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Protein

tRNA (guanine(26)-N(2))-dimethyltransferase

Gene

trm1

Organism
Pyrobaculum neutrophilum (strain DSM 2338 / JCM 9278 / V24Sta) (Thermoproteus neutrophilus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups.UniRule annotation

Catalytic activityi

2 S-adenosyl-L-methionine + guanine(26) in tRNA = 2 S-adenosyl-L-homocysteine + N2-dimethylguanine(26) in tRNA.UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionMethyltransferase, RNA-binding, Transferase, tRNA-binding
Biological processtRNA processing
LigandS-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine(26)-N(2))-dimethyltransferaseUniRule annotation (EC:2.1.1.216UniRule annotation)
Alternative name(s):
tRNA 2,2-dimethylguanosine-26 methyltransferaseUniRule annotation
tRNA(guanine-26,N(2)-N(2)) methyltransferaseUniRule annotation
tRNA(m(2,2)G26)dimethyltransferaseUniRule annotation
Gene namesi
Name:trm1UniRule annotation
Ordered Locus Names:Tneu_0683
OrganismiPyrobaculum neutrophilum (strain DSM 2338 / JCM 9278 / V24Sta) (Thermoproteus neutrophilus)
Taxonomic identifieri444157 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiThermoprotealesThermoproteaceaePyrobaculum
Proteomesi
  • UP000001694 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001149831 – 351tRNA (guanine(26)-N(2))-dimethyltransferaseAdd BLAST351

Proteomic databases

PRIDEiB1YCV9

Interactioni

Protein-protein interaction databases

STRINGi444157.Tneu_0683

Structurei

3D structure databases

ProteinModelPortaliB1YCV9
SMRiB1YCV9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 350Trm1 methyltransferaseUniRule annotationAdd BLAST347

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01219 Archaea
COG1867 LUCA
HOGENOMiHOG000229931
KOiK00555
OMAiVFYNPVM
OrthoDBiPOG093Z0BNY

Family and domain databases

HAMAPiMF_00290 tRNA_dimethyltr_TRM1, 1 hit
InterProiView protein in InterPro
IPR029063 SAM-dependent_MTases
IPR002905 Trm1
IPR022923 TRM1_arc_bac
PANTHERiPTHR10631 PTHR10631, 2 hits
PfamiView protein in Pfam
PF02005 TRM, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit
PROSITEiView protein in PROSITE
PS51626 SAM_MT_TRM1, 1 hit

Sequencei

Sequence statusi: Complete.

B1YCV9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLVLRREGA VQFYAPDPQR YGSIYSAPVF YNPAMEKNRT LSVLLLRTLG
60 70 80 90 100
GGLTVCEPLS GTGVRGIRYA VESKAVARLV LNDISRDAAE LIKKNLELNG
110 120 130 140 150
VDGEVYNDDA NVLLHRLKNV CDVVDIDPFG SPAPYIHAAF RALRDEGLLC
160 170 180 190 200
ATATDTAVLV GRYPRKCLRR YWSTVRKTPF YIELGLRNLV GFIARVAASE
210 220 230 240 250
DFSIRPLMSY WEGHYFRTCV AVARGARDAD DALQNVGYVV YRRGMRQTTQ
260 270 280 290 300
LPDESSSGPL WLGPLGDPLI MHQMAQHGVY SDFLGVLEQE YSIEAPWHYR
310 320 330 340 350
LPEFAVEGVS PTLAEALDLL RRSGIYATAT HMAKDGFKAD AGYGEVKRAL

F
Length:351
Mass (Da):39,045
Last modified:May 20, 2008 - v1
Checksum:i4669560313B152E6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001014 Genomic DNA Translation: ACB39622.1

Genome annotation databases

EnsemblBacteriaiACB39622; ACB39622; Tneu_0683
KEGGitne:Tneu_0683

Similar proteinsi

Entry informationi

Entry nameiTRM1_PYRNV
AccessioniPrimary (citable) accession number: B1YCV9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: May 20, 2008
Last modified: May 23, 2018
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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