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B1Y6J4 (B1Y6J4_LEPCP) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 28. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ferrochelatase HAMAP MF_00323
EC=4.99.1.1 HAMAP MF_00323
Alternative name(s):
Heme synthase HAMAP MF_00323
Protoheme ferro-lyase HAMAP MF_00323
Gene names
Name:hemH HAMAP MF_00323
Ordered Locus Names:Lcho_2565
OrganismLeptothrix cholodnii (strain ATCC 51168 / LMG 8142 / SP-6) (Leptothrix discophora (strain SP-6)) [Complete proteome] [HAMAP] EMBL ACB34830.1
Taxonomic identifier395495 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Leptothrix

Protein attributes

Sequence length368 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the ferrous insertion into protoporphyrin IX By similarity. HAMAP MF_00323

Catalytic activity

Protoheme + 2 H+ = protoporphyrin + Fe2+. HAMAP MF_00323

Pathway

Porphyrin metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1. HAMAP MF_00323

Subcellular location

Cytoplasm By similarity HAMAP MF_00323.

Sequence similarities

Belongs to the ferrochelatase family. HAMAP MF_00323

Ontologies

Keywords
   Biological processHeme biosynthesis HAMAP MF_00323
Porphyrin biosynthesis HAMAP MF_00323
   Cellular componentCytoplasm HAMAP MF_00323
   LigandIron HAMAP MF_00323
Metal-binding HAMAP MF_00323
   Molecular functionLyase HAMAP MF_00323 EMBL ACB34830.1
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processheme biosynthetic process

Inferred from electronic annotation. Source: HAMAP

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionferrochelatase activity

Inferred from electronic annotation. Source: HAMAP

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Metal binding2121Iron By similarity HAMAP MF_00323
Metal binding2931Iron By similarity HAMAP MF_00323

Sequences

Sequence LengthMass (Da)Tools
B1Y6J4 [UniParc].

Last modified May 20, 2008. Version 1.
Checksum: 97C9B106BAB03A13

FASTA36841,327
        10         20         30         40         50         60 
MPTPRYAPEP PYRHGSAPRI GVLLVNLGTP DAPRTAEVRR YLAEFLSDPR VVEIPRAIWL 

        70         80         90        100        110        120 
AILHGIILRV RPAKSAAKYA SVWTAEGSPL AVWTRRQATM LQGYLGERGL QVTVAHAMRY 

       130        140        150        160        170        180 
GQPAVAATLD QLKQAGCDRI LVLPMYPQYS GTTTASVWDA VAAWSLKQRN LPELRFVKQH 

       190        200        210        220        230        240 
HDEPSYIDAL ARRVEDFWAR EGRGDHLLLS FHGVPERTLH LGDPYHCQCL KTGRLLRERL 

       250        260        270        280        290        300 
GLSEQNLSVS FQSRFGKAKW LEPYTEATLK GLAKRGVKHL QVFCPGFPAD CLETLEEIAI 

       310        320        330        340        350        360 
EGRELFLHAG GQRFEHIPCL NDHPAWIQSL VAIVQRHTGG WPVMRDEQPR AAELESQRLR 


ALALGAKT

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References

[1]"Complete sequence of Leptothrix cholodnii SP-6."
Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Chertkov O., Brettin T., Detter J.C., Han C., Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L. expand/collapse author list , Kyrpides N., Lykidis A., Emerson D., Richardson P.
Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 51168 / LMG 8142 / SP-6.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001013 Genomic DNA. Translation: ACB34830.1.
RefSeqYP_001791595.1. NC_010524.1.

3D structure databases

ProteinModelPortalB1Y6J4.
ModBaseSearch...

Protein-protein interaction databases

STRINGB1Y6J4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6162984.
GenomeReviewsGene locus Lcho_2565 in contig CP001013_GR.
KEGGlch:Lcho_2565.
PATRIC22395517. VBILepCho83238_2587.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG697135.
OMAIRPAKSA.

Family and domain databases

HAMAPMF_00323. Ferrochelatase.
[Tree]
InterProIPR001015. Ferrochelatase.
IPR019772. Ferrochelatase_AS.
[Graphical view]
KOK01772.
PANTHERPTHR11108. Ferrochelatase. 1 hit.
PfamPF00762. Ferrochelatase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00109. HemH. 1 hit.
PROSITEPS00534. FERROCHELATASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameB1Y6J4_LEPCP
AccessionPrimary (citable) accession number: B1Y6J4
Entry history
Integrated into UniProtKB/TrEMBL: May 20, 2008
Last sequence update: May 20, 2008
Last modified: December 14, 2011
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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