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Reviewed, UniProtKB/Swiss-Prot B1Y5W3 (F16A2_LEPCP)

Last modified January 19, 2010. Version 16. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Fructose-1,6-bisphosphatase class 1 2
      Short name=FBPase class 1 2
    EC=3.1.3.11
Alternative name(s):
    D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 2
Gene names
Name: fbp2
Ordered Locus Names: Lcho_3755
OrganismLeptothrix cholodnii (strain ATCC 51168 / LMG 8142 / SP-6) (Leptothrix discophora (strain SP-6)) [Complete proteome] [HAMAP]
Taxonomic identifier395495 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Leptothrix

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Protein attributes

Sequence length365 AA.
Sequence statusComplete.
Protein existenceInferred from homology.

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General annotation (Comments)

Catalytic activity

D-fructose 1,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate. HAMAP MF_01855

Cofactor

Binds 2 magnesium ions per subunit By similarity. HAMAP MF_01855

Pathway

Carbohydrate biosynthesis; gluconeogenesis. HAMAP MF_01855

Subunit structure

Homotetramer By similarity. HAMAP MF_01855

Subcellular location

Cytoplasm Potential HAMAP MF_01855.

Sequence similarities

Belongs to the FBPase class 1 family.

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Ontologies

Keywords
   Biological processCarbohydrate metabolism
   Cellular componentCytoplasm
   LigandMagnesium
Metal-binding
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processcarbohydrate biosynthetic process

Inferred from electronic annotation. Source: HAMAP

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionfructose 1,6-bisphosphate 1-phosphatase activity

Inferred from electronic annotation. Source: HAMAP

magnesium ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 365365Fructose-1,6-bisphosphatase class 1 2 HAMAP MF_01855
PRO_0000364591

Regions

Region125 – 1284Substrate binding By similarity

Sites

Metal binding1001Magnesium 1 By similarity
Metal binding1221Magnesium 1 By similarity
Metal binding1221Magnesium 2 By similarity
Metal binding1241Magnesium 1; via carbonyl oxygen By similarity
Metal binding1251Magnesium 2 By similarity
Metal binding2931Magnesium 2 By similarity
Binding site2211Substrate By similarity

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Sequences

Sequence LengthMass (Da)Tools
B1Y5W3-1 [UniParc].

Last modified May 20, 2008. Version 1.
Checksum: 072685E164DEBEFF

FASTA36539,829
        10         20         30         40         50         60 
MPLSNRSTLT QYLIEERRRF PGASGELNAL ILDVSLACKA IARAVAFGEL GDALGDAAAM 

        70         80         90        100        110        120 
PTGGAVNVQG EVQKKLDVLS NEVFIRRNEW SGSLAGMASE EMETPYQIPG QYPRGKYLLV 

       130        140        150        160        170        180 
FDPLDGSSNI DVNVSVGSIF SILRAPQDVI DSGRDVTEAD FLQPGAAQVA AGYALYGPTT 

       190        200        210        220        230        240 
MLMLTVGNGV AGFTLNPTLG EFMLTHANVT VPADTREFAI NASNARFWEP PVKRYVDECL 

       250        260        270        280        290        300 
AGATGPRGKD FNMRWIASMV AEAHRILMRG GVFMYPRDTK DASKPGRLRL LYEANPIGML 

       310        320        330        340        350        360 
MEQAGGRAST GRQPMLGVKP TSLHQRIGLV FGSKNEVERI ERYHHEPVTR EFATPLFAER 


SLFRD

« Hide

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References

[1]"Complete sequence of Leptothrix cholodnii SP-6."
Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Chertkov O., Brettin T., Detter J.C., Han C., Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L. expand/collapse author list , Kyrpides N., Lykidis A., Emerson D., Richardson P.
Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001013 Genomic DNA. Translation: ACB36009.1.
RefSeqYP_001792774.1.

3D structure databases

SMRB1Y5W3. Positions 7-344.
ModBaseSearch...

Genome annotation databases

GeneID6164025.
GenomeReviewsGene locus Lcho_3755 in contig CP001013_GR.
KEGGlch:Lcho_3755.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG731261.
OMADGDGQKA.

Family and domain databases

HAMAPMF_01855. FBPase_class1.
[Tree]
InterProIPR000146. Fructose_bisphosphatase.
IPR020548. Fructose_bisphosphatase_AS.
[Graphical view]
PANTHERPTHR11556. In_FB_phphtase. 1 hit.
PfamPF00316. FBPase. 1 hit.
[Graphical view]
PRINTSPR00115. F16BPHPHTASE.
PROSITEPS00124. FBPASE. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameF16A2_LEPCP
AccessionPrimary (citable) accession number: B1Y5W3
Entry history
Integrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: May 20, 2008
Last modified: January 19, 2010
This is version 16 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents