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B1Y9Q9

- B1Y9Q9_PYRNV

UniProt

B1Y9Q9 - B1Y9Q9_PYRNV

Protein
Submitted name:

Orotidine 5'-phosphate decarboxylase

Gene

Tneu_0023

Organism
Pyrobaculum neutrophilum (strain DSM 2338 / JCM 9278 / V24Sta) (Thermoproteus neutrophilus)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 40 (01 Oct 2014)
      Sequence version 1 (20 May 2008)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi82 – 821Nickel 1Imported
    Metal bindingi82 – 821Nickel 2Imported
    Metal bindingi83 – 831Nickel 1Imported
    Metal bindingi83 – 831Nickel 2Imported
    Binding sitei107 – 1071Chloride; via amide nitrogen
    Binding sitei179 – 1791Sulfate; via amide nitrogen

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. orotidine-5'-phosphate decarboxylase activity Source: InterPro

    GO - Biological processi

    1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro

    Enzyme and pathway databases

    BioCyciTNEU444157:GHL2-23-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Orotidine 5'-phosphate decarboxylaseImported
    Gene namesi
    Ordered Locus Names:Tneu_0023Imported
    OrganismiPyrobaculum neutrophilum (strain DSM 2338 / JCM 9278 / V24Sta) (Thermoproteus neutrophilus)Imported
    Taxonomic identifieri444157 [NCBI]
    Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiThermoprotealesThermoproteaceaePyrobaculum
    ProteomesiUP000001694: Chromosome

    Interactioni

    Protein-protein interaction databases

    STRINGi444157.Tneu_0023.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4DF0X-ray1.50A/B1-202[»]
    4DF1X-ray1.90A/B1-202[»]
    ProteinModelPortaliB1Y9Q9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni96 – 983Sulfate binding

    Phylogenomic databases

    eggNOGiCOG0284.
    HOGENOMiHOG000226069.
    KOiK01591.
    OMAiYVLAKMT.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    InterProiIPR013785. Aldolase_TIM.
    IPR001754. OMPdeCOase_dom.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view]
    PfamiPF00215. OMPdecase. 1 hit.
    [Graphical view]
    SMARTiSM00934. OMPdecase. 1 hit.
    [Graphical view]
    SUPFAMiSSF51366. SSF51366. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B1Y9Q9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAANLPLVVA LDTEVLKAID VAKRLKGAVA GFKVGWDLIF EGGISIVGEI    50
    ARYGNVIVDL KIADVPHVAS RVVEKLVNRG ACCVIVHGFL HPSLPRGQHV 100
    YVLVKMTAPT IYDEMWEKLL NSVQDVRGFV LPGNQPEVVA QARKRIGCSY 150
    RIISPGIGPQ GGRPGAAIEA GADFEIVGRY VLEDPARISQ WAQYRPTCFE 200
    TP 202
    Length:202
    Mass (Da):21,927
    Last modified:May 20, 2008 - v1
    Checksum:i8039512D14714DE5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001014 Genomic DNA. Translation: ACB38981.1.
    RefSeqiWP_012349403.1. NC_010525.1.
    YP_001793427.1. NC_010525.1.

    Genome annotation databases

    EnsemblBacteriaiACB38981; ACB38981; Tneu_0023.
    GeneIDi6166266.
    KEGGitne:Tneu_0023.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001014 Genomic DNA. Translation: ACB38981.1 .
    RefSeqi WP_012349403.1. NC_010525.1.
    YP_001793427.1. NC_010525.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4DF0 X-ray 1.50 A/B 1-202 [» ]
    4DF1 X-ray 1.90 A/B 1-202 [» ]
    ProteinModelPortali B1Y9Q9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 444157.Tneu_0023.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACB38981 ; ACB38981 ; Tneu_0023 .
    GeneIDi 6166266.
    KEGGi tne:Tneu_0023.

    Phylogenomic databases

    eggNOGi COG0284.
    HOGENOMi HOG000226069.
    KOi K01591.
    OMAi YVLAKMT.

    Enzyme and pathway databases

    BioCyci TNEU444157:GHL2-23-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    InterProi IPR013785. Aldolase_TIM.
    IPR001754. OMPdeCOase_dom.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view ]
    Pfami PF00215. OMPdecase. 1 hit.
    [Graphical view ]
    SMARTi SM00934. OMPdecase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51366. SSF51366. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 2338 / JCM 9278 / V24StaImported.
    2. "Crystal structure of orotidine 5'-monophosphate decarboxylase from Thermoproteus neutrophilus complexed with inhibitor BMP."
      Fedorov A.A., Fedorov E.V., Desai B., Gerlt J.A., Almo S.C.
      Submitted (JAN-2012) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS).
    3. "Crystal structure of orotidine 5'-monophosphate decarboxylase from Thermoproteus neutrophilus."
      Fedorov A.A., Fedorov E.V., Desai B., Gerlt J.A., Almo S.C.
      Submitted (JAN-2012) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (1.50 ANGSTROMS).

    Entry informationi

    Entry nameiB1Y9Q9_PYRNV
    AccessioniPrimary (citable) accession number: B1Y9Q9
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 20, 2008
    Last sequence update: May 20, 2008
    Last modified: October 1, 2014
    This is version 40 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported, Complete proteomeImported

    External Data

    Dasty 3