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B1XL79 (HEMH_SYNP2) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 32. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ferrochelatase
EC=4.99.1.1
Alternative name(s):
Heme synthase
Protoheme ferro-lyase
Gene names
Name:hemH
Ordered Locus Names:SYNPCC7002_A2589
OrganismSynechococcus sp. (strain ATCC 27264 / PCC 7002 / PR-6) (Agmenellum quadruplicatum) [Complete proteome] [HAMAP]
Taxonomic identifier32049 [NCBI]
Taxonomic lineageBacteria › Cyanobacteria › Chroococcales › Synechococcus

Protein attributes

Sequence length386 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the ferrous insertion into protoporphyrin IX By similarity. HAMAP MF_00323

Catalytic activity

Protoheme + 2 H+ = protoporphyrin + Fe2+. HAMAP MF_00323

Pathway

Porphyrin metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1. HAMAP MF_00323

Subcellular location

Cytoplasm By similarity HAMAP MF_00323.

Sequence similarities

Belongs to the ferrochelatase family.

Ontologies

Keywords
   Biological processHeme biosynthesis
Porphyrin biosynthesis
   Cellular componentCytoplasm
   LigandIron
Metal-binding
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processheme biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionferrochelatase activity

Inferred from electronic annotation. Source: EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 386386Ferrochelatase HAMAP MF_00323
PRO_1000116087

Sites

Metal binding1961Iron By similarity
Metal binding2771Iron By similarity

Sequences

Sequence LengthMass (Da)Tools
B1XL79 [UniParc].

Last modified May 20, 2008. Version 1.
Checksum: 5AA821CC855DDB6B

FASTA38643,795
        10         20         30         40         50         60 
MGRVGVLLLN LGGPDKLEDV RPFLFNLFAD PEIIRLPAPW MQKPLAWLIS TLRAGKSQEN 

        70         80         90        100        110        120 
YKEIGGGSPL RQITEAQGTA LAQKLAEWGQ EVKVYVGMRY WHPFTEEAIA EIKKDDLDQL 

       130        140        150        160        170        180 
VVLPLYPQFS ISTSGSSFRV LEEMWRTDKD LNQLDYTLIP SWYDHPQYIA AMVDLIRQEL 

       190        200        210        220        230        240 
DQFDNPDQAH IFFSAHGVPQ SYVEEAGDPY QREIEECTKL IMEALGRPND YTLAYQSRVG 

       250        260        270        280        290        300 
PVEWLQPYTE DSLIALGEKG VKDLVVIPIS FVSEHIETLQ EIDIEYREVA EEAGIENFRR 

       310        320        330        340        350        360 
VPALNTHPLF IESLANLVTD SLEQCPRTFG QVTHPKENMK MYPQELSWGM NTSAEVLNGR 

       370        380 
LAMIGFLALL LELISGQGPL HFVGIM

« Hide

References

[1]"Complete sequence of Synechococcus sp. PCC 7002."
Li T., Zhao J., Zhao C., Liu Z., Zhao F., Marquardt J., Nomura C.T., Persson S., Detter J.C., Richardson P.M., Lanz C., Schuster S.C., Wang J., Li S., Huang X., Cai T., Yu Z., Luo J., Zhao J., Bryant D.A.
Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 27264 / PCC 7002 / PR-6.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000951 Genomic DNA. Translation: ACB00566.1.
RefSeqYP_001735821.1. NC_010475.1.

3D structure databases

ProteinModelPortalB1XL79.
ModBaseSearch...

Protein-protein interaction databases

STRINGB1XL79.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6056609.
GenomeReviewsGene locus SYNPCC7002_A2589 in contig CP000951_GR.
KEGGsyp:SYNPCC7002_A2589.
PATRIC23819840. VBISynSp37135_2849.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG697135.
OMALQKPLAW.
PhylomeDBB1XL79.
ProtClustDBPRK00035.

Family and domain databases

HAMAPMF_00323. Ferrochelatase.
[Tree]
InterProIPR023329. Chlorophyll_a/b-bd_dom.
IPR001015. Ferrochelatase.
IPR019772. Ferrochelatase_AS.
[Graphical view]
KOK01772.
PANTHERPTHR11108. Ferrochelatase. 1 hit.
PfamPF00762. Ferrochelatase. 1 hit.
[Graphical view]
SUPFAMSSF103511. SSF103511. 1 hit.
TIGRFAMsTIGR00109. HemH. 1 hit.
PROSITEPS00534. FERROCHELATASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHEMH_SYNP2
AccessionPrimary (citable) accession number: B1XL79
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: May 20, 2008
Last modified: January 25, 2012
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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