ID   B1Y908_PYRNV            Unreviewed;       612 AA.
AC   B1Y908;
DT   20-MAY-2008, integrated into UniProtKB/TrEMBL.
DT   20-MAY-2008, sequence version 1.
DT   27-MAR-2024, entry version 67.
DE   RecName: Full=aldehyde ferredoxin oxidoreductase {ECO:0000256|ARBA:ARBA00012818};
DE            EC=1.2.7.5 {ECO:0000256|ARBA:ARBA00012818};
GN   OrderedLocusNames=Tneu_1310 {ECO:0000313|EMBL:ACB40237.1};
OS   Pyrobaculum neutrophilum (strain DSM 2338 / JCM 9278 / NBRC 100436 /
OS   V24Sta) (Thermoproteus neutrophilus).
OC   Archaea; Thermoproteota; Thermoprotei; Thermoproteales; Thermoproteaceae;
OC   Pyrobaculum.
OX   NCBI_TaxID=444157 {ECO:0000313|EMBL:ACB40237.1, ECO:0000313|Proteomes:UP000001694};
RN   [1] {ECO:0000313|EMBL:ACB40237.1, ECO:0000313|Proteomes:UP000001694}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 2338 / JCM 9278 / NBRC 100436 / V24Sta
RC   {ECO:0000313|Proteomes:UP000001694};
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA   Bruce D., Goodwin L., Pitluck S., Sims D., Brettin T., Detter J.C., Han C.,
RA   Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.,
RA   Mikhailova N., Biddle J.F., Zhang Z., Fitz-Gibbon S.T., Lowe T.M.,
RA   Saltikov C., House C.H., Richardson P.;
RT   "Complete sequence of Thermoproteus neutrophilus V24Sta.";
RL   Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=an aldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = a
CC         carboxylate + 3 H(+) + 2 reduced [2Fe-2S]-[ferredoxin];
CC         Xref=Rhea:RHEA:16421, Rhea:RHEA-COMP:10000, Rhea:RHEA-COMP:10001,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17478,
CC         ChEBI:CHEBI:29067, ChEBI:CHEBI:33737, ChEBI:CHEBI:33738; EC=1.2.7.5;
CC         Evidence={ECO:0000256|ARBA:ARBA00001714};
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000256|ARBA:ARBA00001966};
CC   -!- SIMILARITY: Belongs to the AOR/FOR family.
CC       {ECO:0000256|ARBA:ARBA00011032}.
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DR   EMBL; CP001014; ACB40237.1; -; Genomic_DNA.
DR   AlphaFoldDB; B1Y908; -.
DR   STRING; 444157.Tneu_1310; -.
DR   KEGG; tne:Tneu_1310; -.
DR   eggNOG; arCOG00707; Archaea.
DR   HOGENOM; CLU_020364_1_0_2; -.
DR   Proteomes; UP000001694; Chromosome.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0033726; F:aldehyde ferredoxin oxidoreductase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009055; F:electron transfer activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.569.10; Aldehyde Ferredoxin Oxidoreductase Protein, subunit A, domain 2; 1.
DR   Gene3D; 1.10.599.10; Aldehyde Ferredoxin Oxidoreductase Protein, subunit A, domain 3; 1.
DR   Gene3D; 3.60.9.10; Aldehyde ferredoxin oxidoreductase, N-terminal domain; 1.
DR   InterPro; IPR013984; Ald_Fedxn_OxRdtase_dom2.
DR   InterPro; IPR013985; Ald_Fedxn_OxRdtase_dom3.
DR   InterPro; IPR013983; Ald_Fedxn_OxRdtase_N.
DR   InterPro; IPR036503; Ald_Fedxn_OxRdtase_N_sf.
DR   InterPro; IPR001203; OxRdtase_Ald_Fedxn_C.
DR   InterPro; IPR036021; Tungsten_al_ferr_oxy-like_C.
DR   PANTHER; PTHR30038; ALDEHYDE FERREDOXIN OXIDOREDUCTASE; 1.
DR   PANTHER; PTHR30038:SF5; ALDEHYDE FERREDOXIN OXIDOREDUCTASE; 1.
DR   Pfam; PF01314; AFOR_C; 1.
DR   Pfam; PF02730; AFOR_N; 1.
DR   SMART; SM00790; AFOR_N; 1.
DR   SUPFAM; SSF48310; Aldehyde ferredoxin oxidoreductase, C-terminal domains; 1.
DR   SUPFAM; SSF56228; Aldehyde ferredoxin oxidoreductase, N-terminal domain; 1.
PE   3: Inferred from homology;
KW   4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW   Iron {ECO:0000256|ARBA:ARBA00023004};
KW   Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW   ECO:0000313|EMBL:ACB40237.1}.
FT   DOMAIN          7..209
FT                   /note="Aldehyde ferredoxin oxidoreductase N-terminal"
FT                   /evidence="ECO:0000259|SMART:SM00790"
SQ   SEQUENCE   612 AA;  66835 MW;  89DB6E63C30B3226 CRC64;
     MDSVAGWQGR LLRVDLTRRK AVVQGLDAAV ARDFIGGRGL AAKILWDELP PGVDPLSPYN
     KLIFAAGPLT GLPGPNFGKL VVAAKSPLTG GYGDGNIGTW AAVNLRKAGY DALVVEGRAE
     KPSYIFIDGD RVEILEAGDL WGLNAWSVEE KLQKIHGRDA AVITIGPAGE NLVRFATVVS
     HKGRSGGRPG MGAVMGSKNL KAVVVKGKGE VPLADKAAYQ RLAVEAVREG SSSPSYGFWM
     RQGTTSTVEW AQEASVLPAY NYSEGQFDDF SKIGGGAVEK LETDLKSCPL CFMACGHWVP
     AESGSVEVDY ENLAMLGSNL GIGDLYKVGE LNRIADVMGM DTISLGNVLG YVMEASERGY
     GDRLGFVVEW GDYEAARQLA LDIAYRRGVG DLLADGVRKV AERIGGQDFA MHVKGLEISA
     YDCHAAPAMA LAYATSPIGA HHKDAWVIAW EVKTDRFGYT RDKAAKVVEL QRIRGGWFET
     FVGCRFPWVE VGLSLDWYPR LFKAATGVDA TPEYFNEVGD RIYALIRAFW VREYGWWSRE
     LDMPPAKWFK EPLTKGPLKG ARLDPEGYGR LLDYYYELRG WDRRGVPRRE TLEKLGLGYV
     AAELERLGLA GG
//