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B1YAX4

- SYE_PYRNV

UniProt

B1YAX4 - SYE_PYRNV

Protein

Glutamate--tRNA ligase

Gene

gltX

Organism
Pyrobaculum neutrophilum (strain DSM 2338 / JCM 9278 / V24Sta) (Thermoproteus neutrophilus)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 41 (01 Oct 2014)
      Sequence version 1 (20 May 2008)
      Previous versions | rss
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    Functioni

    Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

    Catalytic activityi

    ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. glutamate-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. glutamyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciTNEU444157:GHL2-1801-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamate--tRNA ligaseUniRule annotation (EC:6.1.1.17UniRule annotation)
    Alternative name(s):
    Glutamyl-tRNA synthetaseUniRule annotation
    Short name:
    GluRSUniRule annotation
    Gene namesi
    Name:gltXUniRule annotation
    Ordered Locus Names:Tneu_1756
    OrganismiPyrobaculum neutrophilum (strain DSM 2338 / JCM 9278 / V24Sta) (Thermoproteus neutrophilus)
    Taxonomic identifieri444157 [NCBI]
    Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiThermoprotealesThermoproteaceaePyrobaculum
    ProteomesiUP000001694: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 570570Glutamate--tRNA ligasePRO_1000090116Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi444157.Tneu_1756.

    Structurei

    3D structure databases

    ProteinModelPortaliB1YAX4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi107 – 11711"HIGH" regionAdd
    BLAST

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0008.
    HOGENOMiHOG000073585.
    KOiK01885.
    OMAiAFRIIDT.

    Family and domain databases

    Gene3Di1.10.1160.10. 1 hit.
    3.40.50.620. 2 hits.
    HAMAPiMF_00022_A. Glu_tRNA_synth_A.
    InterProiIPR004526. Glu-tRNA-synth_arc/euk.
    IPR000924. Glu/Gln-tRNA-synth.
    IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
    IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
    IPR020059. Glu/Gln-tRNA-synth_Ib_codon-bd.
    IPR022888. Glu_tRNA_synth_arc.
    IPR011035. Ribosomal_L25/Gln-tRNA_synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PANTHERiPTHR10119. PTHR10119. 1 hit.
    PfamiPF00749. tRNA-synt_1c. 1 hit.
    PF03950. tRNA-synt_1c_C. 1 hit.
    [Graphical view]
    PRINTSiPR00987. TRNASYNTHGLU.
    SUPFAMiSSF50715. SSF50715. 1 hit.
    TIGRFAMsiTIGR00463. gltX_arch. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B1YAX4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNIEDVVLKY ALANAVKYGG RADVKAVMAK IMAEVPDLRP RAREVRQLVE    50
    AVVAKVNSMQ PEEQLRLLRE RWPEALEERR VEQRRPGIES LPELPNVRGG 100
    VVVRFAPNPD FVLHLGSARP AILNYAYRMR YGGRFILRFE DTDPRTKRPL 150
    VSDEVNAYEA IREDLRWLGV RWDEEHIQSR RMEIYYDHAR MLLSMGAAYV 200
    DLCRPEEWRR LRNAGRACPH RGQSPEEALE LWDRMLRGDF GEGEAVVRIK 250
    TDLSHPDPSV RDWVAFRVID TSKTPHPLTG DRYVVWPTYN FAVSIDDHLM 300
    GVTHVLRAQE HSVNTVKQSY VFKHFGWEQP VTIHFGRLRI EGASLSKSKL 350
    KALRVRYDDV SLPTLAGLRS RGILPEAIWE LILTVGIKPS DTTVALSNLF 400
    ALNRKRVEPA ANRYMFVTEP VKLVFESDRE LVAKIPLHPS YRERGERVYK 450
    LGPGRVEVYV SSRDVRPGAV VRLMELANVE VLEVGGGAAR GRLHSLELEA 500
    ARRVGAPIVQ WVADPVEVRV VKPVAVGKKV EEVGLGERAL EAVEEGAYLQ 550
    FFRYGFVKKV GRLDFVYVHD 570
    Length:570
    Mass (Da):65,052
    Last modified:May 20, 2008 - v1
    Checksum:iA8CEDDCB043E24C2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001014 Genomic DNA. Translation: ACB40674.1.
    RefSeqiYP_001795120.1. NC_010525.1.

    Genome annotation databases

    EnsemblBacteriaiACB40674; ACB40674; Tneu_1756.
    GeneIDi6165414.
    KEGGitne:Tneu_1756.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001014 Genomic DNA. Translation: ACB40674.1 .
    RefSeqi YP_001795120.1. NC_010525.1.

    3D structure databases

    ProteinModelPortali B1YAX4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 444157.Tneu_1756.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACB40674 ; ACB40674 ; Tneu_1756 .
    GeneIDi 6165414.
    KEGGi tne:Tneu_1756.

    Phylogenomic databases

    eggNOGi COG0008.
    HOGENOMi HOG000073585.
    KOi K01885.
    OMAi AFRIIDT.

    Enzyme and pathway databases

    BioCyci TNEU444157:GHL2-1801-MONOMER.

    Family and domain databases

    Gene3Di 1.10.1160.10. 1 hit.
    3.40.50.620. 2 hits.
    HAMAPi MF_00022_A. Glu_tRNA_synth_A.
    InterProi IPR004526. Glu-tRNA-synth_arc/euk.
    IPR000924. Glu/Gln-tRNA-synth.
    IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
    IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
    IPR020059. Glu/Gln-tRNA-synth_Ib_codon-bd.
    IPR022888. Glu_tRNA_synth_arc.
    IPR011035. Ribosomal_L25/Gln-tRNA_synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    PANTHERi PTHR10119. PTHR10119. 1 hit.
    Pfami PF00749. tRNA-synt_1c. 1 hit.
    PF03950. tRNA-synt_1c_C. 1 hit.
    [Graphical view ]
    PRINTSi PR00987. TRNASYNTHGLU.
    SUPFAMi SSF50715. SSF50715. 1 hit.
    TIGRFAMsi TIGR00463. gltX_arch. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 2338 / JCM 9278 / V24Sta.

    Entry informationi

    Entry nameiSYE_PYRNV
    AccessioniPrimary (citable) accession number: B1YAX4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: May 20, 2008
    Last modified: October 1, 2014
    This is version 41 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3