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B1YAS9

- SYL_PYRNV

UniProt

B1YAS9 - SYL_PYRNV

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Pyrobaculum neutrophilum (strain DSM 2338 / JCM 9278 / V24Sta) (Thermoproteus neutrophilus)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 45 (01 Oct 2014)
      Sequence version 1 (20 May 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei641 – 6411ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciTNEU444157:GHL2-204-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:Tneu_0203
    OrganismiPyrobaculum neutrophilum (strain DSM 2338 / JCM 9278 / V24Sta) (Thermoproteus neutrophilus)
    Taxonomic identifieri444157 [NCBI]
    Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiThermoprotealesThermoproteaceaePyrobaculum
    ProteomesiUP000001694: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 945945Leucine--tRNA ligasePRO_1000091375Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi444157.Tneu_0203.

    Structurei

    3D structure databases

    ProteinModelPortaliB1YAS9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi43 – 5311"HIGH" regionAdd
    BLAST
    Motifi638 – 6425"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000216620.
    KOiK01869.
    OMAiHAPFDYL.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_A. Leu_tRNA_synth_A.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR020791. Leu-tRNA-lgase_arc.
    IPR004493. Leu-tRNA-synth_Ia_arc/euk.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    [Graphical view]
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 2 hits.
    TIGRFAMsiTIGR00395. leuS_arch. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B1YAS9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSELSRFFIE LGERWQRRWR EARVFEPEPA PGVPKYFITA AYPYPNGAIH    50
    IGHGRTYLVA DVMARFQRHL GRSVLFPMGF HYTGTPILTI AEVIAAGDKA 100
    VMEEYMELYG VPEEEIKKMG DPLYLARYFH GQSKRAMERF GLSIDWTREF 150
    TTIDPEYQRF IQWQFEKLRK KGLIVRGRHP VGWCPRHSMP VGAHDTKDDK 200
    EPDIGQWTLV YFTDSEGLTF PTATLRPETV LGVTNLWINP DAEYVVAEFD 250
    GRRAVVSRDA AYRLSFQVGV KILREARGRE FVGRMVQNPV TGEWVPVYEA 300
    RFVDPKVGTG VVMSVPAHAP YDYAALRDLG TVKLIPLIRV EGYGDYPAKE 350
    VVERMGIKSQ ADPALEDATK EVYSAEYARG VMREDVAERV GAHLEEPARS 400
    MLRAVFKMYF AGRPVREARE FIARWLTEAR LGGVMYDIMN KPVYCRCGTE 450
    IVVKVLEDQW FINYGESRWK EAARELVKEM SIVPGEARAQ FLATIDWLDK 500
    RACARTRGLG TPLPWSSGWV IESLSDSTIY MAFYTVVKRI RQFGIRPEQL 550
    TEEFWDFVFL GQGSADEVSK KTGVPVEALK AIREEFEYWY PLDSRNSGKD 600
    LIPNHLTFFI FNHVAIFPRE KWPRQIVANG WVLREGEKMS KSKRNVLPLD 650
    RAVEMYGPDP LRATLALAAE VEQDLDFRDA EARRNAQQLM SIYTLAQRLV 700
    QGAEERPPTW VDQWLVAEIS RVLERAREAY EKVRVRQAAV EVLYNAKAVF 750
    DQYLAMVEKP SRQAVEAAKA WAVAMEPLVP HLAEELWATL GGAGFAALAP 800
    WPKLRAEPAA LLAKRYVDML IEDVKNIPAF GQGAKRVVIY VNRSFAWVKA 850
    ALAGDVKTVI GAGVPPQQAK KVVDLVKTLG DEMRGLIAAV DHFDELEALR 900
    SYRNYVEKAL GAPVEIYGAD DPAAPDLGGK KRVALPLKPG IYVEK 945
    Length:945
    Mass (Da):107,198
    Last modified:May 20, 2008 - v1
    Checksum:iCC177301AAFCDF38
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001014 Genomic DNA. Translation: ACB39158.1.
    RefSeqiYP_001793604.1. NC_010525.1.

    Genome annotation databases

    EnsemblBacteriaiACB39158; ACB39158; Tneu_0203.
    GeneIDi6165044.
    KEGGitne:Tneu_0203.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001014 Genomic DNA. Translation: ACB39158.1 .
    RefSeqi YP_001793604.1. NC_010525.1.

    3D structure databases

    ProteinModelPortali B1YAS9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 444157.Tneu_0203.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACB39158 ; ACB39158 ; Tneu_0203 .
    GeneIDi 6165044.
    KEGGi tne:Tneu_0203.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000216620.
    KOi K01869.
    OMAi HAPFDYL.

    Enzyme and pathway databases

    BioCyci TNEU444157:GHL2-204-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_A. Leu_tRNA_synth_A.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR020791. Leu-tRNA-lgase_arc.
    IPR004493. Leu-tRNA-synth_Ia_arc/euk.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 2 hits.
    TIGRFAMsi TIGR00395. leuS_arch. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 2338 / JCM 9278 / V24Sta.

    Entry informationi

    Entry nameiSYL_PYRNV
    AccessioniPrimary (citable) accession number: B1YAS9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: May 20, 2008
    Last modified: October 1, 2014
    This is version 45 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3