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B1XS23

- PUR9_POLNS

UniProt

B1XS23 - PUR9_POLNS

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Protein

Bifunctional purine biosynthesis protein PurH

Gene

purH

Organism
Polynucleobacter necessarius subsp. necessarius (strain STIR1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

BioCyciPNEC452638:GI4T-1580-MONOMER.
UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurHUniRule annotation
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferaseUniRule annotation (EC:2.1.2.3UniRule annotation)
Alternative name(s):
AICAR transformylaseUniRule annotation
IMP cyclohydrolaseUniRule annotation (EC:3.5.4.10UniRule annotation)
Alternative name(s):
ATICUniRule annotation
IMP synthaseUniRule annotation
InosinicaseUniRule annotation
Gene namesi
Name:purHUniRule annotation
Ordered Locus Names:Pnec_1581
OrganismiPolynucleobacter necessarius subsp. necessarius (strain STIR1)
Taxonomic identifieri452638 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaePolynucleobacter
ProteomesiUP000006582: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 526526Bifunctional purine biosynthesis protein PurHPRO_1000096080Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi452638.Pnec_1581.

Structurei

3D structure databases

ProteinModelPortaliB1XS23.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0138.
HOGENOMiHOG000230373.
KOiK00602.
OMAiCGVATGP.
OrthoDBiEOG6QCDFF.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

B1XS23-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIRTALLSVS DKNGIVPFAK SLHEQGIKLI STGGTAKLLA ENGLPVVEIS
60 70 80 90 100
SLTKFPEMLD GRVKTLHPMV HGGLLARRDF PEHMAALKEY GINTIDMLVI
110 120 130 140 150
NLYPFNETVA KENCSFEDAV ENIDIGGPAM LRAAAKNHQD VTVLISPEDY
160 170 180 190 200
APVLAEMKAN QNSVSYKTNL ALAKKVFAHT AQYDGAIANY LSALGDDLDH
210 220 230 240 250
KARSAYPETL HLAFEKVQEM RYGENPHQAA AFYKDIYPVD GALANYKQLQ
260 270 280 290 300
GKELSYNNIA DADSAWECVK SFTGNAGGAA ACVIIKHANP CGVAVGASAL
310 320 330 340 350
EAYQKAFKTD PSSAFGGIIA FNVSCDGAAA EAISKQFVEV LIAPSFSDEA
360 370 380 390 400
KTIFAAKQNM RLLEIPLGTA FNTFDFKRVG GGLLVQSPDA KNVLENEMCV
410 420 430 440 450
VSKRLPTPSE MHDMMFAWRV AKFVKSNAII YCANGMTLGI GAGQMSRVDS
460 470 480 490 500
ARMASIKAKN AGLSLKGSAV ASDAFFPFRD GLDVVVNGGA SCAIQPGGSM
510 520
RDDEIIAAAD EHGIAMIFTG TRHFRH
Length:526
Mass (Da):56,412
Last modified:May 20, 2008 - v1
Checksum:i8C3ACFF62C9A2910
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001010 Genomic DNA. Translation: ACB44658.1.
RefSeqiYP_001798272.1. NC_010531.1.

Genome annotation databases

EnsemblBacteriaiACB44658; ACB44658; Pnec_1581.
GeneIDi6183700.
KEGGipne:Pnec_1581.
PATRICi22972447. VBIPolNec8289_1820.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001010 Genomic DNA. Translation: ACB44658.1 .
RefSeqi YP_001798272.1. NC_010531.1.

3D structure databases

ProteinModelPortali B1XS23.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 452638.Pnec_1581.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACB44658 ; ACB44658 ; Pnec_1581 .
GeneIDi 6183700.
KEGGi pne:Pnec_1581.
PATRICi 22972447. VBIPolNec8289_1820.

Phylogenomic databases

eggNOGi COG0138.
HOGENOMi HOG000230373.
KOi K00602.
OMAi CGVATGP.
OrthoDBi EOG6QCDFF.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .
BioCyci PNEC452638:GI4T-1580-MONOMER.

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: STIR1.

Entry informationi

Entry nameiPUR9_POLNS
AccessioniPrimary (citable) accession number: B1XS23
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: May 20, 2008
Last modified: October 1, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3