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Protein

NAD(P)H-quinone oxidoreductase chain 4 1

Gene

ndhD1

Organism
Synechococcus sp. (strain ATCC 27264 / PCC 7002 / PR-6) (Agmenellum quadruplicatum)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

NDH-1 shuttles electrons from NAD(P)H, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.UniRule annotation

Catalytic activityi

NAD(P)H + plastoquinone = NAD(P)+ + plastoquinol.UniRule annotation

GO - Molecular functioni

  1. NADH dehydrogenase (ubiquinone) activity Source: InterPro
  2. quinone binding Source: UniProtKB-KW

GO - Biological processi

  1. mitochondrial electron transport, NADH to ubiquinone Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD, NADP, Plastoquinone

Enzyme and pathway databases

BioCyciSSP32049:GKF7-1974-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD(P)H-quinone oxidoreductase chain 4 1UniRule annotation (EC:1.6.5.-UniRule annotation)
Alternative name(s):
NAD(P)H dehydrogenase I, chain 4 1UniRule annotation
NDH-1, chain 4 1UniRule annotation
Gene namesi
Name:ndhD1UniRule annotation
Ordered Locus Names:SYNPCC7002_A1973
OrganismiSynechococcus sp. (strain ATCC 27264 / PCC 7002 / PR-6) (Agmenellum quadruplicatum)
Taxonomic identifieri32049 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
ProteomesiUP000001688: Chromosome

Subcellular locationi

Cellular thylakoid membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei6 – 2621HelicalUniRule annotationAdd
BLAST
Transmembranei34 – 5421HelicalUniRule annotationAdd
BLAST
Transmembranei87 – 10721HelicalUniRule annotationAdd
BLAST
Transmembranei113 – 13321HelicalUniRule annotationAdd
BLAST
Transmembranei136 – 15621HelicalUniRule annotationAdd
BLAST
Transmembranei169 – 18921HelicalUniRule annotationAdd
BLAST
Transmembranei209 – 22921HelicalUniRule annotationAdd
BLAST
Transmembranei243 – 26321HelicalUniRule annotationAdd
BLAST
Transmembranei277 – 29721HelicalUniRule annotationAdd
BLAST
Transmembranei311 – 33121HelicalUniRule annotationAdd
BLAST
Transmembranei332 – 35221HelicalUniRule annotationAdd
BLAST
Transmembranei376 – 39621HelicalUniRule annotationAdd
BLAST
Transmembranei418 – 43821HelicalUniRule annotationAdd
BLAST
Transmembranei464 – 48421HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. thylakoid membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Thylakoid

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 534534NAD(P)H-quinone oxidoreductase chain 4 1PRO_0000343250Add
BLAST

Keywords - PTMi

Quinone

Interactioni

Protein-protein interaction databases

STRINGi32049.SYNPCC7002_A1973.

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I subunit 4 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1008.
HOGENOMiHOG000100683.
KOiK05575.
OMAiVTYERTH.
OrthoDBiEOG647TZ6.

Family and domain databases

HAMAPiMF_00491. NDH1_NuoM.
InterProiIPR022997. NADH_Q_OxRdtase_chain4.
IPR010227. NADH_Q_OxRdtase_chainM/4.
IPR001750. NADH_UbQ/plastoQ_OxRdtase.
IPR003918. NADH_UbQ_OxRdtase.
IPR000260. NADH_UbQ_OxRdtase_chain4_N.
[Graphical view]
PfamiPF00361. Oxidored_q1. 1 hit.
PF01059. Oxidored_q5_N. 1 hit.
[Graphical view]
PRINTSiPR01437. NUOXDRDTASE4.
TIGRFAMsiTIGR01972. NDH_I_M. 1 hit.

Sequencei

Sequence statusi: Complete.

B1XHP2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDSLQIPWLT TAIAFPLLAA LVIPLIPDKE GKTIRWYTLG VALTDFALLV
60 70 80 90 100
TAFWQNYDLG RTEFQLTENF AWIPQLGLNW SLGVDGLSMP LIILATLITT
110 120 130 140 150
LATLAAWNVT KKPKLFAGLI LVMLSAQIGV FAVQDLLLFF IMWELELVPV
160 170 180 190 200
YLLISIWGGK KRLYAATKFI LYTALGSVFI LASTLALAFY GGDVTFDMQA
210 220 230 240 250
LGLKDYPLAL ELLAYAGFLI GFGVKLPIFP LHTWLPDAHS EASAPVSMIL
260 270 280 290 300
AGVLLKMGGY GLIRLNMEML PDAHIRFAPL LIVLGIVNIV YGALTAFGQT
310 320 330 340 350
NLKRRLASSS ISHMGFVLVG IASFTDLGMN GAVLQMLSHG FIAAALFFLS
360 370 380 390 400
GVTYERTHTL MMDEMSGIAR LMPKTFAMFT AAAMASLALP GMSGFVSELT
410 420 430 440 450
VFLGLSNSDA YSYGFKAIAI FLTAVGVILT PIYLLSMLRE VFYGKGSQAP
460 470 480 490 500
LSLAAGEDAK PREIFVAVCL LAPIIAIGLY PKLATTTYDL KTVEVASKVR
510 520 530
AALPLYAEQL PQNGDRQAQM GLSSQMPALI APRF
Length:534
Mass (Da):57,894
Last modified:May 20, 2008 - v1
Checksum:i716A82E305785643
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000951 Genomic DNA. Translation: ACA99960.1.
RefSeqiWP_012307583.1. NC_010475.1.
YP_001735216.1. NC_010475.1.

Genome annotation databases

EnsemblBacteriaiACA99960; ACA99960; SYNPCC7002_A1973.
GeneIDi6055555.
KEGGisyp:SYNPCC7002_A1973.
PATRICi23818584. VBISynSp37135_2232.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000951 Genomic DNA. Translation: ACA99960.1.
RefSeqiWP_012307583.1. NC_010475.1.
YP_001735216.1. NC_010475.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi32049.SYNPCC7002_A1973.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACA99960; ACA99960; SYNPCC7002_A1973.
GeneIDi6055555.
KEGGisyp:SYNPCC7002_A1973.
PATRICi23818584. VBISynSp37135_2232.

Phylogenomic databases

eggNOGiCOG1008.
HOGENOMiHOG000100683.
KOiK05575.
OMAiVTYERTH.
OrthoDBiEOG647TZ6.

Enzyme and pathway databases

BioCyciSSP32049:GKF7-1974-MONOMER.

Family and domain databases

HAMAPiMF_00491. NDH1_NuoM.
InterProiIPR022997. NADH_Q_OxRdtase_chain4.
IPR010227. NADH_Q_OxRdtase_chainM/4.
IPR001750. NADH_UbQ/plastoQ_OxRdtase.
IPR003918. NADH_UbQ_OxRdtase.
IPR000260. NADH_UbQ_OxRdtase_chain4_N.
[Graphical view]
PfamiPF00361. Oxidored_q1. 1 hit.
PF01059. Oxidored_q5_N. 1 hit.
[Graphical view]
PRINTSiPR01437. NUOXDRDTASE4.
TIGRFAMsiTIGR01972. NDH_I_M. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete sequence of Synechococcus sp. PCC 7002."
    Li T., Zhao J., Zhao C., Liu Z., Zhao F., Marquardt J., Nomura C.T., Persson S., Detter J.C., Richardson P.M., Lanz C., Schuster S.C., Wang J., Li S., Huang X., Cai T., Yu Z., Luo J., Zhao J., Bryant D.A.
    Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 27264 / PCC 7002 / PR-6.

Entry informationi

Entry nameiNU4C1_SYNP2
AccessioniPrimary (citable) accession number: B1XHP2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: May 20, 2008
Last modified: January 7, 2015
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.