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B1XPH5 (B1XPH5_SYNP2) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 28. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-oxoacyl-[acyl-carrier-protein] synthase 3 HAMAP MF_01815
EC=2.3.1.180 HAMAP MF_01815
Alternative name(s):
3-oxoacyl-[acyl-carrier-protein] synthase III HAMAP MF_01815
Beta-ketoacyl-ACP synthase III HAMAP MF_01815
Gene names
Name:fabH HAMAP MF_01815 EMBL ACA98532.1
Ordered Locus Names:SYNPCC7002_A0525
OrganismSynechococcus sp. (strain ATCC 27264 / PCC 7002 / PR-6) (Agmenellum quadruplicatum) [Complete proteome] [HAMAP]
Taxonomic identifier32049 [NCBI]
Taxonomic lineageBacteria › Cyanobacteria › Chroococcales › Synechococcus

Protein attributes

Sequence length334 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids By similarity. HAMAP MF_01815

Catalytic activity

Acetyl-CoA + malonyl-[acyl-carrier-protein] = acetoacetyl-[acyl-carrier-protein] + CoA + CO2. HAMAP MF_01815

Pathway

Lipid metabolism; fatty acid biosynthesis. HAMAP MF_01815 SAAS SAAS013747

Subunit structure

Homodimer By similarity. HAMAP MF_01815 SAAS SAAS013747

Subcellular location

Cytoplasm By similarity HAMAP MF_01815 SAAS SAAS013747.

Domain

The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH By similarity. HAMAP MF_01815

Sequence similarities

Belongs to the FabH family. HAMAP MF_01815

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region258 – 2625ACP-binding By similarity HAMAP MF_01815

Sites

Active site1161 By similarity HAMAP MF_01815
Active site2571 By similarity HAMAP MF_01815
Active site2871 By similarity HAMAP MF_01815

Sequences

Sequence LengthMass (Da)Tools
B1XPH5 [UniParc].

Last modified May 20, 2008. Version 1.
Checksum: D5038E0B01DDA83C

FASTA33435,758
        10         20         30         40         50         60 
MKFDGAGIAI TGSGSATPKA VIHNDDLSQL VETSDEWIRT RTGIANRHLL PEDSSLSELA 

        70         80         90        100        110        120 
AEAAKKAIAA AHLHPEEIDL IILATSTPDD LFGSAGKVQQ LIGAKNATAF DLTAACSGFV 

       130        140        150        160        170        180 
FGLVTAAQYL RTGTFQKIVV IGADVLSRWV DWGDRTTCVL FGDGAGAVVC QSSPQDQLLG 

       190        200        210        220        230        240 
FEMYSDGSQN ECLNLAYDGH PKYLIHDVSI QKGGYRAITM NGREVYRFAV AKVPEVIEKT 

       250        260        270        280        290        300 
LFRAGLTTED IDWLILHQAN QRIIDAVAKR LKLPSEKVIA NLQEYGNTSA ASIPIALDEA 

       310        320        330 
VRAGKIKPGQ TVATSGFGAG LSWGSAIFKW GMPH

« Hide

References

[1]"Complete sequence of Synechococcus sp. PCC 7002."
Li T., Zhao J., Zhao C., Liu Z., Zhao F., Marquardt J., Nomura C.T., Persson S., Detter J.C., Richardson P.M., Lanz C., Schuster S.C., Wang J., Li S., Huang X., Cai T., Yu Z., Luo J., Zhao J., Bryant D.A.
Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000951 Genomic DNA. Translation: ACA98532.1.
RefSeqYP_001733788.1. NC_010475.1.

3D structure databases

ProteinModelPortalB1XPH5.
ModBaseSearch...

Protein-protein interaction databases

STRINGB1XPH5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6055818.
GenomeReviewsGene locus SYNPCC7002_A0525 in contig CP000951_GR.
KEGGsyp:SYNPCC7002_A0525.
PATRIC23815508. VBISynSp37135_0714.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG649927.
OMAKEIGAIN.
PhylomeDBB1XPH5.

Family and domain databases

HAMAPMF_01815. FabH.
[Tree]
InterProIPR013751. ACP_syn_III.
IPR013747. ACP_syn_III_C.
IPR004655. FabH_synth.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
Gene3DG3DSA:3.40.47.10. Thiolase-like_subgr. 2 hits.
KOK00648.
PfamPF08545. ACP_syn_III. 1 hit.
PF08541. ACP_syn_III_C. 1 hit.
[Graphical view]
SUPFAMSSF53901. Thiolase-like. 1 hit.
TIGRFAMsTIGR00747. FabH. 1 hit.
ProtoNetSearch...

Entry information

Entry nameB1XPH5_SYNP2
AccessionPrimary (citable) accession number: B1XPH5
Entry history
Integrated into UniProtKB/TrEMBL: May 20, 2008
Last sequence update: May 20, 2008
Last modified: December 14, 2011
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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