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B1XHP2

- NU4C1_SYNP2

UniProt

B1XHP2 - NU4C1_SYNP2

Protein

NAD(P)H-quinone oxidoreductase chain 4 1

Gene

ndhD1

Organism
Synechococcus sp. (strain ATCC 27264 / PCC 7002 / PR-6) (Agmenellum quadruplicatum)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 45 (01 Oct 2014)
      Sequence version 1 (20 May 2008)
      Previous versions | rss
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    Functioni

    NDH-1 shuttles electrons from NAD(P)H, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.UniRule annotation

    Catalytic activityi

    NAD(P)H + plastoquinone = NAD(P)+ + plastoquinol.UniRule annotation

    GO - Molecular functioni

    1. NADH dehydrogenase (ubiquinone) activity Source: InterPro
    2. quinone binding Source: UniProtKB-KW

    GO - Biological processi

    1. mitochondrial electron transport, NADH to ubiquinone Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NAD, NADP, Plastoquinone

    Enzyme and pathway databases

    BioCyciSSP32049:GKF7-1974-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NAD(P)H-quinone oxidoreductase chain 4 1UniRule annotation (EC:1.6.5.-UniRule annotation)
    Alternative name(s):
    NAD(P)H dehydrogenase I, chain 4 1UniRule annotation
    NDH-1, chain 4 1UniRule annotation
    Gene namesi
    Name:ndhD1UniRule annotation
    Ordered Locus Names:SYNPCC7002_A1973
    OrganismiSynechococcus sp. (strain ATCC 27264 / PCC 7002 / PR-6) (Agmenellum quadruplicatum)
    Taxonomic identifieri32049 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
    ProteomesiUP000001688: Chromosome

    Subcellular locationi

    Cellular thylakoid membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. thylakoid membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Thylakoid

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 534534NAD(P)H-quinone oxidoreductase chain 4 1PRO_0000343250Add
    BLAST

    Keywords - PTMi

    Quinone

    Interactioni

    Protein-protein interaction databases

    STRINGi32049.SYNPCC7002_A1973.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei6 – 2621HelicalUniRule annotationAdd
    BLAST
    Transmembranei34 – 5421HelicalUniRule annotationAdd
    BLAST
    Transmembranei87 – 10721HelicalUniRule annotationAdd
    BLAST
    Transmembranei113 – 13321HelicalUniRule annotationAdd
    BLAST
    Transmembranei136 – 15621HelicalUniRule annotationAdd
    BLAST
    Transmembranei169 – 18921HelicalUniRule annotationAdd
    BLAST
    Transmembranei209 – 22921HelicalUniRule annotationAdd
    BLAST
    Transmembranei243 – 26321HelicalUniRule annotationAdd
    BLAST
    Transmembranei277 – 29721HelicalUniRule annotationAdd
    BLAST
    Transmembranei311 – 33121HelicalUniRule annotationAdd
    BLAST
    Transmembranei332 – 35221HelicalUniRule annotationAdd
    BLAST
    Transmembranei376 – 39621HelicalUniRule annotationAdd
    BLAST
    Transmembranei418 – 43821HelicalUniRule annotationAdd
    BLAST
    Transmembranei464 – 48421HelicalUniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the complex I subunit 4 family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1008.
    HOGENOMiHOG000100683.
    KOiK05575.
    OMAiLINAWIT.
    OrthoDBiEOG647TZ6.

    Family and domain databases

    HAMAPiMF_00491. NDH1_NuoM.
    InterProiIPR022997. NADH_Q_OxRdtase_chain4.
    IPR010227. NADH_Q_OxRdtase_chainM/4.
    IPR001750. NADH_UbQ/plastoQ_OxRdtase.
    IPR003918. NADH_UbQ_OxRdtase.
    IPR000260. NADH_UbQ_OxRdtase_chain4_N.
    [Graphical view]
    PfamiPF00361. Oxidored_q1. 1 hit.
    PF01059. Oxidored_q5_N. 1 hit.
    [Graphical view]
    PRINTSiPR01437. NUOXDRDTASE4.
    TIGRFAMsiTIGR01972. NDH_I_M. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B1XHP2-1 [UniParc]FASTAAdd to Basket

