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Protein

Methionyl-tRNA formyltransferase

Gene

fmt

Organism
Polynucleobacter necessarius subsp. necessarius (strain STIR1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.UniRule annotation

Catalytic activityi

10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = tetrahydrofolate + N-formylmethionyl-tRNA(fMet).UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionTransferase
Biological processProtein biosynthesis

Enzyme and pathway databases

BioCyciPNEC452638:G1GBJ-1689-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Methionyl-tRNA formyltransferaseUniRule annotation (EC:2.1.2.9UniRule annotation)
Gene namesi
Name:fmtUniRule annotation
Ordered Locus Names:Pnec_1777
OrganismiPolynucleobacter necessarius subsp. necessarius (strain STIR1)
Taxonomic identifieri452638 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaePolynucleobacter
Proteomesi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000984251 – 332Methionyl-tRNA formyltransferaseAdd BLAST332

Proteomic databases

PRIDEiB1XSN1

Interactioni

Protein-protein interaction databases

STRINGi452638.Pnec_1777

Structurei

3D structure databases

ProteinModelPortaliB1XSN1
SMRiB1XSN1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni124 – 127Tetrahydrofolate (THF) bindingUniRule annotation4

Sequence similaritiesi

Belongs to the Fmt family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CAE Bacteria
COG0223 LUCA
HOGENOMiHOG000261177
KOiK00604
OMAiLRIVFMG
OrthoDBiPOG091H01YM

Family and domain databases

Gene3Di3.10.25.10, 1 hit
HAMAPiMF_00182 Formyl_trans, 1 hit
InterProiView protein in InterPro
IPR005794 Fmt
IPR005793 Formyl_trans_C
IPR037022 Formyl_trans_C_sf
IPR002376 Formyl_transf_N
IPR036477 Formyl_transf_N_sf
IPR011034 Formyl_transferase-like_C_sf
IPR001555 GART_AS
PfamiView protein in Pfam
PF02911 Formyl_trans_C, 1 hit
PF00551 Formyl_trans_N, 1 hit
SUPFAMiSSF50486 SSF50486, 1 hit
SSF53328 SSF53328, 1 hit
TIGRFAMsiTIGR00460 fmt, 1 hit
PROSITEiView protein in PROSITE
PS00373 GART, 1 hit

Sequencei

Sequence statusi: Complete.

B1XSN1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIVFAGTPE FAAQAVRAIH AAGHEIVLAF TQPDRRAGRG MHLQASPVKE
60 70 80 90 100
FALQKNIPIL QPETLRRTSA DPQKKAQAEE AYKSLSAIEF DAMVVVAYGL
110 120 130 140 150
ILPQEILDIT EKPGRHGSFN IHASLLPRWR GAAPIQRAIE AGDAKTGVCI
160 170 180 190 200
MQMDAGLDTG DTVLVVELDI ARDETSASLH DRLAGLGADL IVNALDVLQQ
210 220 230 240 250
GKTMIRSPQA IKGITYAEKI LKSEAEIDWT LSAQEIDQRI RAFNPFPGAS
260 270 280 290 300
SKLNGYAIKL WNSRLADSQA FSMVGGAGDV LEFGRDGAYI QCGEGVLEVL
310 320 330
EMQKPGGKKM AAKACIQPIG AGEKLLHFQL KE
Length:332
Mass (Da):35,891
Last modified:May 20, 2008 - v1
Checksum:i5699A912ECC23449
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001010 Genomic DNA Translation: ACB44830.1
RefSeqiWP_012358588.1, NC_010531.1

Genome annotation databases

EnsemblBacteriaiACB44830; ACB44830; Pnec_1777
KEGGipne:Pnec_1777

Entry informationi

Entry nameiFMT_POLNS
AccessioniPrimary (citable) accession number: B1XSN1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: May 20, 2008
Last modified: March 28, 2018
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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