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B1XXY5

- SYL_LEPCP

UniProt

B1XXY5 - SYL_LEPCP

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Leptothrix cholodnii (strain ATCC 51168 / LMG 8142 / SP-6) (Leptothrix discophora (strain SP-6))
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei647 – 6471ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciLCHO395495:GHYL-484-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Lcho_0479
OrganismiLeptothrix cholodnii (strain ATCC 51168 / LMG 8142 / SP-6) (Leptothrix discophora (strain SP-6))
Taxonomic identifieri395495 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesLeptothrix
ProteomesiUP000001693: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 887887Leucine--tRNA ligasePRO_1000091333Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi395495.Lcho_0479.

Structurei

3D structure databases

ProteinModelPortaliB1XXY5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi48 – 5811"HIGH" regionAdd
BLAST
Motifi644 – 6485"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiPVIHCPK.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B1XXY5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNEKYDPAAI ESAAHAQWVA ADAYRVDENA RDSQGQLKPK FYACSMLPYP
60 70 80 90 100
SGKLHMGHVR NYTINDMLTR QLRMKGMNVL MPMGWDAFGL PAENAALKNS
110 120 130 140 150
VPPEKWTREN IATMKGQMLA MGLAIDWSRE VATCDPTYYK WNQWLFLKML
160 170 180 190 200
EAGIAERRTQ VVNWDPVDQT VLANEQVIDG RGWRSGALVE KREIPGYYLN
210 220 230 240 250
IVKYADELLG AVANPEDPNY LSGWPERVRL MQENWIGKSE GVRFAFPHQI
260 270 280 290 300
AGADGELIQG GKLYVFTTRA DTIMGVTFCA VAPEHPLAAH AAATNPALAA
310 320 330 340 350
FIAECAHGGT TEAELATQEK KGLPTGLFVT HPLTGAQVEV WVGNYVLMSY
360 370 380 390 400
GDGAVMGVPA HDERDFAFAK KYGISIRQVV QAEGQTFSLD GWADWYGDKQ
410 420 430 440 450
RAVCVNSGLL DGLPYKEAVS KVAELVGAQG LGEKKTTWRL RDWGISRQRY
460 470 480 490 500
WGTPIPIIHC DDCGSVPVPE KDLPVVLPID CVPDGSGNPL KKRTDFLNVA
510 520 530 540 550
CPCCGKPAQR ETDTMDTFVD SSWYFMRYCD ARNSEQMVAG GTDYWMPMDQ
560 570 580 590 600
YIGGIEHAIL HLLYARFWTK VMRDLGLVKV NEPFTKLLTQ GMVLNHIYSR
610 620 630 640 650
RTDKGGIEYF WPHEVENVFD AGGKVTGAKL KSDGSAVDYG GIGTMSKSKN
660 670 680 690 700
NGVDPQDLIN QYGADTARLF VMFASPPEQT LEWNDAGVEG AHRFLKRVWG
710 720 730 740 750
FGVKQAELLK GATEVGAELS GDAKALRREV HLVLRQVSYD YERMQYNTVV
760 770 780 790 800
SGSMKLLNAL EAYKHDGSAG SAAVLREGYS VLLRGLYPAC PHITHHLWSE
810 820 830 840 850
LGYAAKLGDL LDAPWPEVVE AALVQDEIEL VLQVNGKTRG SIKVPAAADK
860 870 880
AAIEAAAAAS AEVAKFADGK PIRKLIVVPG RLVNVVV
Length:887
Mass (Da):97,733
Last modified:May 20, 2008 - v1
Checksum:i36C42A1C68EF7FDD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001013 Genomic DNA. Translation: ACB32754.1.
RefSeqiWP_012345516.1. NC_010524.1.
YP_001789519.1. NC_010524.1.

Genome annotation databases

EnsemblBacteriaiACB32754; ACB32754; Lcho_0479.
GeneIDi6162097.
KEGGilch:Lcho_0479.
PATRICi22391243. VBILepCho83238_0486.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001013 Genomic DNA. Translation: ACB32754.1 .
RefSeqi WP_012345516.1. NC_010524.1.
YP_001789519.1. NC_010524.1.

3D structure databases

ProteinModelPortali B1XXY5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 395495.Lcho_0479.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACB32754 ; ACB32754 ; Lcho_0479 .
GeneIDi 6162097.
KEGGi lch:Lcho_0479.
PATRICi 22391243. VBILepCho83238_0486.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi PVIHCPK.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci LCHO395495:GHYL-484-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51168 / LMG 8142 / SP-6.

Entry informationi

Entry nameiSYL_LEPCP
AccessioniPrimary (citable) accession number: B1XXY5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: May 20, 2008
Last modified: October 29, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3