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Protein

Malate dehydrogenase

Gene

mdh

Organism
Polynucleobacter necessarius subsp. necessarius (strain STIR1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei95SubstrateUniRule annotation1
Binding sitei101SubstrateUniRule annotation1
Binding sitei108NADUniRule annotation1
Binding sitei115NADUniRule annotation1
Binding sitei134SubstrateUniRule annotation1
Binding sitei165SubstrateUniRule annotation1
Active sitei190Proton acceptorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi12 – 18NADUniRule annotation7
Nucleotide bindingi132 – 134NADUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processTricarboxylic acid cycle
LigandNAD

Enzyme and pathway databases

BioCyciPNEC452638:G1GBJ-1034-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
Gene namesi
Name:mdhUniRule annotation
Ordered Locus Names:Pnec_1065
OrganismiPolynucleobacter necessarius subsp. necessarius (strain STIR1)
Taxonomic identifieri452638 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaePolynucleobacter
Proteomesi
  • UP000006582 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001916271 – 329Malate dehydrogenaseAdd BLAST329

Proteomic databases

PRIDEiB1XV63

Interactioni

Protein-protein interaction databases

STRINGi452638.Pnec_1065

Structurei

3D structure databases

ProteinModelPortaliB1XV63
SMRiB1XV63
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 2 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105D9Z Bacteria
COG0039 LUCA
HOGENOMiHOG000220953
KOiK00024
OMAiRPRTKGM
OrthoDBiPOG091H03R4

Family and domain databases

Gene3Di3.90.110.10, 1 hit
HAMAPiMF_01517 Malate_dehydrog_2, 1 hit
InterProiView protein in InterPro
IPR001557 L-lactate/malate_DH
IPR022383 Lactate/malate_DH_C
IPR001236 Lactate/malate_DH_N
IPR015955 Lactate_DH/Glyco_Ohase_4_C
IPR010945 Malate_DH_type2
IPR036291 NAD(P)-bd_dom_sf
PANTHERiPTHR23382 PTHR23382, 1 hit
PfamiView protein in Pfam
PF02866 Ldh_1_C, 1 hit
PF00056 Ldh_1_N, 1 hit
PIRSFiPIRSF000102 Lac_mal_DH, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
SSF56327 SSF56327, 1 hit
TIGRFAMsiTIGR01759 MalateDH-SF1, 1 hit

Sequencei

Sequence statusi: Complete.

B1XV63-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKAPMRVAV TGAAGQIGYS LLFRIANGDL LGKDQPVILQ LLEIPDEKAQ
60 70 80 90 100
KALAGVMMEL EDCAFPLLAG MTAHSDPMTA FKDIDVALLV GARPRGPGME
110 120 130 140 150
RKDLLSANAQ IFTAQGKALN VVAKKTVKVL VVGNPANTNA YIAMKSAPDI
160 170 180 190 200
PAKNFTAMLR LDHNRALSQL ANKLNKPVAD IEKLVVWGNH SPTMYPDYRF
210 220 230 240 250
ATIDGKSVKD SINDAAWNKD VFIPTVGKRG AAIIEARGLS SAASAANAAI
260 270 280 290 300
DHIHDWVLGT NGKWVTMGIP SKGEYDIPAE VIYGFPVVCE NGEYKMIEGL
310 320
EIDEFSRERM THTLNELLEE QAGVKHLLS
Length:329
Mass (Da):35,546
Last modified:May 20, 2008 - v1
Checksum:i318BDD3C44157720
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001010 Genomic DNA Translation: ACB44240.1
RefSeqiWP_012358003.1, NC_010531.1

Genome annotation databases

EnsemblBacteriaiACB44240; ACB44240; Pnec_1065
KEGGipne:Pnec_1065

Similar proteinsi

Entry informationi

Entry nameiMDH_POLNS
AccessioniPrimary (citable) accession number: B1XV63
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: May 20, 2008
Last modified: May 23, 2018
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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