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Protein
Submitted name:

Succinate-semialdehyde dehydrogenase

Gene

SYNPCC7002_A2771

Organism
Synechococcus sp. (strain ATCC 27264 / PCC 7002 / PR-6) (Agmenellum quadruplicatum)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei139 – 1391NADPCombined sources
Binding sitei213 – 2131NADPCombined sources
Binding sitei262 – 2621NADPCombined sources

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi128 – 1314NADPCombined sources
Nucleotide bindingi154 – 1574NADPCombined sources
Nucleotide bindingi206 – 2072NADPCombined sources
Nucleotide bindingi228 – 2303NADPCombined sources
Nucleotide bindingi359 – 3613NADPCombined sources

GO - Molecular functioni

  1. nucleotide binding Source: UniProtKB-KW
  2. oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor Source: InterPro
Complete GO annotation...

Keywords - Ligandi

NADPCombined sources, Nucleotide-bindingCombined sources

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-17041.
SSP32049:GKF7-2772-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Succinate-semialdehyde dehydrogenaseImported
Gene namesi
Ordered Locus Names:SYNPCC7002_A2771Imported
OrganismiSynechococcus sp. (strain ATCC 27264 / PCC 7002 / PR-6) (Agmenellum quadruplicatum)Imported
Taxonomic identifieri32049 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
ProteomesiUP000001688: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi32049.SYNPCC7002_A2771.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3VZ1X-ray2.10A/B1-454[»]
3VZ2X-ray2.50A/B1-454[»]
3VZ3X-ray1.69A/B1-454[»]
4IT9X-ray1.70A/B1-454[»]
4ITAX-ray1.40A/B1-454[»]
4ITBX-ray1.40A/B1-454[»]
ProteinModelPortaliB1XMM6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

HOGENOMiHOG000271513.
KOiK00135.
OMAiEFTNAQT.
OrthoDBiEOG6BS8QW.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.

Sequencei

Sequence statusi: Complete.

B1XMM6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAIATINPTT GEICQRFKAL TPAEIDAKLA KAQEAFQAYR RTSFSQRRQW
60 70 80 90 100
LENAAAILER DTSKFAEIMT TEMGKTHQSA IAEAEKSALV CRYYAEHGEQ
110 120 130 140 150
FLANEYTETQ ATESYVCYQP LGILLAVMPW NFPFWQVFRF AAPALMAGNV
160 170 180 190 200
AVLKHASNVP QCALAVEAIL EAAGFPEGVF QTLLIGASQV EQVIKDPRVK
210 220 230 240 250
AATLTGSEPA GASLASLAGQ EIKPTLLELG GSDPFVVFPS ADLDEAVEVG
260 270 280 290 300
TVARTMNNGQ SCIAAKRFIL HEAIAAEFLE KLHLKFASLK IGDPMAPETD
310 320 330 340 350
IGPLATEGIL QDISRQVDQA VAAGAKILLG GRPLDRAGYF YPPTILTEIP
360 370 380 390 400
PGAKILQEEL FAPVAMVFTV KDLDQAIALA NDIPFGLGAS AWTNDPAEQQ
410 420 430 440 450
RFIQELDAGA VFINGMVKSD PRLPFGGTKR SGYGRELGLA GIRTFVNAKT

VWLK
Length:454
Mass (Da):49,019
Last modified:May 20, 2008 - v1
Checksum:i775446BD8C9D6CB6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000951 Genomic DNA. Translation: ACB00745.1.
RefSeqiWP_012308363.1. NC_010475.1.
YP_001736000.1. NC_010475.1.

Genome annotation databases

EnsemblBacteriaiACB00745; ACB00745; SYNPCC7002_A2771.
GeneIDi6056067.
KEGGisyp:SYNPCC7002_A2771.
PATRICi23820212. VBISynSp37135_3032.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000951 Genomic DNA. Translation: ACB00745.1.
RefSeqiWP_012308363.1. NC_010475.1.
YP_001736000.1. NC_010475.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3VZ1X-ray2.10A/B1-454[»]
3VZ2X-ray2.50A/B1-454[»]
3VZ3X-ray1.69A/B1-454[»]
4IT9X-ray1.70A/B1-454[»]
4ITAX-ray1.40A/B1-454[»]
4ITBX-ray1.40A/B1-454[»]
ProteinModelPortaliB1XMM6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi32049.SYNPCC7002_A2771.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACB00745; ACB00745; SYNPCC7002_A2771.
GeneIDi6056067.
KEGGisyp:SYNPCC7002_A2771.
PATRICi23820212. VBISynSp37135_3032.

Phylogenomic databases

HOGENOMiHOG000271513.
KOiK00135.
OMAiEFTNAQT.
OrthoDBiEOG6BS8QW.

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-17041.
SSP32049:GKF7-2772-MONOMER.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequence of Synechococcus sp. PCC 7002."
    Li T., Zhao J., Zhao C., Liu Z., Zhao F., Marquardt J., Nomura C.T., Persson S., Detter J.C., Richardson P.M., Lanz C., Schuster S.C., Wang J., Li S., Huang X., Cai T., Yu Z., Luo J., Zhao J., Bryant D.A.
    Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 27264 / PCC 7002 / PR-6Imported.
  2. "Structural basis for a cofactor-dependent oxidation protection and catalysis of cyanobacterial succinic semialdehyde dehydrogenase."
    Park J., Rhee S.
    J. Biol. Chem. 288:15760-15770(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.40 ANGSTROMS) IN COMPLEX WITH NADP.
  3. "Structural basis for cofactor and substrate selection by cyanobacterium succinic semialdehyde dehydrogenase."
    Yuan Z., Yin B., Wei D., Yuan Y.R.
    J. Struct. Biol. 182:125-135(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.69 ANGSTROMS) IN COMPLEX WITH NADP.

Entry informationi

Entry nameiB1XMM6_SYNP2
AccessioniPrimary (citable) accession number: B1XMM6
Entry historyi
Integrated into UniProtKB/TrEMBL: May 20, 2008
Last sequence update: May 20, 2008
Last modified: January 7, 2015
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.