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B1Y823

- PNP_LEPCP

UniProt

B1Y823 - PNP_LEPCP

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Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Leptothrix cholodnii (strain ATCC 51168 / LMG 8142 / SP-6) (Leptothrix discophora (strain SP-6))
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi488 – 4881MagnesiumUniRule annotation
Metal bindingi494 – 4941MagnesiumUniRule annotation

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
  4. RNA binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. mRNA catabolic process Source: UniProtKB-HAMAP
  2. RNA processing Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Enzyme and pathway databases

BioCyciLCHO395495:GHYL-1515-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
Alternative name(s):
Polynucleotide phosphorylaseUniRule annotation
Short name:
PNPaseUniRule annotation
Gene namesi
Name:pnpUniRule annotation
Ordered Locus Names:Lcho_1497
OrganismiLeptothrix cholodnii (strain ATCC 51168 / LMG 8142 / SP-6) (Leptothrix discophora (strain SP-6))
Taxonomic identifieri395495 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesLeptothrix
ProteomesiUP000001693: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 767767Polyribonucleotide nucleotidyltransferasePRO_1000147928Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi395495.Lcho_1497.

Structurei

3D structure databases

ProteinModelPortaliB1Y823.
SMRiB1Y823. Positions 619-692.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini555 – 61460KHUniRule annotationAdd
BLAST
Domaini624 – 69269S1 motifUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation
Contains 1 KH domain.UniRule annotation
Contains 1 S1 motif domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG1185.
HOGENOMiHOG000218326.
KOiK00962.
OMAiHGNFKSN.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B1Y823-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSLFNKVTKT FQWGQHTVTL ETGEISRQAG GAVIVNIDDT VVLATVVGAK
60 70 80 90 100
NAKPGQDFFP LTVDYIEKTY AAGKIPGSFF KREAKPSELE VLTSRLIDRP
110 120 130 140 150
LRPLFPEGFY NEVHVVVHVL SLNPEASADI AALIGSSAAL AISGIPFNGP
160 170 180 190 200
VGAARVGYVN GEYVLNPGPT QLKSSKMDLV VAGTEAAVLM VESEADQLTE
210 220 230 240 250
EVMLGAVVYG HEQAKVAIAA INELVRDAGK PAWDWQPPAR NEPLIAKVAE
260 270 280 290 300
FGLAKIEAAY QIRNKQARTH ACRAAYAEVK ISLAEAGVVF DNVDVDNLLF
310 320 330 340 350
ELEAKTVRGQ ILQGEPRIDG RDTRTVRPIE IRTGVLPRTH GSALFTRGET
360 370 380 390 400
QALVVATLGT DQDSQRIDAL AGDFRDSFLF HYNMPPFATG EVGRMGTTKR
410 420 430 440 450
RETGHGRLAK RALVPLLPPK DEFGYTIRVV SEITESNGSS SMASVCGGCL
460 470 480 490 500
AMMDAGVPMK AHVAGIAMGL IKEGNRFAVL TDILGDEDHL GDMDFKVAGT
510 520 530 540 550
TAGVTALQMD IKIQGITKEI MQVALAQAKE ARLHILGKMV EAMGTANTEV
560 570 580 590 600
SNFAPRLYTM KINPEKIRDV IGKGGSVIRA LTEETGCQID IGEDGTITIA
610 620 630 640 650
STDADKAELA KKRIADITAE AEIGKVYEGP VVKILDFGAL INILPGKDGL
660 670 680 690 700
LHISQIAHQR VEKVTDFLTE GQVVKVKVLE TDEKGRIKLS MKALIERPEG
710 720 730 740 750
MEFEERAPRR EGGFGDRGDR GDRGPRRDRG GDRPERGERP ARAEQPATEE
760
SGAPAAGQPQ QQQGQQQ
Length:767
Mass (Da):82,747
Last modified:May 20, 2008 - v1
Checksum:iC612CD85B1CEF76E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001013 Genomic DNA. Translation: ACB33765.1.
RefSeqiWP_012346527.1. NC_010524.1.
YP_001790530.1. NC_010524.1.

Genome annotation databases

EnsemblBacteriaiACB33765; ACB33765; Lcho_1497.
GeneIDi6162411.
KEGGilch:Lcho_1497.
PATRICi22393293. VBILepCho83238_1499.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001013 Genomic DNA. Translation: ACB33765.1 .
RefSeqi WP_012346527.1. NC_010524.1.
YP_001790530.1. NC_010524.1.

3D structure databases

ProteinModelPortali B1Y823.
SMRi B1Y823. Positions 619-692.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 395495.Lcho_1497.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACB33765 ; ACB33765 ; Lcho_1497 .
GeneIDi 6162411.
KEGGi lch:Lcho_1497.
PATRICi 22393293. VBILepCho83238_1499.

Phylogenomic databases

eggNOGi COG1185.
HOGENOMi HOG000218326.
KOi K00962.
OMAi HGNFKSN.
OrthoDBi EOG6WT8CC.

Enzyme and pathway databases

BioCyci LCHO395495:GHYL-1515-MONOMER.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005499. PNPase. 1 hit.
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51168 / LMG 8142 / SP-6.

Entry informationi

Entry nameiPNP_LEPCP
AccessioniPrimary (citable) accession number: B1Y823
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: May 20, 2008
Last modified: November 26, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3