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B1Y9Q9

- B1Y9Q9_PYRNV

UniProt

B1Y9Q9 - B1Y9Q9_PYRNV

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Protein
Submitted name: Orotidine 5'-phosphate decarboxylase
Gene
Tneu_0023
Organism
Pyrobaculum neutrophilum (strain DSM 2338 / JCM 9278 / V24Sta) (Thermoproteus neutrophilus)
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi82 – 821Nickel 1Imported
Metal bindingi82 – 821Nickel 2Imported
Metal bindingi83 – 831Nickel 1Imported
Metal bindingi83 – 831Nickel 2Imported
Binding sitei107 – 1071Chloride; via amide nitrogen
Binding sitei179 – 1791Sulfate; via amide nitrogen

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. orotidine-5'-phosphate decarboxylase activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Metal-bindingImported, NickelImported

Enzyme and pathway databases

BioCyciTNEU444157:GHL2-23-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Orotidine 5'-phosphate decarboxylaseImported
Gene namesi
Ordered Locus Names:Tneu_0023Imported
OrganismiPyrobaculum neutrophilum (strain DSM 2338 / JCM 9278 / V24Sta) (Thermoproteus neutrophilus)Imported
Taxonomic identifieri444157 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiThermoprotealesThermoproteaceaePyrobaculum
ProteomesiUP000001694: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi444157.Tneu_0023.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4DF0X-ray1.50A/B1-202[»]
4DF1X-ray1.90A/B1-202[»]
ProteinModelPortaliB1Y9Q9.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni96 – 983Sulfate binding

Phylogenomic databases

eggNOGiCOG0284.
HOGENOMiHOG000226069.
KOiK01591.
OMAiYVLAKMT.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTiSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.

Sequencei

Sequence statusi: Complete.

B1Y9Q9-1 [UniParc]FASTAAdd to Basket

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MAANLPLVVA LDTEVLKAID VAKRLKGAVA GFKVGWDLIF EGGISIVGEI    50
ARYGNVIVDL KIADVPHVAS RVVEKLVNRG ACCVIVHGFL HPSLPRGQHV 100
YVLVKMTAPT IYDEMWEKLL NSVQDVRGFV LPGNQPEVVA QARKRIGCSY 150
RIISPGIGPQ GGRPGAAIEA GADFEIVGRY VLEDPARISQ WAQYRPTCFE 200
TP 202
Length:202
Mass (Da):21,927
Last modified:May 20, 2008 - v1
Checksum:i8039512D14714DE5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001014 Genomic DNA. Translation: ACB38981.1.
RefSeqiWP_012349403.1. NC_010525.1.
YP_001793427.1. NC_010525.1.

Genome annotation databases

EnsemblBacteriaiACB38981; ACB38981; Tneu_0023.
GeneIDi6166266.
KEGGitne:Tneu_0023.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001014 Genomic DNA. Translation: ACB38981.1 .
RefSeqi WP_012349403.1. NC_010525.1.
YP_001793427.1. NC_010525.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4DF0 X-ray 1.50 A/B 1-202 [» ]
4DF1 X-ray 1.90 A/B 1-202 [» ]
ProteinModelPortali B1Y9Q9.
ModBasei Search...

Protein-protein interaction databases

STRINGi 444157.Tneu_0023.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACB38981 ; ACB38981 ; Tneu_0023 .
GeneIDi 6166266.
KEGGi tne:Tneu_0023.

Phylogenomic databases

eggNOGi COG0284.
HOGENOMi HOG000226069.
KOi K01591.
OMAi YVLAKMT.

Enzyme and pathway databases

BioCyci TNEU444157:GHL2-23-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR013785. Aldolase_TIM.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
Pfami PF00215. OMPdecase. 1 hit.
[Graphical view ]
SMARTi SM00934. OMPdecase. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 2338 / JCM 9278 / V24Sta.
  2. "Crystal structure of orotidine 5'-monophosphate decarboxylase from Thermoproteus neutrophilus complexed with inhibitor BMP."
    Fedorov A.A., Fedorov E.V., Desai B., Gerlt J.A., Almo S.C.
    Submitted (JAN-2012) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS) IN COMPLEX WITH NICKEL.
  3. "Crystal structure of orotidine 5'-monophosphate decarboxylase from Thermoproteus neutrophilus."
    Fedorov A.A., Fedorov E.V., Desai B., Gerlt J.A., Almo S.C.
    Submitted (JAN-2012) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.50 ANGSTROMS) IN COMPLEX WITH NICKEL.

Entry informationi

Entry nameiB1Y9Q9_PYRNV
AccessioniPrimary (citable) accession number: B1Y9Q9
Entry historyi
Integrated into UniProtKB/TrEMBL: May 20, 2008
Last sequence update: May 20, 2008
Last modified: September 3, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported, Complete proteome

External Data

Dasty 3

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