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B1XS23

- PUR9_POLNS

UniProt

B1XS23 - PUR9_POLNS

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Protein
Bifunctional purine biosynthesis protein PurH
Gene
purH, Pnec_1581
Organism
Polynucleobacter necessarius subsp. necessarius (strain STIR1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

BioCyciPNEC452638:GI4T-1580-MONOMER.
UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurH
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC:2.1.2.3)
Alternative name(s):
AICAR transformylase
IMP cyclohydrolase (EC:3.5.4.10)
Alternative name(s):
ATIC
IMP synthase
Inosinicase
Gene namesi
Name:purH
Ordered Locus Names:Pnec_1581
OrganismiPolynucleobacter necessarius subsp. necessarius (strain STIR1)
Taxonomic identifieri452638 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaePolynucleobacter
ProteomesiUP000006582: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 526526Bifunctional purine biosynthesis protein PurHUniRule annotation
PRO_1000096080Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi452638.Pnec_1581.

Structurei

3D structure databases

ProteinModelPortaliB1XS23.

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region By similarity.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.

Phylogenomic databases

eggNOGiCOG0138.
HOGENOMiHOG000230373.
KOiK00602.
OMAiCGVATGP.
OrthoDBiEOG6QCDFF.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

B1XS23-1 [UniParc]FASTAAdd to Basket

« Hide

MIRTALLSVS DKNGIVPFAK SLHEQGIKLI STGGTAKLLA ENGLPVVEIS    50
SLTKFPEMLD GRVKTLHPMV HGGLLARRDF PEHMAALKEY GINTIDMLVI 100
NLYPFNETVA KENCSFEDAV ENIDIGGPAM LRAAAKNHQD VTVLISPEDY 150
APVLAEMKAN QNSVSYKTNL ALAKKVFAHT AQYDGAIANY LSALGDDLDH 200
KARSAYPETL HLAFEKVQEM RYGENPHQAA AFYKDIYPVD GALANYKQLQ 250
GKELSYNNIA DADSAWECVK SFTGNAGGAA ACVIIKHANP CGVAVGASAL 300
EAYQKAFKTD PSSAFGGIIA FNVSCDGAAA EAISKQFVEV LIAPSFSDEA 350
KTIFAAKQNM RLLEIPLGTA FNTFDFKRVG GGLLVQSPDA KNVLENEMCV 400
VSKRLPTPSE MHDMMFAWRV AKFVKSNAII YCANGMTLGI GAGQMSRVDS 450
ARMASIKAKN AGLSLKGSAV ASDAFFPFRD GLDVVVNGGA SCAIQPGGSM 500
RDDEIIAAAD EHGIAMIFTG TRHFRH 526
Length:526
Mass (Da):56,412
Last modified:May 20, 2008 - v1
Checksum:i8C3ACFF62C9A2910
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001010 Genomic DNA. Translation: ACB44658.1.
RefSeqiYP_001798272.1. NC_010531.1.

Genome annotation databases

EnsemblBacteriaiACB44658; ACB44658; Pnec_1581.
GeneIDi6183700.
KEGGipne:Pnec_1581.
PATRICi22972447. VBIPolNec8289_1820.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001010 Genomic DNA. Translation: ACB44658.1 .
RefSeqi YP_001798272.1. NC_010531.1.

3D structure databases

ProteinModelPortali B1XS23.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 452638.Pnec_1581.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACB44658 ; ACB44658 ; Pnec_1581 .
GeneIDi 6183700.
KEGGi pne:Pnec_1581.
PATRICi 22972447. VBIPolNec8289_1820.

Phylogenomic databases

eggNOGi COG0138.
HOGENOMi HOG000230373.
KOi K00602.
OMAi CGVATGP.
OrthoDBi EOG6QCDFF.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .
BioCyci PNEC452638:GI4T-1580-MONOMER.

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: STIR1.

Entry informationi

Entry nameiPUR9_POLNS
AccessioniPrimary (citable) accession number: B1XS23
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: May 20, 2008
Last modified: May 14, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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