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B1Y3E4

- THIM_LEPCP

UniProt

B1Y3E4 - THIM_LEPCP

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Protein

Hydroxyethylthiazole kinase

Gene
thiM, Lcho_2206
Organism
Leptothrix cholodnii (strain ATCC 51168 / LMG 8142 / SP-6) (Leptothrix discophora (strain SP-6))
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei51 – 511Substrate; via amide nitrogen By similarity
Binding sitei127 – 1271ATP By similarity
Binding sitei173 – 1731ATP By similarity
Binding sitei201 – 2011Substrate; via amide nitrogen By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. hydroxyethylthiazole kinase activity Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. thiamine biosynthetic process Source: UniProtKB-KW
  2. thiamine diphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Thiamine biosynthesis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciLCHO395495:GHYL-2241-MONOMER.
UniPathwayiUPA00060; UER00139.

Names & Taxonomyi

Protein namesi
Recommended name:
Hydroxyethylthiazole kinase (EC:2.7.1.50)
Alternative name(s):
4-methyl-5-beta-hydroxyethylthiazole kinase
Short name:
TH kinase
Short name:
Thz kinase
Gene namesi
Name:thiM
Ordered Locus Names:Lcho_2206
OrganismiLeptothrix cholodnii (strain ATCC 51168 / LMG 8142 / SP-6) (Leptothrix discophora (strain SP-6))
Taxonomic identifieri395495 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesLeptothrix
ProteomesiUP000001693: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 278278Hydroxyethylthiazole kinaseUniRule annotationPRO_0000383879Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi395495.Lcho_2206.

Structurei

3D structure databases

ProteinModelPortaliB1Y3E4.

Family & Domainsi

Sequence similaritiesi

Belongs to the Thz kinase family.

Phylogenomic databases

eggNOGiCOG2145.
HOGENOMiHOG000114352.
KOiK00878.
OrthoDBiEOG628F8M.

Family and domain databases

Gene3Di3.40.1190.20. 1 hit.
HAMAPiMF_00228. Thz_kinase.
InterProiIPR000417. Hyethyz_kinase.
IPR029056. Ribokinase-like.
[Graphical view]
PfamiPF02110. HK. 1 hit.
[Graphical view]
PIRSFiPIRSF000513. Thz_kinase. 1 hit.
PRINTSiPR01099. HYETHTZKNASE.
SUPFAMiSSF53613. SSF53613. 1 hit.
TIGRFAMsiTIGR00694. thiM. 1 hit.

Sequencei

Sequence statusi: Complete.

B1Y3E4-1 [UniParc]FASTAAdd to Basket

« Hide

MSLAAPLTAA DLWADVLAVR AQSPLVHSIT NFVVMNFNAN VLLALGAAPV    50
MAHAHDEVAD MAGIAQALVL NIGTLEPAWV ESMHKARRAA RARGIPVVLD 100
PVGAGATAYR NRALSGLLAA GAPTVIRGNG SEVLSVAGLG APTRGVDSTL 150
SSNDAVAAAQ TLSRRIGSVV CVSGADDHVV DALGRWATLS NGHPWMTRIT 200
GVGCSATAMI GAFAAVQPDA WRATTAAMAY LGVVGEWAAE QVIAAGNGVG 250
SLQVKLLDGL QLLDDATFRA RLKMTVHG 278
Length:278
Mass (Da):28,439
Last modified:September 22, 2009 - v2
Checksum:iE5462D3D455E51D1
GO

Sequence cautioni

The sequence ACB34472.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001013 Genomic DNA. Translation: ACB34472.1. Different initiation.
RefSeqiYP_001791237.1. NC_010524.1.

Genome annotation databases

EnsemblBacteriaiACB34472; ACB34472; Lcho_2206.
GeneIDi6163308.
KEGGilch:Lcho_2206.
PATRICi22394789. VBILepCho83238_2230.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001013 Genomic DNA. Translation: ACB34472.1 . Different initiation.
RefSeqi YP_001791237.1. NC_010524.1.

3D structure databases

ProteinModelPortali B1Y3E4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 395495.Lcho_2206.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACB34472 ; ACB34472 ; Lcho_2206 .
GeneIDi 6163308.
KEGGi lch:Lcho_2206.
PATRICi 22394789. VBILepCho83238_2230.

Phylogenomic databases

eggNOGi COG2145.
HOGENOMi HOG000114352.
KOi K00878.
OrthoDBi EOG628F8M.

Enzyme and pathway databases

UniPathwayi UPA00060 ; UER00139 .
BioCyci LCHO395495:GHYL-2241-MONOMER.

Family and domain databases

Gene3Di 3.40.1190.20. 1 hit.
HAMAPi MF_00228. Thz_kinase.
InterProi IPR000417. Hyethyz_kinase.
IPR029056. Ribokinase-like.
[Graphical view ]
Pfami PF02110. HK. 1 hit.
[Graphical view ]
PIRSFi PIRSF000513. Thz_kinase. 1 hit.
PRINTSi PR01099. HYETHTZKNASE.
SUPFAMi SSF53613. SSF53613. 1 hit.
TIGRFAMsi TIGR00694. thiM. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51168 / LMG 8142 / SP-6.

Entry informationi

Entry nameiTHIM_LEPCP
AccessioniPrimary (citable) accession number: B1Y3E4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: September 22, 2009
Last modified: June 11, 2014
This is version 43 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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