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B1YAS9 (SYL_PYRNV) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Leucine--tRNA ligase

EC=6.1.1.4
Alternative name(s):
Leucyl-tRNA synthetase
Short name=LeuRS
Gene names
Name:leuS
Ordered Locus Names:Tneu_0203
OrganismPyrobaculum neutrophilum (strain DSM 2338 / JCM 9278 / V24Sta) (Thermoproteus neutrophilus) [Complete proteome] [HAMAP]
Taxonomic identifier444157 [NCBI]
Taxonomic lineageArchaeaCrenarchaeotaThermoproteiThermoprotealesThermoproteaceaePyrobaculum

Protein attributes

Sequence length945 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu). HAMAP-Rule MF_00049

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00049.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processleucyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

aminoacyl-tRNA editing activity

Inferred from electronic annotation. Source: InterPro

leucine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 945945Leucine--tRNA ligase HAMAP-Rule MF_00049
PRO_1000091375

Regions

Motif43 – 5311"HIGH" region HAMAP-Rule MF_00049
Motif638 – 6425"KMSKS" region HAMAP-Rule MF_00049

Sites

Binding site6411ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
B1YAS9 [UniParc].

Last modified May 20, 2008. Version 1.
Checksum: CC177301AAFCDF38

FASTA945107,198
        10         20         30         40         50         60 
MSELSRFFIE LGERWQRRWR EARVFEPEPA PGVPKYFITA AYPYPNGAIH IGHGRTYLVA 

        70         80         90        100        110        120 
DVMARFQRHL GRSVLFPMGF HYTGTPILTI AEVIAAGDKA VMEEYMELYG VPEEEIKKMG 

       130        140        150        160        170        180 
DPLYLARYFH GQSKRAMERF GLSIDWTREF TTIDPEYQRF IQWQFEKLRK KGLIVRGRHP 

       190        200        210        220        230        240 
VGWCPRHSMP VGAHDTKDDK EPDIGQWTLV YFTDSEGLTF PTATLRPETV LGVTNLWINP 

       250        260        270        280        290        300 
DAEYVVAEFD GRRAVVSRDA AYRLSFQVGV KILREARGRE FVGRMVQNPV TGEWVPVYEA 

       310        320        330        340        350        360 
RFVDPKVGTG VVMSVPAHAP YDYAALRDLG TVKLIPLIRV EGYGDYPAKE VVERMGIKSQ 

       370        380        390        400        410        420 
ADPALEDATK EVYSAEYARG VMREDVAERV GAHLEEPARS MLRAVFKMYF AGRPVREARE 

       430        440        450        460        470        480 
FIARWLTEAR LGGVMYDIMN KPVYCRCGTE IVVKVLEDQW FINYGESRWK EAARELVKEM 

       490        500        510        520        530        540 
SIVPGEARAQ FLATIDWLDK RACARTRGLG TPLPWSSGWV IESLSDSTIY MAFYTVVKRI 

       550        560        570        580        590        600 
RQFGIRPEQL TEEFWDFVFL GQGSADEVSK KTGVPVEALK AIREEFEYWY PLDSRNSGKD 

       610        620        630        640        650        660 
LIPNHLTFFI FNHVAIFPRE KWPRQIVANG WVLREGEKMS KSKRNVLPLD RAVEMYGPDP 

       670        680        690        700        710        720 
LRATLALAAE VEQDLDFRDA EARRNAQQLM SIYTLAQRLV QGAEERPPTW VDQWLVAEIS 

       730        740        750        760        770        780 
RVLERAREAY EKVRVRQAAV EVLYNAKAVF DQYLAMVEKP SRQAVEAAKA WAVAMEPLVP 

       790        800        810        820        830        840 
HLAEELWATL GGAGFAALAP WPKLRAEPAA LLAKRYVDML IEDVKNIPAF GQGAKRVVIY 

       850        860        870        880        890        900 
VNRSFAWVKA ALAGDVKTVI GAGVPPQQAK KVVDLVKTLG DEMRGLIAAV DHFDELEALR 

       910        920        930        940 
SYRNYVEKAL GAPVEIYGAD DPAAPDLGGK KRVALPLKPG IYVEK 

« Hide

References

[1]"Complete sequence of Thermoproteus neutrophilus V24Sta."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Sims D., Brettin T., Detter J.C., Han C., Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L. expand/collapse author list , Kyrpides N., Mikhailova N., Biddle J.F., Zhang Z., Fitz-Gibbon S.T., Lowe T.M., Saltikov C., House C.H., Richardson P.
Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 2338 / JCM 9278 / V24Sta.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001014 Genomic DNA. Translation: ACB39158.1.
RefSeqYP_001793604.1. NC_010525.1.

3D structure databases

ProteinModelPortalB1YAS9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING444157.Tneu_0203.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACB39158; ACB39158; Tneu_0203.
GeneID6165044.
KEGGtne:Tneu_0203.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0495.
HOGENOMHOG000216620.
KOK01869.
OMAHAPFDYL.

Enzyme and pathway databases

BioCycTNEU444157:GHL2-204-MONOMER.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPMF_00049_A. Leu_tRNA_synth_A.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR020791. Leu-tRNA-lgase_arc.
IPR004493. Leu-tRNA-synth_Ia_arc/euk.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PfamPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
[Graphical view]
SUPFAMSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 2 hits.
TIGRFAMsTIGR00395. leuS_arch. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYL_PYRNV
AccessionPrimary (citable) accession number: B1YAS9
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: May 20, 2008
Last modified: May 14, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries