B1XKQ0 (DNAA_SYNP2) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Chromosomal replication initiator protein DnaA

Gene names

Name:	dnaA
Ordered Locus Names:	SYNPCC7002_A0001

Organism

Synechococcus sp. (strain ATCC 27264 / PCC 7002 / PR-6) (Agmenellum quadruplicatum) [Complete proteome] [HAMAP]

Taxonomic identifier

32049 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Chroococcales › Synechococcus

Protein attributes

Sequence length	449 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids By similarity. HAMAP MF_00377
Subcellular location	Cytoplasm By similarity HAMAP MF_00377.
Sequence similarities	Belongs to the DnaA family.

Ontologies

Keywords
Biological process	DNA replication
Cellular component	Cytoplasm
Ligand	ATP-binding DNA-binding Nucleotide-binding
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	DNA-dependent DNA replication initiation Inferred from electronic annotation. Source: InterPro regulation of DNA replication Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW DNA replication origin binding Inferred from electronic annotation. Source: InterPro nucleoside-triphosphatase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 449	449	Chromosomal replication initiator protein DnaA HAMAP MF_00377		PRO_1000122027
Regions
	Nucleotide binding	151 – 158	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	B1XKQ0 [UniParc]. Last modified May 20, 2008. Version 1. Checksum: 51FA0B32046B8D62	FASTA	449	50,517
	10 20 30 40 50 60 MTQNPQWLWQ EVLTKLEQQL SRPTYETWIQ PTAIQQWRED EIVLCAPNAF VLNHIQKYYG 70 80 90 100 110 120 ALITETIAEL LQQPVKVRLT SPEGNTLAAT QSFYSSRSGQ STRPGKKTPE LNSKYTFSRF 130 140 150 160 170 180 VVGPTNRMAH AAALAVAESP GRDFNPLVLC GGVGLGKTHL MQAIGHYRLD TQPDAKIFYV 190 200 210 220 230 240 STEQFTNDLI VAIRKDSLQT FREHYRTADI LLVDDIQFIE GKEYTQEEFF YTFNTLHEAG 250 260 270 280 290 300 KQIVLASDRP PHQIPGLQQR LSSRFSMGLI ADIQPPDLET RMAILQKKAE AENLNLSRSV 310 320 330 340 350 360 IEYIATHYTA NIRELEGALL RAVTHIAISG LPMTVENLAP ILNPTVEYAP AAPDVILQIA 370 380 390 400 410 420 AEATGVSIED LKGASRRREI STARQIAMYL MRQHTDLSLP RIGELFGGKD HTTVMYSCDK 430 440 IGQLLTKNQK ISQLVSQISD RINHHHQNL

References

[1]

"Complete sequence of Synechococcus sp. PCC 7002." Li T., Zhao J., Zhao C., Liu Z., Zhao F., Marquardt J., Nomura C.T., Persson S., Detter J.C., Richardson P.M., Lanz C., Schuster S.C., Wang J., Li S., Huang X., Cai T., Yu Z., Luo J., Zhao J., Bryant D.A. Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 27264 / PCC 7002 / PR-6.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000951 Genomic DNA. Translation: ACA98019.1.
RefSeq	YP_001733275.1. NC_010475.1.
3D structure databases
ProteinModelPortal	B1XKQ0.
ModBase	Search...
Protein-protein interaction databases
STRING	B1XKQ0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6055495.
GenomeReviews	Gene locus SYNPCC7002_A0001 in contig CP000951_GR.
KEGG	syp:SYNPCC7002_A0001.
PATRIC	23814406. VBISynSp37135_0171.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG695666.
OMA	CHTLNAL.
PhylomeDB	B1XKQ0.
ProtClustDB	PRK00149.
Family and domain databases
HAMAP	MF_00377. DnaA_bact. [Tree]
InterPro	IPR003593. ATPase_AAA+_core. IPR001957. Chromosome_initiator_DnaA. IPR020591. Chromosome_initiator_DnaA-like. IPR018312. Chromosome_initiator_DnaA_CS. IPR013159. DnaA_C. IPR013317. DnaA_Hda. IPR010921. Trp_repressor/repl_initiator. [Graphical view]
Gene3D	G3DSA:1.10.1750.10. DnaA_C. 1 hit.
KO	K02313.
Pfam	PF00308. Bac_DnaA. 1 hit. PF08299. Bac_DnaA_C. 1 hit. [Graphical view]
PRINTS	PR00051. DNAA.
SMART	SM00382. AAA. 1 hit. SM00760. Bac_DnaA_C. 1 hit. [Graphical view]
SUPFAM	SSF48295. Trp_repress_rep. 1 hit.
TIGRFAMs	TIGR00362. DnaA. 1 hit.
PROSITE	PS01008. DNAA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DNAA_SYNP2

Accession

Primary (citable) accession number: B1XKQ0

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	May 20, 2008
Last modified:	January 25, 2012
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program