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B1XJU0

- PNP_SYNP2

UniProt

B1XJU0 - PNP_SYNP2

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Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Synechococcus sp. (strain ATCC 27264 / PCC 7002 / PR-6) (Agmenellum quadruplicatum)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Magnesium.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi496 – 4961MagnesiumUniRule annotation
Metal bindingi502 – 5021MagnesiumUniRule annotation

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
  4. RNA binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. mRNA catabolic process Source: UniProtKB-HAMAP
  2. RNA processing Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Enzyme and pathway databases

BioCyciSSP32049:GKF7-1066-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
Alternative name(s):
Polynucleotide phosphorylaseUniRule annotation
Short name:
PNPaseUniRule annotation
Gene namesi
Name:pnpUniRule annotation
Ordered Locus Names:SYNPCC7002_A1066
OrganismiSynechococcus sp. (strain ATCC 27264 / PCC 7002 / PR-6) (Agmenellum quadruplicatum)
Taxonomic identifieri32049 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
ProteomesiUP000001688: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 714714Polyribonucleotide nucleotidyltransferasePRO_1000192500Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi32049.SYNPCC7002_A1066.

Structurei

3D structure databases

ProteinModelPortaliB1XJU0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini562 – 62160KHUniRule annotationAdd
BLAST
Domaini631 – 69969S1 motifUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation
Contains 1 KH domain.UniRule annotation
Contains 1 S1 motif domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG1185.
HOGENOMiHOG000218326.
KOiK00962.
OMAiGRMHIMD.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B1XJU0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQEHIQSISF DGREIRLKTG LFAPQAGGSV LIESGDTAVL VSATTAPGRQ
60 70 80 90 100
GIDFLPLLVD YEERLYAAGR IPGGYLRREG RPPERATLIS RLIDRPMRPL
110 120 130 140 150
FPQWLRDDIQ IVATTLSLDE EVPPDVLAVT GASVATLLAG LPFYGPMAAV
160 170 180 190 200
RVGLVGDDFI LNPTYREMMN GDLDLVVAGT PDGVIMVEAG ANQLPEADMI
210 220 230 240 250
EAIDFAYEAI QELIEAQRAL MKELGVEMVS AEPPAKDEEL EKFIGDRTTD
260 270 280 290 300
KIKKVLSQFD LDKNGRDAAL DEIKATEIIE AIEALPEDAP LRLKTTEEPK
310 320 330 340 350
LIDNTFKALT KKLMRSQIVE DGVRVDGRKL DQVRPISCRT AVLPRAVHGS
360 370 380 390 400
GLFNRGLTQV LSIATLGTPG DAQEMDDLHP SDEKRYLHHY NFPPYSVGET
410 420 430 440 450
RPMRSPGRRE IGHGALAERA LLPVLPPKDE FPYVIRVVSE VLSSNGSTSM
460 470 480 490 500
GSVCGSTLAL MDAGVPIAKP VSGAAMGLIK EGKEVRILTD IQGIEDFLGD
510 520 530 540 550
MDFKVAGTAD GITALQMDMK ITGLAVEVVA EAIKQALPAR LHILEKMTDV
560 570 580 590 600
IAEPKELSPA APRLLTIKID PDLIGMVIGP GGKTIKGITE QTRAKVDIAD
610 620 630 640 650
DGTVTIASSE SENAEKAKRL IVNMTRKLNE GDVYFGKVTR IIQIGAFVEI
660 670 680 690 700
MPGKEGMIHI SQLAEGRVGK VEDEVAVGDE VVVKVREIDN KGRINLTRLG
710
IHPDEAAAAR VAAQ
Length:714
Mass (Da):77,302
Last modified:May 20, 2008 - v1
Checksum:iB62608170DC3B7E1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000951 Genomic DNA. Translation: ACA99068.1.
RefSeqiWP_012306691.1. NC_010475.1.
YP_001734324.1. NC_010475.1.

Genome annotation databases

EnsemblBacteriaiACA99068; ACA99068; SYNPCC7002_A1066.
GeneIDi6056074.
KEGGisyp:SYNPCC7002_A1066.
PATRICi23816656. VBISynSp37135_1283.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000951 Genomic DNA. Translation: ACA99068.1 .
RefSeqi WP_012306691.1. NC_010475.1.
YP_001734324.1. NC_010475.1.

3D structure databases

ProteinModelPortali B1XJU0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 32049.SYNPCC7002_A1066.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACA99068 ; ACA99068 ; SYNPCC7002_A1066 .
GeneIDi 6056074.
KEGGi syp:SYNPCC7002_A1066.
PATRICi 23816656. VBISynSp37135_1283.

Phylogenomic databases

eggNOGi COG1185.
HOGENOMi HOG000218326.
KOi K00962.
OMAi GRMHIMD.
OrthoDBi EOG6WT8CC.

Enzyme and pathway databases

BioCyci SSP32049:GKF7-1066-MONOMER.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005499. PNPase. 1 hit.
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of Synechococcus sp. PCC 7002."
    Li T., Zhao J., Zhao C., Liu Z., Zhao F., Marquardt J., Nomura C.T., Persson S., Detter J.C., Richardson P.M., Lanz C., Schuster S.C., Wang J., Li S., Huang X., Cai T., Yu Z., Luo J., Zhao J., Bryant D.A.
    Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 27264 / PCC 7002 / PR-6.

Entry informationi

Entry nameiPNP_SYNP2
AccessioniPrimary (citable) accession number: B1XJU0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: May 20, 2008
Last modified: October 29, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3