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B1Y8G2

- GSA_LEPCP

UniProt

B1Y8G2 - GSA_LEPCP

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Protein
Glutamate-1-semialdehyde 2,1-aminomutase
Gene
hemL, Lcho_3974
Organism
Leptothrix cholodnii (strain ATCC 51168 / LMG 8142 / SP-6) (Leptothrix discophora (strain SP-6))
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-4-amino-5-oxopentanoate = 5-aminolevulinate.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. glutamate-1-semialdehyde 2,1-aminomutase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: InterPro
  3. transaminase activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Porphyrin biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciLCHO395495:GHYL-4027-MONOMER.
UniPathwayiUPA00251; UER00317.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate-1-semialdehyde 2,1-aminomutase (EC:5.4.3.8)
Short name:
GSA
Alternative name(s):
Glutamate-1-semialdehyde aminotransferase
Short name:
GSA-AT
Gene namesi
Name:hemL
Ordered Locus Names:Lcho_3974
OrganismiLeptothrix cholodnii (strain ATCC 51168 / LMG 8142 / SP-6) (Leptothrix discophora (strain SP-6))
Taxonomic identifieri395495 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesLeptothrix
ProteomesiUP000001693: Chromosome

Subcellular locationi

Cytoplasm Reviewed prediction UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 437437Glutamate-1-semialdehyde 2,1-aminomutaseUniRule annotation
PRO_1000121900Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei274 – 2741N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi395495.Lcho_3974.

Structurei

3D structure databases

ProteinModelPortaliB1Y8G2.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0001.
HOGENOMiHOG000020210.
KOiK01845.
OMAiLMAHIAP.
OrthoDBiEOG6QVRHN.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPiMF_00375. HemL_aminotrans_3.
InterProiIPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 1 hit.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR00713. hemL. 1 hit.

Sequencei

Sequence statusi: Complete.

B1Y8G2-1 [UniParc]FASTAAdd to Basket

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MATPVSSNAE LFERAQRSIP GGVNSPVRAF RAVGGTPRFI ARAQGAYMWD    50
AEGKQYIDYI GSWGPMILGH GHPAVLAAVQ KAATEGFSFG APTEREVELA 100
ETILALVPSC EQIRLVSSGT EAAMSAIRLA RGATGRSKLI KFEGCYHGHA 150
DALLVKAGSG LATFGNPTSA GVPPEVVQHT LVLTYNDIEQ LEEAFKIHGP 200
ELACVMIEPI AGNMNFVRAT VPFMKRIREL CTQHGALLVF DEVMCGFRVA 250
LGSAQSLYAQ AIPGFAPDVS VFGKVIGGGM PLAAFGASRK IMSLLAPLGP 300
VYQAGTLSGN PVATACGLAT LREISQPGFF EALGARTRRL VDGLSAAAAD 350
AGVPFVGDCQ GGMFGFFFPR NRGEGLPQNY ATVMATDQAR FNSFFHGLLD 400
RGVYLAPALY EAGFVSAAHS DADIDATVAA ARAALQP 437
Length:437
Mass (Da):45,914
Last modified:May 20, 2008 - v1
Checksum:i73820CCFF1406AA9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001013 Genomic DNA. Translation: ACB36228.1.
RefSeqiYP_001792993.1. NC_010524.1.

Genome annotation databases

EnsemblBacteriaiACB36228; ACB36228; Lcho_3974.
GeneIDi6161961.
KEGGilch:Lcho_3974.
PATRICi22398417. VBILepCho83238_4024.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001013 Genomic DNA. Translation: ACB36228.1 .
RefSeqi YP_001792993.1. NC_010524.1.

3D structure databases

ProteinModelPortali B1Y8G2.
ModBasei Search...

Protein-protein interaction databases

STRINGi 395495.Lcho_3974.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACB36228 ; ACB36228 ; Lcho_3974 .
GeneIDi 6161961.
KEGGi lch:Lcho_3974.
PATRICi 22398417. VBILepCho83238_4024.

Phylogenomic databases

eggNOGi COG0001.
HOGENOMi HOG000020210.
KOi K01845.
OMAi LMAHIAP.
OrthoDBi EOG6QVRHN.

Enzyme and pathway databases

UniPathwayi UPA00251 ; UER00317 .
BioCyci LCHO395495:GHYL-4027-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPi MF_00375. HemL_aminotrans_3.
InterProi IPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
PANTHERi PTHR11986. PTHR11986. 1 hit.
Pfami PF00202. Aminotran_3. 1 hit.
[Graphical view ]
PIRSFi PIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR00713. hemL. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51168 / LMG 8142 / SP-6.

Entry informationi

Entry nameiGSA_LEPCP
AccessioniPrimary (citable) accession number: B1Y8G2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: May 20, 2008
Last modified: May 14, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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