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B1XXY5

- SYL_LEPCP

UniProt

B1XXY5 - SYL_LEPCP

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Leptothrix cholodnii (strain ATCC 51168 / LMG 8142 / SP-6) (Leptothrix discophora (strain SP-6))
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 1 (20 May 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei647 – 6471ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciLCHO395495:GHYL-484-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:Lcho_0479
    OrganismiLeptothrix cholodnii (strain ATCC 51168 / LMG 8142 / SP-6) (Leptothrix discophora (strain SP-6))
    Taxonomic identifieri395495 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesLeptothrix
    ProteomesiUP000001693: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 887887Leucine--tRNA ligasePRO_1000091333Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi395495.Lcho_0479.

    Structurei

    3D structure databases

    ProteinModelPortaliB1XXY5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi48 – 5811"HIGH" regionAdd
    BLAST
    Motifi644 – 6485"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiPVIHCPK.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B1XXY5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNEKYDPAAI ESAAHAQWVA ADAYRVDENA RDSQGQLKPK FYACSMLPYP    50
    SGKLHMGHVR NYTINDMLTR QLRMKGMNVL MPMGWDAFGL PAENAALKNS 100
    VPPEKWTREN IATMKGQMLA MGLAIDWSRE VATCDPTYYK WNQWLFLKML 150
    EAGIAERRTQ VVNWDPVDQT VLANEQVIDG RGWRSGALVE KREIPGYYLN 200
    IVKYADELLG AVANPEDPNY LSGWPERVRL MQENWIGKSE GVRFAFPHQI 250
    AGADGELIQG GKLYVFTTRA DTIMGVTFCA VAPEHPLAAH AAATNPALAA 300
    FIAECAHGGT TEAELATQEK KGLPTGLFVT HPLTGAQVEV WVGNYVLMSY 350
    GDGAVMGVPA HDERDFAFAK KYGISIRQVV QAEGQTFSLD GWADWYGDKQ 400
    RAVCVNSGLL DGLPYKEAVS KVAELVGAQG LGEKKTTWRL RDWGISRQRY 450
    WGTPIPIIHC DDCGSVPVPE KDLPVVLPID CVPDGSGNPL KKRTDFLNVA 500
    CPCCGKPAQR ETDTMDTFVD SSWYFMRYCD ARNSEQMVAG GTDYWMPMDQ 550
    YIGGIEHAIL HLLYARFWTK VMRDLGLVKV NEPFTKLLTQ GMVLNHIYSR 600
    RTDKGGIEYF WPHEVENVFD AGGKVTGAKL KSDGSAVDYG GIGTMSKSKN 650
    NGVDPQDLIN QYGADTARLF VMFASPPEQT LEWNDAGVEG AHRFLKRVWG 700
    FGVKQAELLK GATEVGAELS GDAKALRREV HLVLRQVSYD YERMQYNTVV 750
    SGSMKLLNAL EAYKHDGSAG SAAVLREGYS VLLRGLYPAC PHITHHLWSE 800
    LGYAAKLGDL LDAPWPEVVE AALVQDEIEL VLQVNGKTRG SIKVPAAADK 850
    AAIEAAAAAS AEVAKFADGK PIRKLIVVPG RLVNVVV 887
    Length:887
    Mass (Da):97,733
    Last modified:May 20, 2008 - v1
    Checksum:i36C42A1C68EF7FDD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001013 Genomic DNA. Translation: ACB32754.1.
    RefSeqiYP_001789519.1. NC_010524.1.

    Genome annotation databases

    EnsemblBacteriaiACB32754; ACB32754; Lcho_0479.
    GeneIDi6162097.
    KEGGilch:Lcho_0479.
    PATRICi22391243. VBILepCho83238_0486.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001013 Genomic DNA. Translation: ACB32754.1 .
    RefSeqi YP_001789519.1. NC_010524.1.

    3D structure databases

    ProteinModelPortali B1XXY5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 395495.Lcho_0479.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACB32754 ; ACB32754 ; Lcho_0479 .
    GeneIDi 6162097.
    KEGGi lch:Lcho_0479.
    PATRICi 22391243. VBILepCho83238_0486.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi PVIHCPK.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci LCHO395495:GHYL-484-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 51168 / LMG 8142 / SP-6.

    Entry informationi

    Entry nameiSYL_LEPCP
    AccessioniPrimary (citable) accession number: B1XXY5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: May 20, 2008
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3