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B1XP90

- SYL_SYNP2

UniProt

B1XP90 - SYL_SYNP2

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Synechococcus sp. (strain ATCC 27264 / PCC 7002 / PR-6) (Agmenellum quadruplicatum)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei617 – 6171ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSSP32049:GKF7-1695-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:SYNPCC7002_A1694
OrganismiSynechococcus sp. (strain ATCC 27264 / PCC 7002 / PR-6) (Agmenellum quadruplicatum)
Taxonomic identifieri32049 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
ProteomesiUP000001688: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 852852Leucine--tRNA ligasePRO_1000091374Add
BLAST

PTM databases

PhosSiteiP13082028.

Interactioni

Protein-protein interaction databases

STRINGi32049.SYNPCC7002_A1694.

Structurei

3D structure databases

ProteinModelPortaliB1XP90.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5211"HIGH" regionAdd
BLAST
Motifi614 – 6185"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiYARYHRM.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B1XP90-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
METRYSAADI EAKWQQQWLE LGLDKTPSQS DKPKFYALSM FPYPSGKLHM
60 70 80 90 100
GHVRNYVITD VIARYKRMQG YRVLHPMGWD AFGLPAENAA IDRGIPPAKW
110 120 130 140 150
TYQNIAQMRE QLKQLGLSID WDREVATCSP DYYKWTQWLF LQFYKAGLAY
160 170 180 190 200
QKEAAVNWDP IDQTVLANEQ VDAEGRSWRS GAIVEKKLLR QWFLKITDYA
210 220 230 240 250
EELLQDLNTL DGWPERVKLM QENWIGKSTG AHLEFPVVGS DEKVAVFTTR
260 270 280 290 300
LDTVFGVTYV VLAPEHPLVA QVTTPAQKAA VDAFIAEVSQ ESEQDRTADD
310 320 330 340 350
KPKKGVATGG MVTNPFTGEE VPILIANYVL YEYGTGAVMG VPAHDSRDCK
360 370 380 390 400
FAKENNLPIK MVIIPEGGDA TAVLTEAYTE AGIMVNSGQF DGLVSTEGKK
410 420 430 440 450
AIAKFAAENG FGREQIQYRL RDWLISRQRY WGCPIPMIYC DDCGVVPVPD
460 470 480 490 500
SDLPVVLPED VEFSARGGSP LAQMADWQAV DCPCCGKAAR RETDTMDTFI
510 520 530 540 550
DSSWYFLRYT DANNTEKPFA LDPVNDWMAV DQYVGGIEHA ILHLLYSRFF
560 570 580 590 600
TKVVRDRQLV SVDEPFKRLL TQGMVQALTY KNPRTNKYVP ADQVDPNDPK
610 620 630 640 650
DPETGEPLTG FYEKMSKSKY NGVDPALVLD KYGADTARMF ILFKAPPEKD
660 670 680 690 700
LEWDDADVEG QFRFLNRIWN LVAGYEAAET SVKATGELSK AEKDLRRAVH
710 720 730 740 750
TAIKEIQEDL EGDYQFNTAI AELMKLNNAI KDVKCVDSPV YKEAIETLIL
760 770 780 790 800
LLAPFAPHIA DELWSNLGHS ESIHTVPFPQ LDETALTVDE ITIVIQILGK
810 820 830 840 850
TRGTIQVPAG ISKADLEKTA TASDIAQRYI AGKEIKKVIV VPNKLVNFVI

PK
Length:852
Mass (Da):95,642
Last modified:May 20, 2008 - v1
Checksum:i0E88E0B0431A3D66
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000951 Genomic DNA. Translation: ACA99683.1.
RefSeqiWP_012307306.1. NC_010475.1.
YP_001734939.1. NC_010475.1.

Genome annotation databases

EnsemblBacteriaiACA99683; ACA99683; SYNPCC7002_A1694.
GeneIDi6057022.
KEGGisyp:SYNPCC7002_A1694.
PATRICi23818014. VBISynSp37135_1949.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000951 Genomic DNA. Translation: ACA99683.1 .
RefSeqi WP_012307306.1. NC_010475.1.
YP_001734939.1. NC_010475.1.

3D structure databases

ProteinModelPortali B1XP90.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 32049.SYNPCC7002_A1694.

PTM databases

PhosSitei P13082028.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACA99683 ; ACA99683 ; SYNPCC7002_A1694 .
GeneIDi 6057022.
KEGGi syp:SYNPCC7002_A1694.
PATRICi 23818014. VBISynSp37135_1949.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi YARYHRM.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci SSP32049:GKF7-1695-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of Synechococcus sp. PCC 7002."
    Li T., Zhao J., Zhao C., Liu Z., Zhao F., Marquardt J., Nomura C.T., Persson S., Detter J.C., Richardson P.M., Lanz C., Schuster S.C., Wang J., Li S., Huang X., Cai T., Yu Z., Luo J., Zhao J., Bryant D.A.
    Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 27264 / PCC 7002 / PR-6.

Entry informationi

Entry nameiSYL_SYNP2
AccessioniPrimary (citable) accession number: B1XP90
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: May 20, 2008
Last modified: October 29, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3