B1XVQ5 (B1XVQ5_POLNS) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Histidinol-phosphate aminotransferase HAMAP MF_01023
EC=2.6.1.9 HAMAP MF_01023

Alternative name(s):
Imidazole acetol-phosphate transaminase HAMAP MF_01023

Gene names

Name:	hisC HAMAP MF_01023
Ordered Locus Names:	Pnec_1312

Organism

Polynucleobacter necessarius (strain STIR1) [Complete proteome] [HAMAP]

Taxonomic identifier

452638 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Polynucleobacter

Protein attributes

Sequence length	374 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate. HAMAP MF_01023 SAAS SAAS005861
Cofactor	Pyridoxal phosphate By similarity. HAMAP MF_01023 SAAS SAAS005861
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9. HAMAP MF_01023 SAAS SAAS005861
Subunit structure	Homodimer By similarity. HAMAP MF_01023
Sequence similarities	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. HAMAP MF_01023

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis HAMAP MF_01023 SAAS SAAS005861
Ligand	Pyridoxal phosphate HAMAP MF_01023 SAAS SAAS005861
Molecular function	Aminotransferase HAMAP MF_01023 SAAS SAAS005861 EMBL ACB44432.1 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	histidine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	L-phenylalanine:2-oxoglutarate aminotransferase activity Inferred from electronic annotation. Source: EC histidinol-phosphate transaminase activity Inferred from electronic annotation. Source: HAMAP pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Amino acid modifications
	Modified residue	231	1	N6-(pyridoxal phosphate)lysine By similarity HAMAP MF_01023

Sequences

	Sequence		Length	Mass (Da)
	B1XVQ5 [UniParc]. Last modified May 20, 2008. Version 1. Checksum: 697D52D2A382A053	FASTA	374	40,215
	10 20 30 40 50 60 MTSKIGLKHI HEIAPYVGGR PIGEVAREYG LDESKIVKLA SNENPLGMPK SAQDAMLKAA 70 80 90 100 110 120 SDLGRYPDSN GFELKNVLAT RLGVPTDWIT LGNGSNDILE LAARAVAQAG DEVIFSKHAF 130 140 150 160 170 180 AVYPLATQAV GAKAVEVAAT EIYGHDLPAM LAAIKSSGDK AKLVFVANPN NPTGSYLTAK 190 200 210 220 230 240 EIEDFLVGVP SNVVVVLDEA YNEYLTSEQR YDAIAWVKRF PNMILSRSFS KAYGLAGLRI 250 260 270 280 290 300 GYGVAQPHLT DLLNRIRQPF NVNSLAQAAA IAAFQDQVFL QQGFELNRAG YAQLTSAFDG 310 320 330 340 350 360 LGLKYLPSAG NFVLVKVGDD DQAGARINLA LLKRGIIVRP VGNYGLPQWL RISIGLSEEN 370 AAFIDALKAI LAQE

References

[1]

"Complete sequence of Polynucleobacter necessarius STIR1." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M. , Hauser L., Kyrpides N., Kim E., Hahn M., Richardson P. Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: STIR1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001010 Genomic DNA. Translation: ACB44432.1.
RefSeq	YP_001798046.1. NC_010531.1.
3D structure databases
ProteinModelPortal	B1XVQ5.
ModBase	Search...
Protein-protein interaction databases
STRING	B1XVQ5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6183478.
GenomeReviews	Gene locus Pnec_1312 in contig CP001010_GR.
KEGG	pne:Pnec_1312.
PATRIC	22971814. VBIPolNec8289_1507.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG646350.
OMA	ENPLGMP.
ProtClustDB	PRK02731.
Family and domain databases
HAMAP	MF_01023. HisC_aminotrans_2. [Tree]
InterPro	IPR004839. Aminotransferase_I/II. IPR005861. HisP_aminotrans. IPR004838. NHTrfase_class1_PyrdxlP-BS. IPR015424. PyrdxlP-dep_Trfase_major_dom. IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR015422. PyrdxlP-dep_Trfase_major_sub2. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit. G3DSA:3.90.1150.10. PyrdxlP-dep_Trfase_major_sub2. 1 hit.
KO	K00817.
Pfam	PF00155. Aminotran_1_2. 1 hit. [Graphical view]
SUPFAM	SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
TIGRFAMs	TIGR01141. HisC. 1 hit.
PROSITE	PS00105. AA_TRANSFER_CLASS_1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

B1XVQ5_POLNS

Accession

Primary (citable) accession number: B1XVQ5

Entry history

Integrated into UniProtKB/TrEMBL:	May 20, 2008
Last sequence update:	May 20, 2008
Last modified:	December 14, 2011
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)