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Protein

Glutamate--tRNA ligase

Gene

gltX

Organism
Leptothrix cholodnii (strain ATCC 51168 / LMG 8142 / SP-6) (Leptothrix discophora (strain SP-6))
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei249ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciLCHO395495:G1GBL-1700-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligaseUniRule annotation (EC:6.1.1.17UniRule annotation)
Alternative name(s):
Glutamyl-tRNA synthetaseUniRule annotation
Short name:
GluRSUniRule annotation
Gene namesi
Name:gltXUniRule annotation
Ordered Locus Names:Lcho_1690
OrganismiLeptothrix cholodnii (strain ATCC 51168 / LMG 8142 / SP-6) (Leptothrix discophora (strain SP-6))
Taxonomic identifieri395495 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesLeptothrix
Proteomesi
  • UP000001693 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003677011 – 468Glutamate--tRNA ligaseAdd BLAST468

Proteomic databases

PRIDEiB1XY56

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi395495.Lcho_1690

Structurei

3D structure databases

ProteinModelPortaliB1XY56
SMRiB1XY56
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi14 – 24"HIGH" regionUniRule annotationAdd BLAST11
Motifi246 – 250"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C20 Bacteria
COG0008 LUCA
HOGENOMiHOG000252722
KOiK01885
OMAiAYYAFDT
OrthoDBiPOG091H021W

Family and domain databases

CDDicd00808 GluRS_core, 1 hit
Gene3Di1.10.10.350, 1 hit
3.40.50.620, 1 hit
HAMAPiMF_00022 Glu_tRNA_synth_type1, 1 hit
InterProiView protein in InterPro
IPR008925 aa-tRNA-synth_I_codon-bd
IPR020751 aa-tRNA-synth_I_codon-bd_sub2
IPR001412 aa-tRNA-synth_I_CS
IPR004527 Glu-tRNA-ligase_bac/mito
IPR000924 Glu/Gln-tRNA-synth
IPR020058 Glu/Gln-tRNA-synth_Ib_cat-dom
IPR033910 GluRS_core
IPR014729 Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF00749 tRNA-synt_1c, 1 hit
PRINTSiPR00987 TRNASYNTHGLU
SUPFAMiSSF48163 SSF48163, 1 hit
TIGRFAMsiTIGR00464 gltX_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

B1XY56-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTQVSTPVRT RFAPSPTGFI HLGNIRSALY PWAFARATGG TFVLRIEDTD
60 70 80 90 100
VERSSQAAVD VIVEGMKWLG LDHDEGPFFQ MQRMARYKEV LAQLVARGQV
110 120 130 140 150
YPCYMSMTEL DALRERQMAN KEKPRYDGTW RPEPGKVLPA VPEGVQPVLR
160 170 180 190 200
FRTPQGGSVI WDDKVKGRIE ISNDELDDLV IARPDGTPTY NFCVVVDDID
210 220 230 240 250
MAITHVIRGD DHVNNTPRQI HIFRALGQEP PVYAHLPTVL NEQGEKMSKR
260 270 280 290 300
HGAKPVTQYR EEGFLADAVV NYLARLGWSH GDDEIFSRAQ LIEWFNLDHL
310 320 330 340 350
GKSAGQYDEA KLRWVNSQHM KLCDNGVLAG LVAEQFARRE LLVPVDERLA
360 370 380 390 400
RMCALFKDRC STTVELADWL SMYFVPIQAS EQDLAAHVTD AVRPALQTLR
410 420 430 440 450
DKLAALASWD KASISLCIKE TIATHALKMP LLAVPVRVLV TGRAQTPSVD
460
AVLELFQQEI VLKRLQSV
Length:468
Mass (Da):52,622
Last modified:May 20, 2008 - v1
Checksum:iD27466157F32878E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001013 Genomic DNA Translation: ACB33957.1
RefSeqiWP_012346718.1, NC_010524.1

Genome annotation databases

EnsemblBacteriaiACB33957; ACB33957; Lcho_1690
KEGGilch:Lcho_1690

Similar proteinsi

Entry informationi

Entry nameiSYE_LEPCP
AccessioniPrimary (citable) accession number: B1XY56
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: May 20, 2008
Last modified: May 23, 2018
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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