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B1XT79

- GSA_POLNS

UniProt

B1XT79 - GSA_POLNS

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Protein

Glutamate-1-semialdehyde 2,1-aminomutase

Gene
hemL, Pnec_0261
Organism
Polynucleobacter necessarius subsp. necessarius (strain STIR1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-4-amino-5-oxopentanoate = 5-aminolevulinate.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. glutamate-1-semialdehyde 2,1-aminomutase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: InterPro
  3. transaminase activity Source: InterPro

GO - Biological processi

  1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Porphyrin biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciPNEC452638:GI4T-270-MONOMER.
UniPathwayiUPA00251; UER00317.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate-1-semialdehyde 2,1-aminomutase (EC:5.4.3.8)
Short name:
GSA
Alternative name(s):
Glutamate-1-semialdehyde aminotransferase
Short name:
GSA-AT
Gene namesi
Name:hemL
Ordered Locus Names:Pnec_0261
OrganismiPolynucleobacter necessarius subsp. necessarius (strain STIR1)
Taxonomic identifieri452638 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaePolynucleobacter
ProteomesiUP000006582: Chromosome

Subcellular locationi

Cytoplasm Reviewed prediction UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 433433Glutamate-1-semialdehyde 2,1-aminomutaseUniRule annotationPRO_0000382357Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei273 – 2731N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi452638.Pnec_0261.

Structurei

3D structure databases

ProteinModelPortaliB1XT79.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0001.
HOGENOMiHOG000020210.
KOiK01845.
OMAiLMAHIAP.
OrthoDBiEOG6QVRHN.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPiMF_00375. HemL_aminotrans_3.
InterProiIPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 1 hit.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR00713. hemL. 1 hit.
PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B1XT79-1 [UniParc]FASTAAdd to Basket

« Hide

MAKVDQNEAL FERAQKTIPG GVNSPVRAFR QVGGIPRFVA KAKGSYFWDA    50
NDQRYIDLIM SWGPMIVGHA NPEVVAAVQK AAETSFSYGA PTEGEIELAE 100
RICALMPSVE QVRMVSSGTE ATMSALRLAR GYTGRDLIIK FEGCYHGHAD 150
SLLVKVGSGL LTFADSTQNA PSSGGVPQDL VKHTLVLPYN DVAAIEEVFQ 200
KQGDQIAAVI IEPIAGNMNL IQPSKAFLAA IRTLTAKHGA VLIYDEVMTG 250
FRVALGGAQS LQGITPDLTC LGKVMGGGMP MAAFGGKKEI MSKLAPLGNV 300
YQAGTLSGNP VAVAAGLKTL EIVSREGFYE CLTGQTQKLM AGLKAAADNN 350
TVPFTVDSVG GMFGFYFVDQ VPTSYEAVTK TNIDAFKKFF HLMLDEGVYL 400
APSAYEAGFI SIAHDNAVLE EIIAAAESSF KKL 433
Length:433
Mass (Da):46,122
Last modified:May 20, 2008 - v1
Checksum:i41C3C4827EAB30E9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001010 Genomic DNA. Translation: ACB43556.1.
RefSeqiYP_001797170.1. NC_010531.1.

Genome annotation databases

EnsemblBacteriaiACB43556; ACB43556; Pnec_0261.
GeneIDi6184081.
KEGGipne:Pnec_0261.
PATRICi22969367. VBIPolNec8289_0312.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001010 Genomic DNA. Translation: ACB43556.1 .
RefSeqi YP_001797170.1. NC_010531.1.

3D structure databases

ProteinModelPortali B1XT79.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 452638.Pnec_0261.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACB43556 ; ACB43556 ; Pnec_0261 .
GeneIDi 6184081.
KEGGi pne:Pnec_0261.
PATRICi 22969367. VBIPolNec8289_0312.

Phylogenomic databases

eggNOGi COG0001.
HOGENOMi HOG000020210.
KOi K01845.
OMAi LMAHIAP.
OrthoDBi EOG6QVRHN.

Enzyme and pathway databases

UniPathwayi UPA00251 ; UER00317 .
BioCyci PNEC452638:GI4T-270-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPi MF_00375. HemL_aminotrans_3.
InterProi IPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
PANTHERi PTHR11986. PTHR11986. 1 hit.
Pfami PF00202. Aminotran_3. 1 hit.
[Graphical view ]
PIRSFi PIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR00713. hemL. 1 hit.
PROSITEi PS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: STIR1.

Entry informationi

Entry nameiGSA_POLNS
AccessioniPrimary (citable) accession number: B1XT79
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: May 20, 2008
Last modified: May 14, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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