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Protein

Ribonuclease Z

Gene

rnz

Organism
Pyrobaculum neutrophilum (strain DSM 2338 / JCM 9278 / V24Sta) (Thermoproteus neutrophilus)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.UniRule annotation

Catalytic activityi

Endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 2 Zn2+ ions.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi64Zinc 1; catalyticUniRule annotation1
Metal bindingi66Zinc 1; catalyticUniRule annotation1
Active sitei68Proton acceptorUniRule annotation1
Metal bindingi68Zinc 2; catalyticUniRule annotation1
Metal bindingi69Zinc 2; catalyticUniRule annotation1
Metal bindingi124Zinc 1; catalyticUniRule annotation1
Metal bindingi191Zinc 1; catalyticUniRule annotation1
Metal bindingi191Zinc 2; catalyticUniRule annotation1
Metal bindingi250Zinc 2; catalyticUniRule annotation1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Hydrolase, Nuclease

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease ZUniRule annotation (EC:3.1.26.11UniRule annotation)
Short name:
RNase ZUniRule annotation
Alternative name(s):
tRNA 3 endonucleaseUniRule annotation
tRNase ZUniRule annotation
Gene namesi
Name:rnzUniRule annotation
Ordered Locus Names:Tneu_1723
OrganismiPyrobaculum neutrophilum (strain DSM 2338 / JCM 9278 / V24Sta) (Thermoproteus neutrophilus)
Taxonomic identifieri444157 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiThermoprotealesThermoproteaceaePyrobaculum
Proteomesi
  • UP000001694 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001880021 – 287Ribonuclease ZAdd BLAST287

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi444157.Tneu_1723.

Structurei

3D structure databases

ProteinModelPortaliB1YAJ2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RNase Z family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00501. Archaea.
COG1234. LUCA.
HOGENOMiHOG000272419.
KOiK00784.
OMAiQWDVGYK.

Family and domain databases

Gene3Di3.60.15.10. 2 hits.
HAMAPiMF_01818. RNase_Z_BN. 1 hit.
InterProiIPR001279. Metallo-B-lactamas.
IPR013471. RNase_Z/BN.
[Graphical view]
PfamiPF12706. Lactamase_B_2. 1 hit.
[Graphical view]
SUPFAMiSSF56281. SSF56281. 1 hit.

Sequencei

Sequence statusi: Complete.

B1YAJ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLLKLVFLG TGGAVPRSDR TLPAIYLEDW LGHRFLLDAG EGAQYRLLQI
60 70 80 90 100
GVSPASLTAV AITHQHEDHT LGLPGLVITS RFLGGRTAVL APRSMHKALE
110 120 130 140 150
ALGVEVMDSY GGDRLRVSCV EVCHTVDACG WLFQWDVGYK LDLSKAAGLP
160 170 180 190 200
RWALTSLIRG SPVEVGGRLI KPEDVAEPGH KRLRRLLYTG DTAPCPEMWR
210 220 230 240 250
KVGEVDVLIH EATFADDVEP QKAHEEGHST VADAVEAAKA LNAGVLILTH
260 270 280
VSSRYPDKRR HRELAASVKP PPHVYVPEDF DTVLVRL
Length:287
Mass (Da):31,402
Last modified:May 20, 2008 - v1
Checksum:i92B6AAF4F1FCB3D5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001014 Genomic DNA. Translation: ACB40641.1.

Genome annotation databases

EnsemblBacteriaiACB40641; ACB40641; Tneu_1723.
KEGGitne:Tneu_1723.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001014 Genomic DNA. Translation: ACB40641.1.

3D structure databases

ProteinModelPortaliB1YAJ2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi444157.Tneu_1723.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACB40641; ACB40641; Tneu_1723.
KEGGitne:Tneu_1723.

Phylogenomic databases

eggNOGiarCOG00501. Archaea.
COG1234. LUCA.
HOGENOMiHOG000272419.
KOiK00784.
OMAiQWDVGYK.

Family and domain databases

Gene3Di3.60.15.10. 2 hits.
HAMAPiMF_01818. RNase_Z_BN. 1 hit.
InterProiIPR001279. Metallo-B-lactamas.
IPR013471. RNase_Z/BN.
[Graphical view]
PfamiPF12706. Lactamase_B_2. 1 hit.
[Graphical view]
SUPFAMiSSF56281. SSF56281. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRNZ_PYRNV
AccessioniPrimary (citable) accession number: B1YAJ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: May 20, 2008
Last modified: November 2, 2016
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.