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Protein
Submitted name:

Ureidoglycolate dehydrogenase

Gene

allD

Organism
Escherichia coli (strain K12 / DH10B)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei44 – 441NADCombined sources
Binding sitei140 – 1401NADCombined sources
Binding sitei158 – 1581NADCombined sources
Binding sitei224 – 2241NADCombined sources

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi116 – 1183NADCombined sources
Nucleotide bindingi174 – 1763NADCombined sources
Nucleotide bindingi306 – 3083NADCombined sources

GO - Molecular functioni

  1. nucleotide binding Source: UniProtKB-KW
  2. oxidoreductase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseSAAS annotation

Keywords - Ligandi

NADCombined sources, Nucleotide-bindingCombined sources

Enzyme and pathway databases

BioCyciECOL316385:GJ8B-463-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Ureidoglycolate dehydrogenaseImported
Gene namesi
Name:allDImported
Ordered Locus Names:ECDH10B_0473Imported
OrganismiEscherichia coli (strain K12 / DH10B)Imported
Taxonomic identifieri316385 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000001689: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi316385.ECDH10B_0473.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4FJSX-ray2.13A/B1-349[»]
4FJUX-ray1.77A/B1-349[»]
ProteinModelPortaliB1XGB5.
SMRiB1XGB5. Positions 1-337.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiCOG2055.
HOGENOMiHOG000173270.
KOiK00073.
OMAiFGKHVSS.
OrthoDBiEOG6ZPSZJ.

Family and domain databases

InterProiIPR003767. Malate/L-lactate_DH.
IPR017590. Ureidoglycolate_dehydrogenase.
[Graphical view]
PANTHERiPTHR11091. PTHR11091. 1 hit.
PfamiPF02615. Ldh_2. 1 hit.
[Graphical view]
SUPFAMiSSF89733. SSF89733. 1 hit.
TIGRFAMsiTIGR03175. AllD. 1 hit.

Sequencei

Sequence statusi: Complete.

B1XGB5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKISRETLHQ LIENKLCQAG LKREHAATVA EVLVYADARG IHSHGAVRVE
60 70 80 90 100
YYAERISKGG TNREPEFRLE ETGPCSAILH ADNAAGQVAA KMGMEHAIKT
110 120 130 140 150
AQQNGVAVVG ISRMGHSGAI SYFVQQAARA GFIGISMCQS DPMVVPFGGA
160 170 180 190 200
EIYYGTNPLA FAAPGEGDEI LTFDMATTVQ AWGKVLDARS RNMSIPDTWA
210 220 230 240 250
VDKNGVPTTD PFAVHALLPA AGPKGYGLMM MIDVLSGVLL GLPFGRQVSS
260 270 280 290 300
MYDDLHAGRN LGQLHIVINP NFFSSSELFR QHLSQTMREL NAITPAPGFN
310 320 330 340
QVYYPGQDQD IKQRKAAVEG IEIVDDIYQY LISDALYNTS YETKNPFAQ
Length:349
Mass (Da):37,967
Last modified:May 20, 2008 - v1
Checksum:i93C3076A66141C4E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000948 Genomic DNA. Translation: ACB01642.1.
RefSeqiYP_001729420.1. NC_010473.1.

Genome annotation databases

EnsemblBacteriaiACB01642; ACB01642; ECDH10B_0473.
GeneIDi6059947.
KEGGiecd:ECDH10B_0473.
PATRICi18460722. VBIEscCol59506_0479.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000948 Genomic DNA. Translation: ACB01642.1.
RefSeqiYP_001729420.1. NC_010473.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4FJSX-ray2.13A/B1-349[»]
4FJUX-ray1.77A/B1-349[»]
ProteinModelPortaliB1XGB5.
SMRiB1XGB5. Positions 1-337.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi316385.ECDH10B_0473.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACB01642; ACB01642; ECDH10B_0473.
GeneIDi6059947.
KEGGiecd:ECDH10B_0473.
PATRICi18460722. VBIEscCol59506_0479.

Phylogenomic databases

eggNOGiCOG2055.
HOGENOMiHOG000173270.
KOiK00073.
OMAiFGKHVSS.
OrthoDBiEOG6ZPSZJ.

Enzyme and pathway databases

BioCyciECOL316385:GJ8B-463-MONOMER.

Family and domain databases

InterProiIPR003767. Malate/L-lactate_DH.
IPR017590. Ureidoglycolate_dehydrogenase.
[Graphical view]
PANTHERiPTHR11091. PTHR11091. 1 hit.
PfamiPF02615. Ldh_2. 1 hit.
[Graphical view]
SUPFAMiSSF89733. SSF89733. 1 hit.
TIGRFAMsiTIGR03175. AllD. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The complete genome sequence of Escherichia coli DH10B: insights into the biology of a laboratory workhorse."
    Durfee T., Nelson R., Baldwin S., Plunkett G. III, Burland V., Mau B., Petrosino J.F., Qin X., Muzny D.M., Ayele M., Gibbs R.A., Csorgo B., Posfai G., Weinstock G.M., Blattner F.R.
    J. Bacteriol. 190:2597-2606(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / DH10BImported.
  2. "Structural and functional insights into (S)-ureidoglycolate dehydrogenase, a metabolic branch point enzyme in nitrogen utilization."
    Kim M.I., Shin I., Cho S., Lee J., Rhee S.
    PLoS ONE 7:e52066-e52066(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.77 ANGSTROMS) IN COMPLEX WITH NAD.

Entry informationi

Entry nameiB1XGB5_ECODH
AccessioniPrimary (citable) accession number: B1XGB5
Entry historyi
Integrated into UniProtKB/TrEMBL: May 20, 2008
Last sequence update: May 20, 2008
Last modified: January 7, 2015
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.