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B1XS23

- PUR9_POLNS

UniProt

B1XS23 - PUR9_POLNS

Protein

Bifunctional purine biosynthesis protein PurH

Gene

purH

Organism
Polynucleobacter necessarius subsp. necessarius (strain STIR1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 45 (01 Oct 2014)
      Sequence version 1 (20 May 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
    IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
    2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase, Transferase

    Keywords - Biological processi

    Purine biosynthesis

    Enzyme and pathway databases

    BioCyciPNEC452638:GI4T-1580-MONOMER.
    UniPathwayiUPA00074; UER00133.
    UPA00074; UER00135.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bifunctional purine biosynthesis protein PurHUniRule annotation
    Including the following 2 domains:
    Phosphoribosylaminoimidazolecarboxamide formyltransferaseUniRule annotation (EC:2.1.2.3UniRule annotation)
    Alternative name(s):
    AICAR transformylaseUniRule annotation
    IMP cyclohydrolaseUniRule annotation (EC:3.5.4.10UniRule annotation)
    Alternative name(s):
    ATICUniRule annotation
    IMP synthaseUniRule annotation
    InosinicaseUniRule annotation
    Gene namesi
    Name:purHUniRule annotation
    Ordered Locus Names:Pnec_1581
    OrganismiPolynucleobacter necessarius subsp. necessarius (strain STIR1)
    Taxonomic identifieri452638 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaePolynucleobacter
    ProteomesiUP000006582: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 526526Bifunctional purine biosynthesis protein PurHPRO_1000096080Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi452638.Pnec_1581.

    Structurei

    3D structure databases

    ProteinModelPortaliB1XS23.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domaini

    The IMP cyclohydrolase activity resides in the N-terminal region.UniRule annotation

    Sequence similaritiesi

    Belongs to the PurH family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0138.
    HOGENOMiHOG000230373.
    KOiK00602.
    OMAiCGVATGP.
    OrthoDBiEOG6QCDFF.

    Family and domain databases

    Gene3Di3.40.140.20. 2 hits.
    3.40.50.1380. 1 hit.
    HAMAPiMF_00139. PurH.
    InterProiIPR024051. AICAR_Tfase_dom.
    IPR002695. AICARFT_IMPCHas.
    IPR016193. Cytidine_deaminase-like.
    IPR011607. MGS-like_dom.
    [Graphical view]
    PANTHERiPTHR11692. PTHR11692. 1 hit.
    PfamiPF01808. AICARFT_IMPCHas. 1 hit.
    PF02142. MGS. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
    SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
    SM00851. MGS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52335. SSF52335. 1 hit.
    SSF53927. SSF53927. 1 hit.
    TIGRFAMsiTIGR00355. purH. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B1XS23-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIRTALLSVS DKNGIVPFAK SLHEQGIKLI STGGTAKLLA ENGLPVVEIS    50
    SLTKFPEMLD GRVKTLHPMV HGGLLARRDF PEHMAALKEY GINTIDMLVI 100
    NLYPFNETVA KENCSFEDAV ENIDIGGPAM LRAAAKNHQD VTVLISPEDY 150
    APVLAEMKAN QNSVSYKTNL ALAKKVFAHT AQYDGAIANY LSALGDDLDH 200
    KARSAYPETL HLAFEKVQEM RYGENPHQAA AFYKDIYPVD GALANYKQLQ 250
    GKELSYNNIA DADSAWECVK SFTGNAGGAA ACVIIKHANP CGVAVGASAL 300
    EAYQKAFKTD PSSAFGGIIA FNVSCDGAAA EAISKQFVEV LIAPSFSDEA 350
    KTIFAAKQNM RLLEIPLGTA FNTFDFKRVG GGLLVQSPDA KNVLENEMCV 400
    VSKRLPTPSE MHDMMFAWRV AKFVKSNAII YCANGMTLGI GAGQMSRVDS 450
    ARMASIKAKN AGLSLKGSAV ASDAFFPFRD GLDVVVNGGA SCAIQPGGSM 500
    RDDEIIAAAD EHGIAMIFTG TRHFRH 526
    Length:526
    Mass (Da):56,412
    Last modified:May 20, 2008 - v1
    Checksum:i8C3ACFF62C9A2910
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001010 Genomic DNA. Translation: ACB44658.1.
    RefSeqiYP_001798272.1. NC_010531.1.

    Genome annotation databases

    EnsemblBacteriaiACB44658; ACB44658; Pnec_1581.
    GeneIDi6183700.
    KEGGipne:Pnec_1581.
    PATRICi22972447. VBIPolNec8289_1820.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001010 Genomic DNA. Translation: ACB44658.1 .
    RefSeqi YP_001798272.1. NC_010531.1.

    3D structure databases

    ProteinModelPortali B1XS23.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 452638.Pnec_1581.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACB44658 ; ACB44658 ; Pnec_1581 .
    GeneIDi 6183700.
    KEGGi pne:Pnec_1581.
    PATRICi 22972447. VBIPolNec8289_1820.

    Phylogenomic databases

    eggNOGi COG0138.
    HOGENOMi HOG000230373.
    KOi K00602.
    OMAi CGVATGP.
    OrthoDBi EOG6QCDFF.

    Enzyme and pathway databases

    UniPathwayi UPA00074 ; UER00133 .
    UPA00074 ; UER00135 .
    BioCyci PNEC452638:GI4T-1580-MONOMER.

    Family and domain databases

    Gene3Di 3.40.140.20. 2 hits.
    3.40.50.1380. 1 hit.
    HAMAPi MF_00139. PurH.
    InterProi IPR024051. AICAR_Tfase_dom.
    IPR002695. AICARFT_IMPCHas.
    IPR016193. Cytidine_deaminase-like.
    IPR011607. MGS-like_dom.
    [Graphical view ]
    PANTHERi PTHR11692. PTHR11692. 1 hit.
    Pfami PF01808. AICARFT_IMPCHas. 1 hit.
    PF02142. MGS. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
    SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
    SM00851. MGS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52335. SSF52335. 1 hit.
    SSF53927. SSF53927. 1 hit.
    TIGRFAMsi TIGR00355. purH. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: STIR1.

    Entry informationi

    Entry nameiPUR9_POLNS
    AccessioniPrimary (citable) accession number: B1XS23
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: May 20, 2008
    Last modified: October 1, 2014
    This is version 45 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3