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B1YAS9

- SYL_PYRNV

UniProt

B1YAS9 - SYL_PYRNV

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Pyrobaculum neutrophilum (strain DSM 2338 / JCM 9278 / V24Sta) (Thermoproteus neutrophilus)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei641 – 6411ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciTNEU444157:GHL2-204-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Tneu_0203
OrganismiPyrobaculum neutrophilum (strain DSM 2338 / JCM 9278 / V24Sta) (Thermoproteus neutrophilus)
Taxonomic identifieri444157 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiThermoprotealesThermoproteaceaePyrobaculum
ProteomesiUP000001694: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 945945Leucine--tRNA ligasePRO_1000091375Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi444157.Tneu_0203.

Structurei

3D structure databases

ProteinModelPortaliB1YAS9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi43 – 5311"HIGH" regionAdd
BLAST
Motifi638 – 6425"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000216620.
KOiK01869.
OMAiHAPFDYL.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_A. Leu_tRNA_synth_A.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR020791. Leu-tRNA-lgase_arc.
IPR004493. Leu-tRNA-synth_Ia_arc/euk.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
[Graphical view]
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 2 hits.
TIGRFAMsiTIGR00395. leuS_arch. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B1YAS9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSELSRFFIE LGERWQRRWR EARVFEPEPA PGVPKYFITA AYPYPNGAIH
60 70 80 90 100
IGHGRTYLVA DVMARFQRHL GRSVLFPMGF HYTGTPILTI AEVIAAGDKA
110 120 130 140 150
VMEEYMELYG VPEEEIKKMG DPLYLARYFH GQSKRAMERF GLSIDWTREF
160 170 180 190 200
TTIDPEYQRF IQWQFEKLRK KGLIVRGRHP VGWCPRHSMP VGAHDTKDDK
210 220 230 240 250
EPDIGQWTLV YFTDSEGLTF PTATLRPETV LGVTNLWINP DAEYVVAEFD
260 270 280 290 300
GRRAVVSRDA AYRLSFQVGV KILREARGRE FVGRMVQNPV TGEWVPVYEA
310 320 330 340 350
RFVDPKVGTG VVMSVPAHAP YDYAALRDLG TVKLIPLIRV EGYGDYPAKE
360 370 380 390 400
VVERMGIKSQ ADPALEDATK EVYSAEYARG VMREDVAERV GAHLEEPARS
410 420 430 440 450
MLRAVFKMYF AGRPVREARE FIARWLTEAR LGGVMYDIMN KPVYCRCGTE
460 470 480 490 500
IVVKVLEDQW FINYGESRWK EAARELVKEM SIVPGEARAQ FLATIDWLDK
510 520 530 540 550
RACARTRGLG TPLPWSSGWV IESLSDSTIY MAFYTVVKRI RQFGIRPEQL
560 570 580 590 600
TEEFWDFVFL GQGSADEVSK KTGVPVEALK AIREEFEYWY PLDSRNSGKD
610 620 630 640 650
LIPNHLTFFI FNHVAIFPRE KWPRQIVANG WVLREGEKMS KSKRNVLPLD
660 670 680 690 700
RAVEMYGPDP LRATLALAAE VEQDLDFRDA EARRNAQQLM SIYTLAQRLV
710 720 730 740 750
QGAEERPPTW VDQWLVAEIS RVLERAREAY EKVRVRQAAV EVLYNAKAVF
760 770 780 790 800
DQYLAMVEKP SRQAVEAAKA WAVAMEPLVP HLAEELWATL GGAGFAALAP
810 820 830 840 850
WPKLRAEPAA LLAKRYVDML IEDVKNIPAF GQGAKRVVIY VNRSFAWVKA
860 870 880 890 900
ALAGDVKTVI GAGVPPQQAK KVVDLVKTLG DEMRGLIAAV DHFDELEALR
910 920 930 940
SYRNYVEKAL GAPVEIYGAD DPAAPDLGGK KRVALPLKPG IYVEK
Length:945
Mass (Da):107,198
Last modified:May 20, 2008 - v1
Checksum:iCC177301AAFCDF38
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001014 Genomic DNA. Translation: ACB39158.1.
RefSeqiYP_001793604.1. NC_010525.1.

Genome annotation databases

EnsemblBacteriaiACB39158; ACB39158; Tneu_0203.
GeneIDi6165044.
KEGGitne:Tneu_0203.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001014 Genomic DNA. Translation: ACB39158.1 .
RefSeqi YP_001793604.1. NC_010525.1.

3D structure databases

ProteinModelPortali B1YAS9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 444157.Tneu_0203.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACB39158 ; ACB39158 ; Tneu_0203 .
GeneIDi 6165044.
KEGGi tne:Tneu_0203.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000216620.
KOi K01869.
OMAi HAPFDYL.

Enzyme and pathway databases

BioCyci TNEU444157:GHL2-204-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_A. Leu_tRNA_synth_A.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR020791. Leu-tRNA-lgase_arc.
IPR004493. Leu-tRNA-synth_Ia_arc/euk.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
[Graphical view ]
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 2 hits.
TIGRFAMsi TIGR00395. leuS_arch. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 2338 / JCM 9278 / V24Sta.

Entry informationi

Entry nameiSYL_PYRNV
AccessioniPrimary (citable) accession number: B1YAS9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: May 20, 2008
Last modified: October 29, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3