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Protein

Catalase-peroxidase

Gene

katG

Organism
Synechococcus sp. (strain ATCC 27264 / PCC 7002 / PR-6) (Agmenellum quadruplicatum)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.UniRule annotation

Catalytic activityi

Donor + H2O2 = oxidized donor + 2 H2O.UniRule annotation
2 H2O2 = O2 + 2 H2O.UniRule annotation

Cofactori

heme bUniRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei96 – 961Transition state stabilizerUniRule annotation
Active sitei100 – 1001Proton acceptorUniRule annotation
Metal bindingi268 – 2681Iron (heme axial ligand)UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciSSP32049:GKF7-2423-MONOMER.

Protein family/group databases

PeroxiBasei6257. SspCP01_PCC7002.

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase-peroxidaseUniRule annotation (EC:1.11.1.21UniRule annotation)
Short name:
CPUniRule annotation
Alternative name(s):
Peroxidase/catalaseUniRule annotation
Gene namesi
Name:katGUniRule annotation
Ordered Locus Names:SYNPCC7002_A2422
OrganismiSynechococcus sp. (strain ATCC 27264 / PCC 7002 / PR-6) (Agmenellum quadruplicatum)
Taxonomic identifieri32049 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
Proteomesi
  • UP000001688 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 725725Catalase-peroxidasePRO_0000354942Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki99 ↔ 227Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-253)UniRule annotation
Cross-linki227 ↔ 253Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-99)UniRule annotation

Post-translational modificationi

The covalent Trp-Tyr-Met adduct is important for the catalase, but not the peroxidase activity of the enzyme.UniRule annotation

Proteomic databases

PRIDEiB1XK45.

Interactioni

Subunit structurei

Homodimer or homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi32049.SYNPCC7002_A2422.

Structurei

3D structure databases

ProteinModelPortaliB1XK45.
SMRiB1XK45. Positions 26-724.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Peroxidase/catalase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiTESKCPF.
OrthoDBiEOG6RRKKM.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B1XK45-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHDHITNTGG KCPVMHGALT TSSMATNMEW WPKALNLDIL HQHDHKTNPM
60 70 80 90 100
GANFNYQDAV KTLDVDALKR DLHALMTDSQ DWWPADWGHY GGLMIRMTWH
110 120 130 140 150
AAGTYRIADG RGGAGTGNQR FAPINSWPDN TNLDKARRLL WPLKKKYGNK
160 170 180 190 200
LSWADLIAYA GTIAYESMGL KTFGFAFGRE DIWHPEKDIY WGSEKEWLAP
210 220 230 240 250
SDNPHSRYSG ERDLENPLAA VMMGLIYVNP EGVDGNPDPL KTAHDIRITF
260 270 280 290 300
SRMAMNDEET VALTAGGHTV GKCHGNGDAT LLGPEPEAAD LDDQGLGWLN
310 320 330 340 350
KTQRGIGRNT VTSGIEGAWT TYPTQWDNGY FRLLLNYDWE LKKSPAGAWQ
360 370 380 390 400
WEPINIKEED KPVDVEDPSI RLSPIMTDAD MAMKMDPDYR QISERFYQDP
410 420 430 440 450
AYFAETFARA WFKLTHRDMG PKSRYIGPDV PQEDLLWQDP IPAGKTDYDP
460 470 480 490 500
QAVKDKIAAS GLSVSEMVCT AWDSARTFRG SDKRGGANGA RIRLAPQKDW
510 520 530 540 550
AGNEPARLAK VLPVLEAIAT ESGASVADVI VLAGNVGIEQ AAQAAGVEIT
560 570 580 590 600
VPFAPGRGDA TAEMTDVEGF AVLEPLHDGY RNWLQKDYVV SPEELMLDRT
610 620 630 640 650
QLMGLTAPEM TVLVGGMRVL GTNYGGTKHG VLTDREGALT NDFFVNLTDM
660 670 680 690 700
KYTWKPAGKN LYEIGDRHTG EVKWTATRVD LVFGCNSILR AYAEVYAQDD
710 720
SNEKFIQDFV AAWTKVMNAD RFDLA
Length:725
Mass (Da):80,606
Last modified:May 20, 2008 - v1
Checksum:i37FA7650DB77FF50
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000951 Genomic DNA. Translation: ACB00400.1.

Genome annotation databases

EnsemblBacteriaiACB00400; ACB00400; SYNPCC7002_A2422.
KEGGisyp:SYNPCC7002_A2422.
PATRICi23819486. VBISynSp37135_2673.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000951 Genomic DNA. Translation: ACB00400.1.

3D structure databases

ProteinModelPortaliB1XK45.
SMRiB1XK45. Positions 26-724.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi32049.SYNPCC7002_A2422.

Protein family/group databases

PeroxiBasei6257. SspCP01_PCC7002.

Proteomic databases

PRIDEiB1XK45.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACB00400; ACB00400; SYNPCC7002_A2422.
KEGGisyp:SYNPCC7002_A2422.
PATRICi23819486. VBISynSp37135_2673.

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiTESKCPF.
OrthoDBiEOG6RRKKM.

Enzyme and pathway databases

BioCyciSSP32049:GKF7-2423-MONOMER.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequence of Synechococcus sp. PCC 7002."
    Li T., Zhao J., Zhao C., Liu Z., Zhao F., Marquardt J., Nomura C.T., Persson S., Detter J.C., Richardson P.M., Lanz C., Schuster S.C., Wang J., Li S., Huang X., Cai T., Yu Z., Luo J., Zhao J., Bryant D.A.
    Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 27264 / PCC 7002 / PR-6.

Entry informationi

Entry nameiKATG_SYNP2
AccessioniPrimary (citable) accession number: B1XK45
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: May 20, 2008
Last modified: December 9, 2015
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.