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B1YAS9

- SYL_PYRNV

UniProt

B1YAS9 - SYL_PYRNV

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Protein
Leucine--tRNA ligase
Gene
leuS, Tneu_0203
Organism
Pyrobaculum neutrophilum (strain DSM 2338 / JCM 9278 / V24Sta) (Thermoproteus neutrophilus)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei641 – 6411ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciTNEU444157:GHL2-204-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:Tneu_0203
OrganismiPyrobaculum neutrophilum (strain DSM 2338 / JCM 9278 / V24Sta) (Thermoproteus neutrophilus)
Taxonomic identifieri444157 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiThermoprotealesThermoproteaceaePyrobaculum
ProteomesiUP000001694: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 945945Leucine--tRNA ligaseUniRule annotation
PRO_1000091375Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi444157.Tneu_0203.

Structurei

3D structure databases

ProteinModelPortaliB1YAS9.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi43 – 5311"HIGH" regionUniRule annotation
Add
BLAST
Motifi638 – 6425"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000216620.
KOiK01869.
OMAiHAPFDYL.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_A. Leu_tRNA_synth_A.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR020791. Leu-tRNA-lgase_arc.
IPR004493. Leu-tRNA-synth_Ia_arc/euk.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
[Graphical view]
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 2 hits.
TIGRFAMsiTIGR00395. leuS_arch. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B1YAS9-1 [UniParc]FASTAAdd to Basket

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MSELSRFFIE LGERWQRRWR EARVFEPEPA PGVPKYFITA AYPYPNGAIH    50
IGHGRTYLVA DVMARFQRHL GRSVLFPMGF HYTGTPILTI AEVIAAGDKA 100
VMEEYMELYG VPEEEIKKMG DPLYLARYFH GQSKRAMERF GLSIDWTREF 150
TTIDPEYQRF IQWQFEKLRK KGLIVRGRHP VGWCPRHSMP VGAHDTKDDK 200
EPDIGQWTLV YFTDSEGLTF PTATLRPETV LGVTNLWINP DAEYVVAEFD 250
GRRAVVSRDA AYRLSFQVGV KILREARGRE FVGRMVQNPV TGEWVPVYEA 300
RFVDPKVGTG VVMSVPAHAP YDYAALRDLG TVKLIPLIRV EGYGDYPAKE 350
VVERMGIKSQ ADPALEDATK EVYSAEYARG VMREDVAERV GAHLEEPARS 400
MLRAVFKMYF AGRPVREARE FIARWLTEAR LGGVMYDIMN KPVYCRCGTE 450
IVVKVLEDQW FINYGESRWK EAARELVKEM SIVPGEARAQ FLATIDWLDK 500
RACARTRGLG TPLPWSSGWV IESLSDSTIY MAFYTVVKRI RQFGIRPEQL 550
TEEFWDFVFL GQGSADEVSK KTGVPVEALK AIREEFEYWY PLDSRNSGKD 600
LIPNHLTFFI FNHVAIFPRE KWPRQIVANG WVLREGEKMS KSKRNVLPLD 650
RAVEMYGPDP LRATLALAAE VEQDLDFRDA EARRNAQQLM SIYTLAQRLV 700
QGAEERPPTW VDQWLVAEIS RVLERAREAY EKVRVRQAAV EVLYNAKAVF 750
DQYLAMVEKP SRQAVEAAKA WAVAMEPLVP HLAEELWATL GGAGFAALAP 800
WPKLRAEPAA LLAKRYVDML IEDVKNIPAF GQGAKRVVIY VNRSFAWVKA 850
ALAGDVKTVI GAGVPPQQAK KVVDLVKTLG DEMRGLIAAV DHFDELEALR 900
SYRNYVEKAL GAPVEIYGAD DPAAPDLGGK KRVALPLKPG IYVEK 945
Length:945
Mass (Da):107,198
Last modified:May 20, 2008 - v1
Checksum:iCC177301AAFCDF38
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001014 Genomic DNA. Translation: ACB39158.1.
RefSeqiYP_001793604.1. NC_010525.1.

Genome annotation databases

EnsemblBacteriaiACB39158; ACB39158; Tneu_0203.
GeneIDi6165044.
KEGGitne:Tneu_0203.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001014 Genomic DNA. Translation: ACB39158.1 .
RefSeqi YP_001793604.1. NC_010525.1.

3D structure databases

ProteinModelPortali B1YAS9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 444157.Tneu_0203.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACB39158 ; ACB39158 ; Tneu_0203 .
GeneIDi 6165044.
KEGGi tne:Tneu_0203.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000216620.
KOi K01869.
OMAi HAPFDYL.

Enzyme and pathway databases

BioCyci TNEU444157:GHL2-204-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_A. Leu_tRNA_synth_A.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR020791. Leu-tRNA-lgase_arc.
IPR004493. Leu-tRNA-synth_Ia_arc/euk.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
[Graphical view ]
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 2 hits.
TIGRFAMsi TIGR00395. leuS_arch. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 2338 / JCM 9278 / V24Sta.

Entry informationi

Entry nameiSYL_PYRNV
AccessioniPrimary (citable) accession number: B1YAS9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: May 20, 2008
Last modified: May 14, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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