B1YAM9 (HIS1_THENV) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
ATP phosphoribosyltransferase
Short name=ATP-PRT
Short name=ATP-PRTase
EC=2.4.2.17

Gene names

Name:	hisG
Ordered Locus Names:	Tneu_0151

Organism

Thermoproteus neutrophilus (strain DSM 2338 / JCM 9278 / V24Sta) [Complete proteome] [HAMAP]

Taxonomic identifier

444157 [NCBI]

Taxonomic lineage

Archaea › Crenarchaeota › Thermoprotei › Thermoproteales › Thermoproteaceae › Thermoproteus

Protein attributes

Sequence length	282 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity By similarity. HAMAP MF_00079
Catalytic activity	1-(5-phospho-D-ribosyl)-ATP + diphosphate = ATP + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP MF_00079
Cofactor	Magnesium By similarity. HAMAP MF_00079
Enzyme regulation	Feedback inhibited by histidine By similarity. HAMAP MF_00079
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9. HAMAP MF_00079
Subcellular location	Cytoplasm By similarity HAMAP MF_00079.
Sequence similarities	Belongs to the ATP phosphoribosyltransferase family. Long subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Magnesium Metal-binding Nucleotide-binding
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	histidine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATP phosphoribosyltransferase activity Inferred from electronic annotation. Source: EC magnesium ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 282	282	ATP phosphoribosyltransferase HAMAP MF_00079		PRO_1000092756

Sequences

	Sequence		Length	Mass (Da)
	B1YAM9 [UniParc]. Last modified May 20, 2008. Version 1. Checksum: B5BE1A25BB0AAA01	FASTA	282	30,346
	10 20 30 40 50 60 MLLAVPSKGR LQEPTLKLLE AVGIKPLASD ERALVLPTSW PDVNLIKARP EDIPYLVESG 70 80 90 100 110 120 RVWAGVTGHD YVLESGSNVV EALDLEFGRG RLVVAVPKSS GIKSVEELPP GARVATKFVN 130 140 150 160 170 180 IAYNYFAELG KRVRVVKVTG SVEVLPQLGI ADAILDVMAT GTTLEVHGLT PIATVLETSA 190 200 210 220 230 240 RLVVHPEYTS HELTKKLVTF IKGYFAAQGK KMIFLNVPAA RLEAVLSVLP AMEAPSVTKL 250 260 270 280 AKGDIYEVFS VVSEDVLPDL VMKLKNAGAK DIVVTSIEKL IS

References

[1]

"Complete sequence of Thermoproteus neutrophilus V24Sta." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Sims D., Brettin T., Detter J.C., Han C., Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L. , Kyrpides N., Mikhailova N., Biddle J.F., Zhang Z., Fitz-Gibbon S.T., Lowe T.M., Saltikov C., House C.H., Richardson P. Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 2338 / JCM 9278 / V24Sta.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001014 Genomic DNA. Translation: ACB39108.1.
RefSeq	YP_001793554.1. NC_010525.1.
3D structure databases
ProteinModelPortal	B1YAM9.
ModBase	Search...
Protein-protein interaction databases
STRING	B1YAM9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6164786.
GenomeReviews	Gene locus Tneu_0151 in contig CP001014_GR.
KEGG	tne:Tneu_0151.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG391868.
OMA	IMLHAPS.
ProtClustDB	PRK00489.
Family and domain databases
HAMAP	MF_00079. HisG_Long. [Tree]
InterPro	IPR013820. ATP_PRibTrfase_cat. IPR018198. ATP_PRibTrfase_CS. IPR001348. ATP_PRibTrfase_HisG. IPR020621. ATP_PRibTrfase_HisG_long. IPR013115. HisG_C. IPR011322. N-reg_PII-like_a/b. IPR015867. N-reg_PII/ATP_PRibTrfase_C. [Graphical view]
Gene3D	G3DSA:3.30.70.120. PII_glnB. 1 hit.
KO	K00765.
PANTHER	PTHR21403. ATP_phspho_trans. 1 hit.
Pfam	PF01634. HisG. 1 hit. PF08029. HisG_C. 1 hit. [Graphical view]
SUPFAM	SSF54913. N-reg_PII-like_a/b. 1 hit.
TIGRFAMs	TIGR00070. HisG. 1 hit. TIGR03455. HisG_C-term. 1 hit.
PROSITE	PS01316. ATP_P_PHORIBOSYLTR. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HIS1_THENV

Accession

Primary (citable) accession number: B1YAM9

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	May 20, 2008
Last modified:	January 25, 2012
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program