componentCytoplasm
   LigandNAD
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processaromatic amino acid family biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular function3-dehydroquinate synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3433433-dehydroquinate synthase HAMAP MF_00110
PRO_1000117500

Sequences

Sequence LengthMass (Da)Tools
B1YD64 [UniParc].

Last modified May 20, 2008. Version 1.
Checksum: F187D2B4E1CCFDAD

FASTA34337,148
        10         20         30         40         50         60 
MRRFFYRHSR GVTEVVVGSG LQYGDYVERP VVLAEEGLRP PIPGAPTLAL RGGEEVKSLE 

        70         80         90        100        110        120 
VLTKVYGFLK EVGADRSTTL VAVGGGALLD LATFAAGTYM RGIRLVHIPT TLLAMVDAAL 

       130        140        150        160        170        180 
GGKGAVDWGP VKNLIGVFYQ PAAILCDLSW LGTLPERVYR SAFAEVVKYG LALDGDFYSW 

       190        200        210        220        230        240 
VRENAKALLA RDGGALEYAV YRSLQLKAGV VEVDEFEERG VRQVLNVGHT VGHAVERVLG 

       250        260        270        280        290        300 
LLHGEAVAVG MVAELRLSSE LGYLRESHVA EAAEVLSSLG LPTSVKATEQ QLAEAAALVK 

       310        320        330        340 
FDKKRRGGHI YIPLVVRPGR WILEKIAVEE VEKAVRYVLR QGG

« Hide

References

[1]"Complete sequence of Thermoproteus neutrophilus V24Sta."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Sims D., Brettin T., Detter J.C., Han C., Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L. expand/collapse author list , Kyrpides N., Mikhailova N., Biddle J.F., Zhang Z., Fitz-Gibbon S.T., Lowe T.M., Saltikov C., House C.H., Richardson P.
Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 2338 / JCM 9278 / V24Sta.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001014 Genomic DNA. Translation: ACB39727.1.
RefSeqYP_001794173.1. NC_010525.1.

3D structure databases

ProteinModelPortalB1YD64.
ModBaseSearch...

Protein-protein interaction databases

STRINGB1YD64.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6164698.
GenomeReviewsGene locus Tneu_0788 in contig CP001014_GR.
KEGGtne:Tneu_0788.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG632303.
OMAMADEHEQ.
ProtClustDBPRK00002.

Family and domain databases

HAMAPMF_00110. DHQ_synthase.
[Tree]
InterProIPR016037. DHQ_synth_AroB.
[Graphical view]
KOK01735.
PANTHERPTHR21090:SF1. DHQ_synth_AroB. 1 hit.
PIRSFPIRSF001455. DHQ_synth. 1 hit.
ProtoNetSearch...

Entry information

Entry nameAROB_THENV
AccessionPrimary (citable) accession number: B1YD64
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: May 20, 2008
Last modified: January 25, 2012
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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