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B1XT72

- SYL_POLNS

UniProt

B1XT72 - SYL_POLNS

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Polynucleobacter necessarius subsp. necessarius (strain STIR1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei648 – 6481ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPNEC452638:GI4T-263-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Pnec_0254
OrganismiPolynucleobacter necessarius subsp. necessarius (strain STIR1)
Taxonomic identifieri452638 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaePolynucleobacter
ProteomesiUP000006582: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 890890Leucine--tRNA ligasePRO_1000091342Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi452638.Pnec_0254.

Structurei

3D structure databases

ProteinModelPortaliB1XT72.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi48 – 5811"HIGH" regionAdd
BLAST
Motifi645 – 6495"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiPVIHCPK.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B1XT72-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSKDYDYRSI EAAAQADWEG AQVYQVAENA VDAQGKKKSK YYACSMLPYP
60 70 80 90 100
SGKLHMGHVR NYTINDVMAR QLRMQGYNVL MPMGWDAFGM PAENAAIQNK
110 120 130 140 150
VPPAKWTYDN IAYMKKQMAA MGLAIDWSRE VATCNPDYYR WNQWLFLKML
160 170 180 190 200
EKGIAYRKTQ VVNWDPIDQT VLANEQVIDG RGWRSGALVE KREIPGYYFN
210 220 230 240 250
ITAYAEPLLS GLDGLGWPER VKTMQQNWIG KSRGVRFAFK HEIADDYGNF
260 270 280 290 300
IQDGLLYVFT TRADTIMGVT FCAVAAEHPL ATKAAANNSA LAAFIEKCKT
310 320 330 340 350
GSVIEADLAT QEKEGMFTGL YVTHPLTYEP VPVWVGNYVL MSYGDGAVMG
360 370 380 390 400
VPAHDERDFA FALKYELPIK QVIALKDESP MFNATCWEDW YAQKDGVVCF
410 420 430 440 450
NSAQFDGLSH EEAVSAVAKA LEKLGIGDIK TSFRLRDWGI SRQRYWGTPI
460 470 480 490 500
PIIHCGDESN PGCGAVPVPE ADLPVVLPED CVPDGSGNPL NKRADFLSVK
510 520 530 540 550
CPKCGKPARR ETDTMDTFVD SSWYFMRYTG PNAKTMVDER NEYWMPMDQY
560 570 580 590 600
IGGIEHAILH LLYARFWTKI MRDLNLITFD EPFQNLLTQG MVLNETYYSE
610 620 630 640 650
DASGKKTWLN PLDVELDLDE KGRPKGAKLI GDTLNTPVVV GGVEKMSKSK
660 670 680 690 700
NNGVDPQALI DEYGADTARL FVMFAAPPEQ QLEWSGAGVD GASRFLRRVW
710 720 730 740 750
MYFSGQASAL RDASDSLPSN LNDAEKELRR EVHTILKQAN FDYQRRQYNT
760 770 780 790 800
VVSAAMKMLN ILEPIKLDQN AAISAPVLRE CLSILLRVLY PVVPHLTHVL
810 820 830 840 850
WKEVGYAKTM GPLLDAPWPT VDEATLVQTE ITLMLQINGK LRGDIKVPAD
860 870 880 890
ANKEQVEALA LQSEPAQKAL NGGAPKKVIV VPGRLVNIVA
Length:890
Mass (Da):99,540
Last modified:May 20, 2008 - v1
Checksum:i2CCD3CC373DE5E60
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001010 Genomic DNA. Translation: ACB43549.1.
RefSeqiYP_001797163.1. NC_010531.1.

Genome annotation databases

EnsemblBacteriaiACB43549; ACB43549; Pnec_0254.
GeneIDi6184601.
KEGGipne:Pnec_0254.
PATRICi22969351. VBIPolNec8289_0304.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001010 Genomic DNA. Translation: ACB43549.1 .
RefSeqi YP_001797163.1. NC_010531.1.

3D structure databases

ProteinModelPortali B1XT72.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 452638.Pnec_0254.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACB43549 ; ACB43549 ; Pnec_0254 .
GeneIDi 6184601.
KEGGi pne:Pnec_0254.
PATRICi 22969351. VBIPolNec8289_0304.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi PVIHCPK.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci PNEC452638:GI4T-263-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: STIR1.

Entry informationi

Entry nameiSYL_POLNS
AccessioniPrimary (citable) accession number: B1XT72
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: May 20, 2008
Last modified: October 29, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3