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B1XXL7

- NDK_LEPCP

UniProt

B1XXL7 - NDK_LEPCP

Protein

Nucleoside diphosphate kinase

Gene

ndk

Organism
Leptothrix cholodnii (strain ATCC 51168 / LMG 8142 / SP-6) (Leptothrix discophora (strain SP-6))
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 40 (01 Oct 2014)
      Sequence version 1 (20 May 2008)
      Previous versions | rss
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    Functioni

    Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.UniRule annotation

    Catalytic activityi

    ATP + nucleoside diphosphate = ADP + nucleoside triphosphate.UniRule annotation

    Cofactori

    Magnesium.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei11 – 111ATPUniRule annotation
    Binding sitei59 – 591ATPUniRule annotation
    Binding sitei87 – 871ATPUniRule annotation
    Binding sitei93 – 931ATPUniRule annotation
    Binding sitei104 – 1041ATPUniRule annotation
    Binding sitei114 – 1141ATPUniRule annotation
    Active sitei117 – 1171Pros-phosphohistidine intermediateUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. metal ion binding Source: UniProtKB-KW
    3. nucleoside diphosphate kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. CTP biosynthetic process Source: UniProtKB-HAMAP
    2. GTP biosynthetic process Source: UniProtKB-HAMAP
    3. UTP biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Nucleotide metabolism

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciLCHO395495:GHYL-2919-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nucleoside diphosphate kinaseUniRule annotation (EC:2.7.4.6UniRule annotation)
    Short name:
    NDKUniRule annotation
    Short name:
    NDP kinaseUniRule annotation
    Alternative name(s):
    Nucleoside-2-P kinaseUniRule annotation
    Gene namesi
    Name:ndkUniRule annotation
    Ordered Locus Names:Lcho_2872
    OrganismiLeptothrix cholodnii (strain ATCC 51168 / LMG 8142 / SP-6) (Leptothrix discophora (strain SP-6))
    Taxonomic identifieri395495 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesLeptothrix
    ProteomesiUP000001693: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 141141Nucleoside diphosphate kinasePRO_1000192268Add
    BLAST

    Keywords - PTMi

    Phosphoprotein

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Protein-protein interaction databases

    STRINGi395495.Lcho_2872.

    Structurei

    3D structure databases

    ProteinModelPortaliB1XXL7.
    SMRiB1XXL7. Positions 2-140.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NDK family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0105.
    HOGENOMiHOG000224565.
    KOiK00940.
    OMAiKRIHMTR.
    OrthoDBiEOG67DPRV.

    Family and domain databases

    Gene3Di3.30.70.141. 1 hit.
    HAMAPiMF_00451. NDP_kinase.
    InterProiIPR001564. Nucleoside_diP_kinase.
    IPR023005. Nucleoside_diP_kinase_AS.
    [Graphical view]
    PfamiPF00334. NDK. 1 hit.
    [Graphical view]
    PRINTSiPR01243. NUCDPKINASE.
    SMARTiSM00562. NDK. 1 hit.
    [Graphical view]
    SUPFAMiSSF54919. SSF54919. 1 hit.
    PROSITEiPS00469. NDP_KINASES. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B1XXL7-1 [UniParc]FASTAAdd to Basket

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    MAIERTLSII KPDAVAKNVI GQILARFEGA GLKIAAARLA QLSRAEAEQF    50
    YAVHKARPFF NDLVNFMISG PVMIQVLEGE GAILKNRDLM GATDPKKAEK 100
    GTIRADFADS IDANAVHGSD APETAAVEIA FFFPGMAVYS R 141
    Length:141
    Mass (Da):15,166
    Last modified:May 20, 2008 - v1
    Checksum:iE353CB75AC00869B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001013 Genomic DNA. Translation: ACB35137.1.
    RefSeqiWP_012347891.1. NC_010524.1.
    YP_001791902.1. NC_010524.1.

    Genome annotation databases

    EnsemblBacteriaiACB35137; ACB35137; Lcho_2872.
    GeneIDi6159747.
    KEGGilch:Lcho_2872.
    PATRICi22396155. VBILepCho83238_2903.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001013 Genomic DNA. Translation: ACB35137.1 .
    RefSeqi WP_012347891.1. NC_010524.1.
    YP_001791902.1. NC_010524.1.

    3D structure databases

    ProteinModelPortali B1XXL7.
    SMRi B1XXL7. Positions 2-140.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 395495.Lcho_2872.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACB35137 ; ACB35137 ; Lcho_2872 .
    GeneIDi 6159747.
    KEGGi lch:Lcho_2872.
    PATRICi 22396155. VBILepCho83238_2903.

    Phylogenomic databases

    eggNOGi COG0105.
    HOGENOMi HOG000224565.
    KOi K00940.
    OMAi KRIHMTR.
    OrthoDBi EOG67DPRV.

    Enzyme and pathway databases

    BioCyci LCHO395495:GHYL-2919-MONOMER.

    Family and domain databases

    Gene3Di 3.30.70.141. 1 hit.
    HAMAPi MF_00451. NDP_kinase.
    InterProi IPR001564. Nucleoside_diP_kinase.
    IPR023005. Nucleoside_diP_kinase_AS.
    [Graphical view ]
    Pfami PF00334. NDK. 1 hit.
    [Graphical view ]
    PRINTSi PR01243. NUCDPKINASE.
    SMARTi SM00562. NDK. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54919. SSF54919. 1 hit.
    PROSITEi PS00469. NDP_KINASES. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 51168 / LMG 8142 / SP-6.

    Entry informationi

    Entry nameiNDK_LEPCP
    AccessioniPrimary (citable) accession number: B1XXL7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: May 20, 2008
    Last modified: October 1, 2014
    This is version 40 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3