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Protein

N-(5'-phosphoribosyl)anthranilate isomerase

Gene

trpF

Organism
Synechococcus sp. (strain ATCC 27264 / PCC 7002 / PR-6) (Agmenellum quadruplicatum)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate.

Pathwayi: L-tryptophan biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes L-tryptophan from chorismate.
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Anthranilate synthase component 1 (trpE)
  2. Anthranilate phosphoribosyltransferase (trpD)
  3. N-(5'-phosphoribosyl)anthranilate isomerase (trpF)
  4. Indole-3-glycerol phosphate synthase (trpC)
  5. Tryptophan synthase alpha chain (trpA), Tryptophan synthase beta chain (trpB)
This subpathway is part of the pathway L-tryptophan biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-tryptophan from chorismate, the pathway L-tryptophan biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processAmino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00035; UER00042.

Names & Taxonomyi

Protein namesi
Recommended name:
N-(5'-phosphoribosyl)anthranilate isomerase (EC:5.3.1.24)
Short name:
PRAI
Gene namesi
Name:trpF
Ordered Locus Names:SYNPCC7002_A2854
OrganismiSynechococcus sp. (strain ATCC 27264 / PCC 7002 / PR-6) (Agmenellum quadruplicatum)
Taxonomic identifieri32049 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesSynechococcaceaeSynechococcus
Proteomesi
  • UP000001688 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000959441 – 216N-(5'-phosphoribosyl)anthranilate isomeraseAdd BLAST216

Interactioni

Protein-protein interaction databases

STRINGi32049.SYNPCC7002_A2854.

Structurei

3D structure databases

ProteinModelPortaliB1XNB2.
SMRiB1XNB2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TrpF family.

Phylogenomic databases

eggNOGiENOG4108ZGB. Bacteria.
COG0135. LUCA.
HOGENOMiHOG000161598.
KOiK01817.
OMAiFYAKSPR.
OrthoDBiPOG091H01PA.

Family and domain databases

CDDicd00405. PRAI. 1 hit.
Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00135. PRAI. 1 hit.
InterProiView protein in InterPro
IPR013785. Aldolase_TIM.
IPR001240. PRAI.
IPR011060. RibuloseP-bd_barrel.
PfamiView protein in Pfam
PF00697. PRAI. 1 hit.
SUPFAMiSSF51366. SSF51366. 1 hit.

Sequencei

Sequence statusi: Complete.

B1XNB2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRIKICGLTQ IDQAQAIAKV GVTDLGFICV QKSPRYVTPT QLATLTEALP
60 70 80 90 100
AHIGKVGVFA NQTLSEMLAI ISQGNLTTAQ LHGDESPELC QQLRQQRPDL
110 120 130 140 150
EIIKALRIRD RRSLEWAKQY ETVVDALLLD AYDPQQLGGT GHQINWDDLR
160 170 180 190 200
QFNPAVPWFL AGGLNPDNIA VALGQLHPDG IDLSSGVEQS PGIKDLSKVQ
210
ALMTALQAIA SQPLHA
Length:216
Mass (Da):23,517
Last modified:May 20, 2008 - v1
Checksum:i3FB768058C8F5E52
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000951 Genomic DNA. Translation: ACB00822.1.
RefSeqiWP_012308440.1. NC_010475.1.

Genome annotation databases

EnsemblBacteriaiACB00822; ACB00822; SYNPCC7002_A2854.
KEGGisyp:SYNPCC7002_A2854.

Similar proteinsi

Entry informationi

Entry nameiTRPF_SYNP2
AccessioniPrimary (citable) accession number: B1XNB2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: May 20, 2008
Last modified: October 25, 2017
This is version 54 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families