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B1XHP2 (NU4C1_SYNP2) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NAD(P)H-quinone oxidoreductase chain 4 1

EC=1.6.5.-
Alternative name(s):
NAD(P)H dehydrogenase I, chain 4 1
NDH-1, chain 4 1
Gene names
Name:ndhD1
Ordered Locus Names:SYNPCC7002_A1973
OrganismSynechococcus sp. (strain ATCC 27264 / PCC 7002 / PR-6) (Agmenellum quadruplicatum) [Complete proteome] [HAMAP]
Taxonomic identifier32049 [NCBI]
Taxonomic lineageBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus

Protein attributes

Sequence length534 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

NDH-1 shuttles electrons from NAD(P)H, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient By similarity. HAMAP-Rule MF_00491

Catalytic activity

NAD(P)H + plastoquinone = NAD(P)+ + plastoquinol. HAMAP-Rule MF_00491

Subcellular location

Cellular thylakoid membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_00491.

Sequence similarities

Belongs to the complex I subunit 4 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 534534NAD(P)H-quinone oxidoreductase chain 4 1 HAMAP-Rule MF_00491
PRO_0000343250

Regions

Transmembrane6 – 2621Helical; Potential
Transmembrane34 – 5421Helical; Potential
Transmembrane87 – 10721Helical; Potential
Transmembrane113 – 13321Helical; Potential
Transmembrane136 – 15621Helical; Potential
Transmembrane169 – 18921Helical; Potential
Transmembrane209 – 22921Helical; Potential
Transmembrane243 – 26321Helical; Potential
Transmembrane277 – 29721Helical; Potential
Transmembrane311 – 33121Helical; Potential
Transmembrane332 – 35221Helical; Potential
Transmembrane376 – 39621Helical; Potential
Transmembrane418 – 43821Helical; Potential
Transmembrane464 – 48421Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
B1XHP2 [UniParc].

Last modified May 20, 2008. Version 1.
Checksum: 716A82E305785643

FASTA53457,894
        10         20         30         40         50         60 
MDSLQIPWLT TAIAFPLLAA LVIPLIPDKE GKTIRWYTLG VALTDFALLV TAFWQNYDLG 

        70         80         90        100        110        120 
RTEFQLTENF AWIPQLGLNW SLGVDGLSMP LIILATLITT LATLAAWNVT KKPKLFAGLI 

       130        140        150        160        170        180 
LVMLSAQIGV FAVQDLLLFF IMWELELVPV YLLISIWGGK KRLYAATKFI LYTALGSVFI 

       190        200        210        220        230        240 
LASTLALAFY GGDVTFDMQA LGLKDYPLAL ELLAYAGFLI GFGVKLPIFP LHTWLPDAHS 

       250        260        270        280        290        300 
EASAPVSMIL AGVLLKMGGY GLIRLNMEML PDAHIRFAPL LIVLGIVNIV YGALTAFGQT 

       310        320        330        340        350        360 
NLKRRLASSS ISHMGFVLVG IASFTDLGMN GAVLQMLSHG FIAAALFFLS GVTYERTHTL 

       370        380        390        400        410        420 
MMDEMSGIAR LMPKTFAMFT AAAMASLALP GMSGFVSELT VFLGLSNSDA YSYGFKAIAI 

       430        440        450        460        470        480 
FLTAVGVILT PIYLLSMLRE VFYGKGSQAP LSLAAGEDAK PREIFVAVCL LAPIIAIGLY 

       490        500        510        520        530 
PKLATTTYDL KTVEVASKVR AALPLYAEQL PQNGDRQAQM GLSSQMPALI APRF 

« Hide

References

[1]"Complete sequence of Synechococcus sp. PCC 7002."
Li T., Zhao J., Zhao C., Liu Z., Zhao F., Marquardt J., Nomura C.T., Persson S., Detter J.C., Richardson P.M., Lanz C., Schuster S.C., Wang J., Li S., Huang X., Cai T., Yu Z., Luo J., Zhao J., Bryant D.A.
Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 27264 / PCC 7002 / PR-6.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000951 Genomic DNA. Translation: ACA99960.1.
RefSeqYP_001735216.1. NC_010475.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING32049.SYNPCC7002_A1973.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACA99960; ACA99960; SYNPCC7002_A1973.
GeneID6055555.
KEGGsyp:SYNPCC7002_A1973.
PATRIC23818584. VBISynSp37135_2232.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1008.
HOGENOMHOG000100683.
KOK05575.
OMALINAWIT.
OrthoDBEOG647TZ6.

Enzyme and pathway databases

BioCycSSP32049:GKF7-1974-MONOMER.

Family and domain databases

HAMAPMF_00491. NDH1_NuoM.
InterProIPR022997. NADH_Q_OxRdtase_chain4.
IPR010227. NADH_Q_OxRdtase_chainM/4.
IPR001750. NADH_UbQ/plastoQ_OxRdtase.
IPR003918. NADH_UbQ_OxRdtase.
IPR000260. NADH_UbQ_OxRdtase_chain4_N.
[Graphical view]
PfamPF00361. Oxidored_q1. 1 hit.
PF01059. Oxidored_q5_N. 1 hit.
[Graphical view]
PRINTSPR01437. NUOXDRDTASE4.
TIGRFAMsTIGR01972. NDH_I_M. 1 hit.
ProtoNetSearch...

Entry information

Entry nameNU4C1_SYNP2
AccessionPrimary (citable) accession number: B1XHP2
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: May 20, 2008
Last modified: May 14, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families