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B1XJU0

- PNP_SYNP2

UniProt

B1XJU0 - PNP_SYNP2

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Protein
Polyribonucleotide nucleotidyltransferase
Gene
pnp, SYNPCC7002_A1066
Organism
Synechococcus sp. (strain ATCC 27264 / PCC 7002 / PR-6) (Agmenellum quadruplicatum)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction By similarity.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi496 – 4961Magnesium By similarity
Metal bindingi502 – 5021Magnesium By similarity

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. RNA binding Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP
  4. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. RNA processing Source: InterPro
  2. mRNA catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Enzyme and pathway databases

BioCyciSSP32049:GKF7-1066-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferase (EC:2.7.7.8)
Alternative name(s):
Polynucleotide phosphorylase
Short name:
PNPase
Gene namesi
Name:pnp
Ordered Locus Names:SYNPCC7002_A1066
OrganismiSynechococcus sp. (strain ATCC 27264 / PCC 7002 / PR-6) (Agmenellum quadruplicatum)
Taxonomic identifieri32049 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
ProteomesiUP000001688: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 714714Polyribonucleotide nucleotidyltransferaseUniRule annotation
PRO_1000192500Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi32049.SYNPCC7002_A1066.

Structurei

3D structure databases

ProteinModelPortaliB1XJU0.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini562 – 62160KH
Add
BLAST
Domaini631 – 69969S1 motif
Add
BLAST

Sequence similaritiesi

Contains 1 KH domain.
Contains 1 S1 motif domain.

Phylogenomic databases

eggNOGiCOG1185.
HOGENOMiHOG000218326.
KOiK00962.
OMAiGRMHIMD.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B1XJU0-1 [UniParc]FASTAAdd to Basket

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MQEHIQSISF DGREIRLKTG LFAPQAGGSV LIESGDTAVL VSATTAPGRQ    50
GIDFLPLLVD YEERLYAAGR IPGGYLRREG RPPERATLIS RLIDRPMRPL 100
FPQWLRDDIQ IVATTLSLDE EVPPDVLAVT GASVATLLAG LPFYGPMAAV 150
RVGLVGDDFI LNPTYREMMN GDLDLVVAGT PDGVIMVEAG ANQLPEADMI 200
EAIDFAYEAI QELIEAQRAL MKELGVEMVS AEPPAKDEEL EKFIGDRTTD 250
KIKKVLSQFD LDKNGRDAAL DEIKATEIIE AIEALPEDAP LRLKTTEEPK 300
LIDNTFKALT KKLMRSQIVE DGVRVDGRKL DQVRPISCRT AVLPRAVHGS 350
GLFNRGLTQV LSIATLGTPG DAQEMDDLHP SDEKRYLHHY NFPPYSVGET 400
RPMRSPGRRE IGHGALAERA LLPVLPPKDE FPYVIRVVSE VLSSNGSTSM 450
GSVCGSTLAL MDAGVPIAKP VSGAAMGLIK EGKEVRILTD IQGIEDFLGD 500
MDFKVAGTAD GITALQMDMK ITGLAVEVVA EAIKQALPAR LHILEKMTDV 550
IAEPKELSPA APRLLTIKID PDLIGMVIGP GGKTIKGITE QTRAKVDIAD 600
DGTVTIASSE SENAEKAKRL IVNMTRKLNE GDVYFGKVTR IIQIGAFVEI 650
MPGKEGMIHI SQLAEGRVGK VEDEVAVGDE VVVKVREIDN KGRINLTRLG 700
IHPDEAAAAR VAAQ 714
Length:714
Mass (Da):77,302
Last modified:May 20, 2008 - v1
Checksum:iB62608170DC3B7E1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000951 Genomic DNA. Translation: ACA99068.1.
RefSeqiWP_012306691.1. NC_010475.1.
YP_001734324.1. NC_010475.1.

Genome annotation databases

EnsemblBacteriaiACA99068; ACA99068; SYNPCC7002_A1066.
GeneIDi6056074.
KEGGisyp:SYNPCC7002_A1066.
PATRICi23816656. VBISynSp37135_1283.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000951 Genomic DNA. Translation: ACA99068.1 .
RefSeqi WP_012306691.1. NC_010475.1.
YP_001734324.1. NC_010475.1.

3D structure databases

ProteinModelPortali B1XJU0.
ModBasei Search...

Protein-protein interaction databases

STRINGi 32049.SYNPCC7002_A1066.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACA99068 ; ACA99068 ; SYNPCC7002_A1066 .
GeneIDi 6056074.
KEGGi syp:SYNPCC7002_A1066.
PATRICi 23816656. VBISynSp37135_1283.

Phylogenomic databases

eggNOGi COG1185.
HOGENOMi HOG000218326.
KOi K00962.
OMAi GRMHIMD.
OrthoDBi EOG6WT8CC.

Enzyme and pathway databases

BioCyci SSP32049:GKF7-1066-MONOMER.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005499. PNPase. 1 hit.
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of Synechococcus sp. PCC 7002."
    Li T., Zhao J., Zhao C., Liu Z., Zhao F., Marquardt J., Nomura C.T., Persson S., Detter J.C., Richardson P.M., Lanz C., Schuster S.C., Wang J., Li S., Huang X., Cai T., Yu Z., Luo J., Zhao J., Bryant D.A.
    Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 27264 / PCC 7002 / PR-6.

Entry informationi

Entry nameiPNP_SYNP2
AccessioniPrimary (citable) accession number: B1XJU0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: May 20, 2008
Last modified: September 3, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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