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B1XP90 (SYL_SYNP2) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Leucine--tRNA ligase

EC=6.1.1.4
Alternative name(s):
Leucyl-tRNA synthetase
Short name=LeuRS
Gene names
Name:leuS
Ordered Locus Names:SYNPCC7002_A1694
OrganismSynechococcus sp. (strain ATCC 27264 / PCC 7002 / PR-6) (Agmenellum quadruplicatum) [Complete proteome] [HAMAP]
Taxonomic identifier32049 [NCBI]
Taxonomic lineageBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus

Protein attributes

Sequence length852 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu). HAMAP-Rule MF_00049

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00049.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processleucyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

aminoacyl-tRNA editing activity

Inferred from electronic annotation. Source: InterPro

leucine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 852852Leucine--tRNA ligase HAMAP-Rule MF_00049
PRO_1000091374

Regions

Motif42 – 5211"HIGH" region HAMAP-Rule MF_00049
Motif614 – 6185"KMSKS" region HAMAP-Rule MF_00049

Sites

Binding site6171ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
B1XP90 [UniParc].

Last modified May 20, 2008. Version 1.
Checksum: 0E88E0B0431A3D66

FASTA85295,642
        10         20         30         40         50         60 
METRYSAADI EAKWQQQWLE LGLDKTPSQS DKPKFYALSM FPYPSGKLHM GHVRNYVITD 

        70         80         90        100        110        120 
VIARYKRMQG YRVLHPMGWD AFGLPAENAA IDRGIPPAKW TYQNIAQMRE QLKQLGLSID 

       130        140        150        160        170        180 
WDREVATCSP DYYKWTQWLF LQFYKAGLAY QKEAAVNWDP IDQTVLANEQ VDAEGRSWRS 

       190        200        210        220        230        240 
GAIVEKKLLR QWFLKITDYA EELLQDLNTL DGWPERVKLM QENWIGKSTG AHLEFPVVGS 

       250        260        270        280        290        300 
DEKVAVFTTR LDTVFGVTYV VLAPEHPLVA QVTTPAQKAA VDAFIAEVSQ ESEQDRTADD 

       310        320        330        340        350        360 
KPKKGVATGG MVTNPFTGEE VPILIANYVL YEYGTGAVMG VPAHDSRDCK FAKENNLPIK 

       370        380        390        400        410        420 
MVIIPEGGDA TAVLTEAYTE AGIMVNSGQF DGLVSTEGKK AIAKFAAENG FGREQIQYRL 

       430        440        450        460        470        480 
RDWLISRQRY WGCPIPMIYC DDCGVVPVPD SDLPVVLPED VEFSARGGSP LAQMADWQAV 

       490        500        510        520        530        540 
DCPCCGKAAR RETDTMDTFI DSSWYFLRYT DANNTEKPFA LDPVNDWMAV DQYVGGIEHA 

       550        560        570        580        590        600 
ILHLLYSRFF TKVVRDRQLV SVDEPFKRLL TQGMVQALTY KNPRTNKYVP ADQVDPNDPK 

       610        620        630        640        650        660 
DPETGEPLTG FYEKMSKSKY NGVDPALVLD KYGADTARMF ILFKAPPEKD LEWDDADVEG 

       670        680        690        700        710        720 
QFRFLNRIWN LVAGYEAAET SVKATGELSK AEKDLRRAVH TAIKEIQEDL EGDYQFNTAI 

       730        740        750        760        770        780 
AELMKLNNAI KDVKCVDSPV YKEAIETLIL LLAPFAPHIA DELWSNLGHS ESIHTVPFPQ 

       790        800        810        820        830        840 
LDETALTVDE ITIVIQILGK TRGTIQVPAG ISKADLEKTA TASDIAQRYI AGKEIKKVIV 

       850 
VPNKLVNFVI PK 

« Hide

References

[1]"Complete sequence of Synechococcus sp. PCC 7002."
Li T., Zhao J., Zhao C., Liu Z., Zhao F., Marquardt J., Nomura C.T., Persson S., Detter J.C., Richardson P.M., Lanz C., Schuster S.C., Wang J., Li S., Huang X., Cai T., Yu Z., Luo J., Zhao J., Bryant D.A.
Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 27264 / PCC 7002 / PR-6.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000951 Genomic DNA. Translation: ACA99683.1.
RefSeqYP_001734939.1. NC_010475.1.

3D structure databases

ProteinModelPortalB1XP90.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING32049.SYNPCC7002_A1694.

PTM databases

PhosSiteP13082028.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACA99683; ACA99683; SYNPCC7002_A1694.
GeneID6057022.
KEGGsyp:SYNPCC7002_A1694.
PATRIC23818014. VBISynSp37135_1949.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0495.
HOGENOMHOG000200747.
KOK01869.
OMAGIEHACM.
OrthoDBEOG63Z74X.
ProtClustDBPRK00390.

Enzyme and pathway databases

BioCycSSP32049:GKF7-1695-MONOMER.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPMF_00049_B. Leu_tRNA_synth_B.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase_bac/mito.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSPR00985. TRNASYNTHLEU.
SUPFAMSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsTIGR00396. leuS_bact. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYL_SYNP2
AccessionPrimary (citable) accession number: B1XP90
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: May 20, 2008
Last modified: April 16, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries