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Protein

Pantothenate synthetase

Gene

panC

Organism
Polynucleobacter necessarius subsp. necessarius (strain STIR1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.UniRule annotation

Miscellaneous

The reaction proceeds by a bi uni uni bi ping pong mechanism.UniRule annotation

Catalytic activityi

ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.UniRule annotation

Pathwayi: (R)-pantothenate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes (R)-pantothenate from (R)-pantoate and beta-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Pantothenate synthetase (panC)
This subpathway is part of the pathway (R)-pantothenate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (R)-pantothenate from (R)-pantoate and beta-alanine, the pathway (R)-pantothenate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei33Proton donorUniRule annotation1
Binding sitei57Beta-alanineUniRule annotation1
Binding sitei57PantoateUniRule annotation1
Binding sitei150PantoateUniRule annotation1
Binding sitei173ATP; via amide nitrogen and carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi26 – 33ATPUniRule annotation8
Nucleotide bindingi144 – 147ATPUniRule annotation4
Nucleotide bindingi181 – 184ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processPantothenate biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPNEC452638:G1GBJ-1162-MONOMER
UniPathwayiUPA00028; UER00005

Names & Taxonomyi

Protein namesi
Recommended name:
Pantothenate synthetaseUniRule annotation (EC:6.3.2.1UniRule annotation)
Short name:
PSUniRule annotation
Alternative name(s):
Pantoate--beta-alanine ligaseUniRule annotation
Pantoate-activating enzymeUniRule annotation
Gene namesi
Name:panCUniRule annotation
Ordered Locus Names:Pnec_1212
OrganismiPolynucleobacter necessarius subsp. necessarius (strain STIR1)
Taxonomic identifieri452638 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaePolynucleobacter
Proteomesi

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000970851 – 283Pantothenate synthetaseAdd BLAST283

Proteomic databases

PRIDEiB1XVH8

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi452638.Pnec_1212

Structurei

3D structure databases

ProteinModelPortaliB1XVH8
SMRiB1XVH8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the pantothenate synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108IAA Bacteria
COG0414 LUCA
HOGENOMiHOG000175516
KOiK01918
OMAiLFNMVQP
OrthoDBiPOG091H00FM

Family and domain databases

CDDicd00560 PanC, 1 hit
Gene3Di3.40.50.620, 1 hit
HAMAPiMF_00158 PanC, 1 hit
InterProiView protein in InterPro
IPR004821 Cyt_trans-like
IPR003721 Pantoate_ligase
IPR014729 Rossmann-like_a/b/a_fold
PANTHERiPTHR21299:SF1 PTHR21299:SF1, 1 hit
PfamiView protein in Pfam
PF02569 Pantoate_ligase, 1 hit
TIGRFAMsiTIGR00125 cyt_tran_rel, 1 hit
TIGR00018 panC, 1 hit

Sequencei

Sequence statusi: Complete.

B1XVH8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIISDIQEL RDHLRGQNRA SFVPTMGNLH EGHLSLMRLA RQHGDPVVAS
60 70 80 90 100
IFVNRLQFGP NEDFDSYPRT MQADIDKLEK EGVYILFAPT ERDLYPQPQE
110 120 130 140 150
YRVDPPQQLG DILEGEFRPG FFKGVCTVVL KLFSCVQPKV AVFGKKDYQQ
160 170 180 190 200
LMIIHQMAKQ FALPVEIIPG ETIRAEDGLA LSSRNGYLSA EERAEAPELI
210 220 230 240 250
KALKEVRQRV LDSNIRDAKT ISEIEKLAVA SLAGRGWKLD YIAIRQQSNL
260 270 280
APASNEQLQA GDPLVILTAA KLGKTRLIDN LEI
Length:283
Mass (Da):31,790
Last modified:May 20, 2008 - v1
Checksum:i6E19C69E165531B3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001010 Genomic DNA Translation: ACB44355.1
RefSeqiWP_012358118.1, NC_010531.1

Genome annotation databases

EnsemblBacteriaiACB44355; ACB44355; Pnec_1212
KEGGipne:Pnec_1212

Similar proteinsi

Entry informationi

Entry nameiPANC_POLNS
AccessioniPrimary (citable) accession number: B1XVH8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: May 20, 2008
Last modified: May 23, 2018
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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