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Protein

Nicotinamide-nucleotide adenylyltransferase

Gene

Tneu_0591

Organism
Pyrobaculum neutrophilum (strain DSM 2338 / JCM 9278 / V24Sta) (Thermoproteus neutrophilus)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + nicotinamide ribonucleotide = diphosphate + NAD+.UniRule annotation

Pathwayi: NAD(+) biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes NAD(+) from nicotinamide D-ribonucleotide.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Nicotinamide-nucleotide adenylyltransferase (Tneu_1430), Nicotinamide-nucleotide adenylyltransferase (Tneu_0591)
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes NAD(+) from nicotinamide D-ribonucleotide, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Keywords - Ligandi

ATP-binding, NAD, Nucleotide-binding

Enzyme and pathway databases

BioCyciPNEU444157:G12XQ-575-MONOMER.
UniPathwayiUPA00253; UER00600.

Names & Taxonomyi

Protein namesi
Recommended name:
Nicotinamide-nucleotide adenylyltransferaseUniRule annotation (EC:2.7.7.1UniRule annotation)
Alternative name(s):
NAD(+) diphosphorylaseUniRule annotation
NAD(+) pyrophosphorylaseUniRule annotation
NMN adenylyltransferaseUniRule annotation
Gene namesi
Ordered Locus Names:Tneu_0591
OrganismiPyrobaculum neutrophilum (strain DSM 2338 / JCM 9278 / V24Sta) (Thermoproteus neutrophilus)
Taxonomic identifieri444157 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiThermoprotealesThermoproteaceaePyrobaculum
Proteomesi
  • UP000001694 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001007571 – 178Nicotinamide-nucleotide adenylyltransferaseAdd BLAST178

Interactioni

Protein-protein interaction databases

STRINGi444157.Tneu_0591.

Structurei

3D structure databases

ProteinModelPortaliB1YCL7.
SMRiB1YCL7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the archaeal NMN adenylyltransferase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00972. Archaea.
COG1056. LUCA.
HOGENOMiHOG000108858.
KOiK00952.
OMAiVYTGNPF.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00243. NMN_adenylyltr. 1 hit.
InterProiIPR004821. Cyt_trans-like.
IPR006418. NMN_Atrans_arc.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF01467. CTP_transf_like. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01527. arch_NMN_Atrans. 1 hit.
TIGR00125. cyt_tran_rel. 1 hit.

Sequencei

Sequence statusi: Complete.

B1YCL7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKRALFPGRF QPPHWGHVYA IREVLKEVDE LVVAVGSAQF NYIAKDPFTA
60 70 80 90 100
GERIWMLREA LREAGVDLSR VCTIPIPNVE NNLEWLGRVK SYAPPFQVVY
110 120 130 140 150
TGNPYVALLF REAGYEVRQQ PMYQRERYSS TRVRELLMRG DPQWEELVPR
160 170
SVAEIIKAIG GAERLRIAAA GEAEPHRW
Length:178
Mass (Da):20,479
Last modified:May 20, 2008 - v1
Checksum:i7597756023664B0E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001014 Genomic DNA. Translation: ACB39530.1.

Genome annotation databases

EnsemblBacteriaiACB39530; ACB39530; Tneu_0591.
KEGGitne:Tneu_0591.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001014 Genomic DNA. Translation: ACB39530.1.

3D structure databases

ProteinModelPortaliB1YCL7.
SMRiB1YCL7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi444157.Tneu_0591.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACB39530; ACB39530; Tneu_0591.
KEGGitne:Tneu_0591.

Phylogenomic databases

eggNOGiarCOG00972. Archaea.
COG1056. LUCA.
HOGENOMiHOG000108858.
KOiK00952.
OMAiVYTGNPF.

Enzyme and pathway databases

UniPathwayiUPA00253; UER00600.
BioCyciPNEU444157:G12XQ-575-MONOMER.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00243. NMN_adenylyltr. 1 hit.
InterProiIPR004821. Cyt_trans-like.
IPR006418. NMN_Atrans_arc.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF01467. CTP_transf_like. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01527. arch_NMN_Atrans. 1 hit.
TIGR00125. cyt_tran_rel. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNADM_PYRNV
AccessioniPrimary (citable) accession number: B1YCL7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: May 20, 2008
Last modified: November 2, 2016
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.