B1XXG0 (GLMM_LEPCP) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphoglucosamine mutase
EC=5.4.2.10

Gene names

Name:	glmM
Ordered Locus Names:	Lcho_2815

Organism

Leptothrix cholodnii (strain ATCC 51168 / LMG 8142 / SP-6) (Leptothrix discophora (strain SP-6)) [Complete proteome] [HAMAP]

Taxonomic identifier

395495 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Leptothrix

Protein attributes

Sequence length	444 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate By similarity. HAMAP MF_01554_B
Catalytic activity	Alpha-D-glucosamine 1-phosphate = D-glucosamine 6-phosphate. HAMAP MF_01554_B
Cofactor	Binds 1 magnesium ion per subunit By similarity. HAMAP MF_01554_B
Post-translational modification	Activated by phosphorylation By similarity. HAMAP MF_01554_B
Sequence similarities	Belongs to the phosphohexose mutase family.

Ontologies

Keywords
Ligand	Magnesium Metal-binding
Molecular function	Isomerase
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	carbohydrate metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	magnesium ion binding Inferred from electronic annotation. Source: InterPro phosphoglucosamine mutase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 444	444	Phosphoglucosamine mutase HAMAP MF_01554_B		PRO_1000201115
Sites
	Active site	102	1	Phosphoserine intermediate By similarity
	Metal binding	102	1	Magnesium; via phosphate group By similarity
	Metal binding	241	1	Magnesium By similarity
	Metal binding	243	1	Magnesium By similarity
	Metal binding	245	1	Magnesium By similarity
Amino acid modifications
	Modified residue	102	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	B1XXG0 [UniParc]. Last modified May 20, 2008. Version 1. Checksum: 46A371CB69EB2756	FASTA	444	47,655
	10 20 30 40 50 60 MSRKYFGTDG IRGEVGTSPI TPDFVLRLGH AVGRVLRGTH DRPVVLIGKD TRISGYMLES 70 80 90 100 110 120 ALEAGLNSAG VDVMLTGPLP TPAVAYLTRA LRLSLGVVIS ASHNHFMDNG IKFFSARGEK 130 140 150 160 170 180 LSDAWEMEVE AAIEAPPQWS DSSQIGRARR LHDAPGRYVE FCKSTFSNEL SLKGLKIVVD 190 200 210 220 230 240 AANGAAYHVA PDVFHELGAD VVRIGCEPDG LNINDGVGAT SPQALVEAVR MNGADYGVAL 250 260 270 280 290 300 DGDADRVLLV DRNGRLYNGD ELLYVMVADR LAQGEPVPGA VGTLMTNMAV EVALQQRGVE 310 320 330 340 350 360 FVRAKVGDRY VLEELVSRGW QLGGEGSGHL LALDKHTTGD GIVSALQVLQ AQQRNGRSIA 370 380 390 400 410 420 ELLDGVELFP QTLINVRLAA GQDWKLNDRL ARERIAIGNE LGQSGRVLIR PSGTEPLLRV 430 440 MVEARDAAQA RLCADRLAVA AQEG

References

[1]

"Complete sequence of Leptothrix cholodnii SP-6." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Chertkov O., Brettin T., Detter J.C., Han C., Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L. , Kyrpides N., Lykidis A., Emerson D., Richardson P. Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 51168 / LMG 8142 / SP-6.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001013 Genomic DNA. Translation: ACB35080.1.
RefSeq	YP_001791845.1. NC_010524.1.
3D structure databases
ProteinModelPortal	B1XXG0.
ModBase	Search...
Protein-protein interaction databases
STRING	B1XXG0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6161656.
GenomeReviews	Gene locus Lcho_2815 in contig CP001013_GR.
KEGG	lch:Lcho_2815.
PATRIC	22396037. VBILepCho83238_2845.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG644964.
OMA	ESTDNIM.
ProtClustDB	PRK10887.
Enzyme and pathway databases
BioCyc	LCHO395495:LCHO_2815-MONOMER.
Family and domain databases
HAMAP	MF_01554_B. GlmM_B. [Tree]
InterPro	IPR005844. A-D-PHexomutase_a/b/a-I. IPR016055. A-D-PHexomutase_a/b/a-I/II/III. IPR005845. A-D-PHexomutase_a/b/a-II. IPR005846. A-D-PHexomutase_a/b/a-III. IPR005843. A-D-PHexomutase_C. IPR005841. Alpha-D-phosphohexomutase_SF. IPR006352. GlmM. [Graphical view]
Gene3D	G3DSA:3.40.120.10. A-D-PHexomutase_a/b/a-I/II/III. 3 hits.
KO	K03431.
Pfam	PF02878. PGM_PMM_I. 1 hit. PF02879. PGM_PMM_II. 1 hit. PF02880. PGM_PMM_III. 1 hit. PF00408. PGM_PMM_IV. 1 hit. [Graphical view]
PRINTS	PR00509. PGMPMM.
SUPFAM	SSF53738. A-D-PHexomutase_a/b/a-I/II/III. 3 hits.
TIGRFAMs	TIGR01455. GlmM. 1 hit.
PROSITE	PS00710. PGM_PMM. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GLMM_LEPCP

Accession

Primary (citable) accession number: B1XXG0

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	May 20, 2008
Last modified:	January 25, 2012
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program