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B1XP90

- SYL_SYNP2

UniProt

B1XP90 - SYL_SYNP2

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Synechococcus sp. (strain ATCC 27264 / PCC 7002 / PR-6) (Agmenellum quadruplicatum)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 50 (01 Oct 2014)
      Sequence version 1 (20 May 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei617 – 6171ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSSP32049:GKF7-1695-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:SYNPCC7002_A1694
    OrganismiSynechococcus sp. (strain ATCC 27264 / PCC 7002 / PR-6) (Agmenellum quadruplicatum)
    Taxonomic identifieri32049 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
    ProteomesiUP000001688: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 852852Leucine--tRNA ligasePRO_1000091374Add
    BLAST

    PTM databases

    PhosSiteiP13082028.

    Interactioni

    Protein-protein interaction databases

    STRINGi32049.SYNPCC7002_A1694.

    Structurei

    3D structure databases

    ProteinModelPortaliB1XP90.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi42 – 5211"HIGH" regionAdd
    BLAST
    Motifi614 – 6185"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiYARYHRM.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B1XP90-1 [UniParc]FASTAAdd to Basket

    « Hide

    METRYSAADI EAKWQQQWLE LGLDKTPSQS DKPKFYALSM FPYPSGKLHM    50
    GHVRNYVITD VIARYKRMQG YRVLHPMGWD AFGLPAENAA IDRGIPPAKW 100
    TYQNIAQMRE QLKQLGLSID WDREVATCSP DYYKWTQWLF LQFYKAGLAY 150
    QKEAAVNWDP IDQTVLANEQ VDAEGRSWRS GAIVEKKLLR QWFLKITDYA 200
    EELLQDLNTL DGWPERVKLM QENWIGKSTG AHLEFPVVGS DEKVAVFTTR 250
    LDTVFGVTYV VLAPEHPLVA QVTTPAQKAA VDAFIAEVSQ ESEQDRTADD 300
    KPKKGVATGG MVTNPFTGEE VPILIANYVL YEYGTGAVMG VPAHDSRDCK 350
    FAKENNLPIK MVIIPEGGDA TAVLTEAYTE AGIMVNSGQF DGLVSTEGKK 400
    AIAKFAAENG FGREQIQYRL RDWLISRQRY WGCPIPMIYC DDCGVVPVPD 450
    SDLPVVLPED VEFSARGGSP LAQMADWQAV DCPCCGKAAR RETDTMDTFI 500
    DSSWYFLRYT DANNTEKPFA LDPVNDWMAV DQYVGGIEHA ILHLLYSRFF 550
    TKVVRDRQLV SVDEPFKRLL TQGMVQALTY KNPRTNKYVP ADQVDPNDPK 600
    DPETGEPLTG FYEKMSKSKY NGVDPALVLD KYGADTARMF ILFKAPPEKD 650
    LEWDDADVEG QFRFLNRIWN LVAGYEAAET SVKATGELSK AEKDLRRAVH 700
    TAIKEIQEDL EGDYQFNTAI AELMKLNNAI KDVKCVDSPV YKEAIETLIL 750
    LLAPFAPHIA DELWSNLGHS ESIHTVPFPQ LDETALTVDE ITIVIQILGK 800
    TRGTIQVPAG ISKADLEKTA TASDIAQRYI AGKEIKKVIV VPNKLVNFVI 850
    PK 852
    Length:852
    Mass (Da):95,642
    Last modified:May 20, 2008 - v1
    Checksum:i0E88E0B0431A3D66
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000951 Genomic DNA. Translation: ACA99683.1.
    RefSeqiWP_012307306.1. NC_010475.1.
    YP_001734939.1. NC_010475.1.

    Genome annotation databases

    EnsemblBacteriaiACA99683; ACA99683; SYNPCC7002_A1694.
    GeneIDi6057022.
    KEGGisyp:SYNPCC7002_A1694.
    PATRICi23818014. VBISynSp37135_1949.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000951 Genomic DNA. Translation: ACA99683.1 .
    RefSeqi WP_012307306.1. NC_010475.1.
    YP_001734939.1. NC_010475.1.

    3D structure databases

    ProteinModelPortali B1XP90.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 32049.SYNPCC7002_A1694.

    PTM databases

    PhosSitei P13082028.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACA99683 ; ACA99683 ; SYNPCC7002_A1694 .
    GeneIDi 6057022.
    KEGGi syp:SYNPCC7002_A1694.
    PATRICi 23818014. VBISynSp37135_1949.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi YARYHRM.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci SSP32049:GKF7-1695-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of Synechococcus sp. PCC 7002."
      Li T., Zhao J., Zhao C., Liu Z., Zhao F., Marquardt J., Nomura C.T., Persson S., Detter J.C., Richardson P.M., Lanz C., Schuster S.C., Wang J., Li S., Huang X., Cai T., Yu Z., Luo J., Zhao J., Bryant D.A.
      Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 27264 / PCC 7002 / PR-6.

    Entry informationi

    Entry nameiSYL_SYNP2
    AccessioniPrimary (citable) accession number: B1XP90
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: May 20, 2008
    Last modified: October 1, 2014
    This is version 50 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3