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Protein

Ribosomal RNA large subunit methyltransferase H

Gene

rlmH

Organism
Polynucleobacter necessarius subsp. necessarius (strain STIR1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + pseudouridine(1915) in 23S rRNA = S-adenosyl-L-homocysteine + N3-methylpseudouridine(1915) in 23S rRNA.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei52S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation1
Binding sitei83S-adenosyl-L-methionine; via amide nitrogenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processrRNA processing
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciPNEC452638:G1GBJ-1191-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosomal RNA large subunit methyltransferase HUniRule annotation (EC:2.1.1.177UniRule annotation)
Alternative name(s):
23S rRNA (pseudouridine1915-N3)-methyltransferaseUniRule annotation
23S rRNA m3Psi1915 methyltransferaseUniRule annotation
rRNA (pseudouridine-N3-)-methyltransferase RlmHUniRule annotation
Gene namesi
Name:rlmHUniRule annotation
Ordered Locus Names:Pnec_1242
OrganismiPolynucleobacter necessarius subsp. necessarius (strain STIR1)
Taxonomic identifieri452638 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaePolynucleobacter
Proteomesi
  • UP000006582 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003666351 – 135Ribosomal RNA large subunit methyltransferase HAdd BLAST135

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi452638.Pnec_1242

Structurei

3D structure databases

ProteinModelPortaliB1XVK0
SMRiB1XVK0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni102 – 107S-adenosyl-L-methionine bindingUniRule annotation6

Sequence similaritiesi

Belongs to the RNA methyltransferase RlmH family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108UXA Bacteria
COG1576 LUCA
HOGENOMiHOG000218434
KOiK00783
OMAiGINQYKK
OrthoDBiPOG091H028B

Family and domain databases

Gene3Di3.40.1280.101 hit
HAMAPiMF_00658 23SrRNA_methyltr_H, 1 hit
InterProiView protein in InterPro
IPR029028 Alpha/beta_knot_MTases
IPR003742 RlmH-like
IPR029026 tRNA_m1G_MTases_N
PANTHERiPTHR33603 PTHR33603, 1 hit
PfamiView protein in Pfam
PF02590 SPOUT_MTase, 1 hit
PIRSFiPIRSF004505 MT_bac, 1 hit
SUPFAMiSSF75217 SSF75217, 1 hit

Sequencei

Sequence statusi: Complete.

B1XVK0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLTIVSVGH KMPDWVATAT IEIKEIKPDL TLAKEAVKIA AAIPKGSRVI
60 70 80 90 100
ALDERGKDQT TQNLATQLAS WRQEGFDITF LIGGADGLDP SLKTTAQAIW
110 120 130
RLSSLTLPHA MARVLLVEQL YRAWTILQGH PYHRE
Length:135
Mass (Da):14,982
Last modified:May 20, 2008 - v1
Checksum:i2B040AB1CA8FB6CA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001010 Genomic DNA Translation: ACB44377.1
RefSeqiWP_012358140.1, NC_010531.1

Genome annotation databases

EnsemblBacteriaiACB44377; ACB44377; Pnec_1242
KEGGipne:Pnec_1242

Similar proteinsi

Entry informationi

Entry nameiRLMH_POLNS
AccessioniPrimary (citable) accession number: B1XVK0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: May 20, 2008
Last modified: February 28, 2018
This is version 56 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome