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B1XSN1

- FMT_POLNS

UniProt

B1XSN1 - FMT_POLNS

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Protein
Methionyl-tRNA formyltransferase
Gene
fmt, Pnec_1777
Organism
Polynucleobacter necessarius subsp. necessarius (strain STIR1)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by: (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP By similarity.UniRule annotation

Catalytic activityi

10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = tetrahydrofolate + N-formylmethionyl-tRNA(fMet).UniRule annotation

GO - Molecular functioni

  1. methionyl-tRNA formyltransferase activity Source: UniProtKB-HAMAP
  2. methyltransferase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Protein biosynthesis

Enzyme and pathway databases

BioCyciPNEC452638:GI4T-1773-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Methionyl-tRNA formyltransferase (EC:2.1.2.9)
Gene namesi
Name:fmt
Ordered Locus Names:Pnec_1777
OrganismiPolynucleobacter necessarius subsp. necessarius (strain STIR1)
Taxonomic identifieri452638 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaePolynucleobacter
ProteomesiUP000006582: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 332332Methionyl-tRNA formyltransferaseUniRule annotation
PRO_1000098425Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi452638.Pnec_1777.

Structurei

3D structure databases

ProteinModelPortaliB1XSN1.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni124 – 1274Tetrahydrofolate (THF) binding By similarity

Sequence similaritiesi

Belongs to the Fmt family.

Phylogenomic databases

eggNOGiCOG0223.
HOGENOMiHOG000261177.
KOiK00604.
OMAiAESTIDW.
OrthoDBiEOG6B09WV.

Family and domain databases

Gene3Di3.10.25.10. 1 hit.
3.40.50.170. 1 hit.
HAMAPiMF_00182. Formyl_trans.
InterProiIPR005794. Fmt.
IPR005793. Formyl_trans_C.
IPR002376. Formyl_transf_N.
IPR011034. Formyl_transferase_C-like.
IPR001555. GART_AS.
IPR015518. Met_tRNA_Form_TA-like.
[Graphical view]
PANTHERiPTHR11138. PTHR11138. 1 hit.
PfamiPF02911. Formyl_trans_C. 1 hit.
PF00551. Formyl_trans_N. 1 hit.
[Graphical view]
SUPFAMiSSF50486. SSF50486. 1 hit.
SSF53328. SSF53328. 1 hit.
TIGRFAMsiTIGR00460. fmt. 1 hit.
PROSITEiPS00373. GART. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B1XSN1-1 [UniParc]FASTAAdd to Basket

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MKIVFAGTPE FAAQAVRAIH AAGHEIVLAF TQPDRRAGRG MHLQASPVKE    50
FALQKNIPIL QPETLRRTSA DPQKKAQAEE AYKSLSAIEF DAMVVVAYGL 100
ILPQEILDIT EKPGRHGSFN IHASLLPRWR GAAPIQRAIE AGDAKTGVCI 150
MQMDAGLDTG DTVLVVELDI ARDETSASLH DRLAGLGADL IVNALDVLQQ 200
GKTMIRSPQA IKGITYAEKI LKSEAEIDWT LSAQEIDQRI RAFNPFPGAS 250
SKLNGYAIKL WNSRLADSQA FSMVGGAGDV LEFGRDGAYI QCGEGVLEVL 300
EMQKPGGKKM AAKACIQPIG AGEKLLHFQL KE 332
Length:332
Mass (Da):35,891
Last modified:May 20, 2008 - v1
Checksum:i5699A912ECC23449
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001010 Genomic DNA. Translation: ACB44830.1.
RefSeqiYP_001798444.1. NC_010531.1.

Genome annotation databases

EnsemblBacteriaiACB44830; ACB44830; Pnec_1777.
GeneIDi6183844.
KEGGipne:Pnec_1777.
PATRICi22972892. VBIPolNec8289_2039.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001010 Genomic DNA. Translation: ACB44830.1 .
RefSeqi YP_001798444.1. NC_010531.1.

3D structure databases

ProteinModelPortali B1XSN1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 452638.Pnec_1777.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACB44830 ; ACB44830 ; Pnec_1777 .
GeneIDi 6183844.
KEGGi pne:Pnec_1777.
PATRICi 22972892. VBIPolNec8289_2039.

Phylogenomic databases

eggNOGi COG0223.
HOGENOMi HOG000261177.
KOi K00604.
OMAi AESTIDW.
OrthoDBi EOG6B09WV.

Enzyme and pathway databases

BioCyci PNEC452638:GI4T-1773-MONOMER.

Family and domain databases

Gene3Di 3.10.25.10. 1 hit.
3.40.50.170. 1 hit.
HAMAPi MF_00182. Formyl_trans.
InterProi IPR005794. Fmt.
IPR005793. Formyl_trans_C.
IPR002376. Formyl_transf_N.
IPR011034. Formyl_transferase_C-like.
IPR001555. GART_AS.
IPR015518. Met_tRNA_Form_TA-like.
[Graphical view ]
PANTHERi PTHR11138. PTHR11138. 1 hit.
Pfami PF02911. Formyl_trans_C. 1 hit.
PF00551. Formyl_trans_N. 1 hit.
[Graphical view ]
SUPFAMi SSF50486. SSF50486. 1 hit.
SSF53328. SSF53328. 1 hit.
TIGRFAMsi TIGR00460. fmt. 1 hit.
PROSITEi PS00373. GART. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: STIR1.

Entry informationi

Entry nameiFMT_POLNS
AccessioniPrimary (citable) accession number: B1XSN1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: May 20, 2008
Last modified: May 14, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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