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B1XT75 (B1XT75_POLNS) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 33. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Gamma-glutamyl phosphate reductase HAMAP MF_00412
Short name=GPR HAMAP MF_00412
EC=1.2.1.41 HAMAP MF_00412
Alternative name(s):
Glutamate-5-semialdehyde dehydrogenase HAMAP MF_00412
Glutamyl-gamma-semialdehyde dehydrogenase HAMAP MF_00412
Gene names
Name:proA HAMAP MF_00412
Ordered Locus Names:Pnec_0257
OrganismPolynucleobacter necessarius (strain STIR1) [Complete proteome] [HAMAP]
Taxonomic identifier452638 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Polynucleobacter

Protein attributes

Sequence length425 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the NADPH dependent reduction of L-gamma-glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate By similarity. HAMAP MF_00412 SAAS SAAS020593

Catalytic activity

L-glutamate 5-semialdehyde + phosphate + NADP+ = L-glutamyl 5-phosphate + NADPH. HAMAP MF_00412 SAAS SAAS020593

Pathway

Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2. HAMAP MF_00412 SAAS SAAS020593

Subcellular location

Cytoplasm By similarity HAMAP MF_00412 SAAS SAAS020593.

Sequence similarities

Belongs to the gamma-glutamyl phosphate reductase family. HAMAP MF_00412

Sequences

Sequence LengthMass (Da)Tools
B1XT75 [UniParc].

Last modified May 20, 2008. Version 1.
Checksum: 5FE3F4482165D300

FASTA42545,902
        10         20         30         40         50         60 
MSSAIKEMMQ DIGMRARAAS RAMARASSEQ KNQALLHIAK VIRQKADEIQ KVNLVDVERA 

        70         80         90        100        110        120 
KANGQDAAFV DRLTMTSKTI ETMALGLEQI VSLDDPIGKI TPLQKQASGI ELGQMRVPLG 

       130        140        150        160        170        180 
VIGIIYESRP NVTIDAATLC LKSGNAVILR GGSEAIDSNT LLAQIIQGGL AAAGLPKDAV 

       190        200        210        220        230        240 
QVVATTDRSA VGEMITMTQY IDVIVPRGGK SLIARLMAEA RVPMIKHLDG ICHTYIDADV 

       250        260        270        280        290        300 
DVAMAVKVCD NAKTQRYAPC NAMETLLVNQ EIAQKVLPTL CKIYQDKGVE LRVDGLTRKT 

       310        320        330        340        350        360 
LEANGFQNLA DAKEGDWQTE YLAPILSIKT VADIDEAMNH IEQYGSKHTD AIITNNQAKA 

       370        380        390        400        410        420 
DRFLREVDSA SVMVNASTRF ADGFEYGLGA EIGISNDKLH ARGPVGLDGL TSLKYVVMGH 


GEIRT

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References

[1]"Complete sequence of Polynucleobacter necessarius STIR1."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Kim E., Hahn M., Richardson P.
Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: STIR1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001010 Genomic DNA. Translation: ACB43552.1.
RefSeqYP_001797166.1. NC_010531.1.

3D structure databases

ProteinModelPortalB1XT75.
ModBaseSearch...

Protein-protein interaction databases

STRINGB1XT75.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6184368.
GenomeReviewsGene locus Pnec_0257 in contig CP001010_GR.
KEGGpne:Pnec_0257.
PATRIC22969357. VBIPolNec8289_0307.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG318080.
OMAYGICGAM.
ProtClustDBPRK00197.

Family and domain databases

HAMAPMF_00412. ProA.
[Tree]
InterProIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR000965. G-glutamylP_reductase.
IPR020593. G-glutamylP_reductase_CS.
IPR012134. Glu-5-SA_DH.
[Graphical view]
Gene3DG3DSA:3.40.309.10. Aldehyde_dehydrogenase_C. 1 hit.
G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 2 hits.
KOK00147.
PANTHERPTHR11063:SF1. GSA_DH. 1 hit.
PfamPF00171. Aldedh. 2 hits.
[Graphical view]
PIRSFPIRSF000151. GPR. 1 hit.
SUPFAMSSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
TIGRFAMsTIGR00407. ProA. 1 hit.
PROSITEPS01223. PROA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameB1XT75_POLNS
AccessionPrimary (citable) accession number: B1XT75
Entry history
Integrated into UniProtKB/TrEMBL: May 20, 2008
Last sequence update: May 20, 2008
Last modified: December 14, 2011
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info