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    MDSLQIPWLT TAIAFPLLAA LVIPLIPDKE GKTIRWYTLG VALTDFALLV    50
    TAFWQNYDLG RTEFQLTENF AWIPQLGLNW SLGVDGLSMP LIILATLITT 100
    LATLAAWNVT KKPKLFAGLI LVMLSAQIGV FAVQDLLLFF IMWELELVPV 150
    YLLISIWGGK KRLYAATKFI LYTALGSVFI LASTLALAFY GGDVTFDMQA 200
    LGLKDYPLAL ELLAYAGFLI GFGVKLPIFP LHTWLPDAHS EASAPVSMIL 250
    AGVLLKMGGY GLIRLNMEML PDAHIRFAPL LIVLGIVNIV YGALTAFGQT 300
    NLKRRLASSS ISHMGFVLVG IASFTDLGMN GAVLQMLSHG FIAAALFFLS 350
    GVTYERTHTL MMDEMSGIAR LMPKTFAMFT AAAMASLALP GMSGFVSELT 400
    VFLGLSNSDA YSYGFKAIAI FLTAVGVILT PIYLLSMLRE VFYGKGSQAP 450
    LSLAAGEDAK PREIFVAVCL LAPIIAIGLY PKLATTTYDL KTVEVASKVR 500
    AALPLYAEQL PQNGDRQAQM GLSSQMPALI APRF 534
    Length:534
    Mass (Da):57,894
    Last modified:May 20, 2008 - v1
    Checksum:i716A82E305785643
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000951 Genomic DNA. Translation: ACA99960.1.
    RefSeqiWP_012307583.1. NC_010475.1.
    YP_001735216.1. NC_010475.1.

    Genome annotation databases

    EnsemblBacteriaiACA99960; ACA99960; SYNPCC7002_A1973.
    GeneIDi6055555.
    KEGGisyp:SYNPCC7002_A1973.
    PATRICi23818584. VBISynSp37135_2232.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000951 Genomic DNA. Translation: ACA99960.1 .
    RefSeqi WP_012307583.1. NC_010475.1.
    YP_001735216.1. NC_010475.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 32049.SYNPCC7002_A1973.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACA99960 ; ACA99960 ; SYNPCC7002_A1973 .
    GeneIDi 6055555.
    KEGGi syp:SYNPCC7002_A1973.
    PATRICi 23818584. VBISynSp37135_2232.

    Phylogenomic databases

    eggNOGi COG1008.
    HOGENOMi HOG000100683.
    KOi K05575.
    OMAi LINAWIT.
    OrthoDBi EOG647TZ6.

    Enzyme and pathway databases

    BioCyci SSP32049:GKF7-1974-MONOMER.

    Family and domain databases

    HAMAPi MF_00491. NDH1_NuoM.
    InterProi IPR022997. NADH_Q_OxRdtase_chain4.
    IPR010227. NADH_Q_OxRdtase_chainM/4.
    IPR001750. NADH_UbQ/plastoQ_OxRdtase.
    IPR003918. NADH_UbQ_OxRdtase.
    IPR000260. NADH_UbQ_OxRdtase_chain4_N.
    [Graphical view ]
    Pfami PF00361. Oxidored_q1. 1 hit.
    PF01059. Oxidored_q5_N. 1 hit.
    [Graphical view ]
    PRINTSi PR01437. NUOXDRDTASE4.
    TIGRFAMsi TIGR01972. NDH_I_M. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of Synechococcus sp. PCC 7002."
      Li T., Zhao J., Zhao C., Liu Z., Zhao F., Marquardt J., Nomura C.T., Persson S., Detter J.C., Richardson P.M., Lanz C., Schuster S.C., Wang J., Li S., Huang X., Cai T., Yu Z., Luo J., Zhao J., Bryant D.A.
      Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 27264 / PCC 7002 / PR-6.

    Entry informationi

    Entry nameiNU4C1_SYNP2
    AccessioniPrimary (citable) accession number: B1XHP2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 2008
    Last sequence update: May 20, 2008
    Last modified: October 1, 2014
    This is version 45 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3