B1Y8N7 (B1Y8N7_THENV) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Thymidine kinase HAMAP MF_00124
EC=2.7.1.21 HAMAP MF_00124

Gene names

Name:	tdk HAMAP MF_00124
Ordered Locus Names:	Tneu_1187

Organism

Thermoproteus neutrophilus (strain DSM 2338 / JCM 9278 / V24Sta) [Complete proteome] [HAMAP]

Taxonomic identifier

444157 [NCBI]

Taxonomic lineage

Archaea › Crenarchaeota › Thermoprotei › Thermoproteales › Thermoproteaceae › Thermoproteus

Protein attributes

Sequence length	184 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + thymidine = ADP + thymidine 5'-phosphate. HAMAP MF_00124
Subunit structure	Homotetramer By similarity. HAMAP MF_00124
Subcellular location	Cytoplasm By similarity HAMAP MF_00124.
Sequence similarities	Belongs to the thymidine kinase family. HAMAP MF_00124

Ontologies

Keywords
Biological process	DNA synthesis HAMAP MF_00124
Cellular component	Cytoplasm HAMAP MF_00124
Ligand	ATP-binding HAMAP MF_00124 Metal-binding HAMAP MF_00124 Nucleotide-binding Zinc HAMAP MF_00124
Molecular function	Kinase HAMAP MF_00124 EMBL ACB40116.1 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	DNA replication Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP thymidine kinase activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Nucleotide binding	7 – 14	8	ATP By similarity HAMAP MF_00124
	Nucleotide binding	83 – 86	4	ATP By similarity HAMAP MF_00124
Sites
	Active site	84	1	Proton acceptor By similarity HAMAP MF_00124
	Metal binding	139	1	Zinc By similarity HAMAP MF_00124
	Metal binding	142	1	Zinc By similarity HAMAP MF_00124
	Metal binding	177	1	Zinc By similarity HAMAP MF_00124
	Metal binding	180	1	Zinc By similarity HAMAP MF_00124

Sequences

	Sequence		Length	Mass (Da)
	B1Y8N7 [UniParc]. Last modified May 20, 2008. Version 1. Checksum: A2D7157281EC5491	FASTA	184	20,034
	10 20 30 40 50 60 MLVAIVGPMF AGKTTELIRR VERYVIAGRR AVVFKPSIDA RYDPASVAAH NGLKLNAVVV 70 80 90 100 110 120 PPDEGGVKAI YKLGQRYDVV AVDEVQFFPP ALADVLNKLA DGRVVIAAGL NLDFRGEPFE 130 140 150 160 170 180 TTARLMAYAD RVISLTAVCK ICGRPATRTQ RLVAGKPAPR DSPRIVVGGV ETYEARCRLH HRVN

References

[1]

"Complete sequence of Thermoproteus neutrophilus V24Sta." Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Sims D., Brettin T., Detter J.C., Han C., Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L. , Kyrpides N., Mikhailova N., Biddle J.F., Zhang Z., Fitz-Gibbon S.T., Lowe T.M., Saltikov C., House C.H., Richardson P. Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 2338 / JCM 9278 / V24Sta.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001014 Genomic DNA. Translation: ACB40116.1.
RefSeq	YP_001794562.1. NC_010525.1.
3D structure databases
ProteinModelPortal	B1Y8N7.
ModBase	Search...
Protein-protein interaction databases
STRING	B1Y8N7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6165439.
GenomeReviews	Gene locus Tneu_1187 in contig CP001014_GR.
KEGG	tne:Tneu_1187.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG522108.
OMA	RVERYVI.
ProtClustDB	PRK04296.
Family and domain databases
HAMAP	MF_00124. Thymidine_kinase. [Tree]
InterPro	IPR001267. Thymidine_kinase. IPR020633. Thymidine_kinase_CS. IPR020634. Thymidine_kinase_subgr. [Graphical view]
KO	K00857.
PANTHER	PTHR11441. TK_cell. 1 hit.
Pfam	PF00265. TK. 1 hit. [Graphical view]
PIRSF	PIRSF035805. TK_cell. 1 hit.
PROSITE	PS00603. TK_CELLULAR_TYPE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

B1Y8N7_THENV

Accession

Primary (citable) accession number: B1Y8N7

Entry history

Integrated into UniProtKB/TrEMBL:	May 20, 2008
Last sequence update:	May 20, 2008
Last modified:	December 14, 2011
This is version 24 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)