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B1XEJ9

- RPIA_ECODH

UniProt

B1XEJ9 - RPIA_ECODH

Protein

Ribose-5-phosphate isomerase A

Gene

rpiA

Organism
Escherichia coli (strain K12 / DH10B)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 40 (01 Oct 2014)
      Sequence version 1 (20 May 2008)
      Previous versions | rss
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    Functioni

    Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.UniRule annotation

    Catalytic activityi

    D-ribose 5-phosphate = D-ribulose 5-phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei103 – 1031Proton acceptorUniRule annotation
    Binding sitei121 – 1211SubstrateUniRule annotation

    GO - Molecular functioni

    1. ribose-5-phosphate isomerase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. pentose-phosphate shunt, non-oxidative branch Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Isomerase

    Enzyme and pathway databases

    BioCyciECOL316385:GJ8B-2963-MONOMER.
    UniPathwayiUPA00115; UER00412.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribose-5-phosphate isomerase AUniRule annotation (EC:5.3.1.6UniRule annotation)
    Alternative name(s):
    Phosphoriboisomerase AUniRule annotation
    Short name:
    PRIUniRule annotation
    Gene namesi
    Name:rpiAUniRule annotation
    Ordered Locus Names:ECDH10B_3089
    OrganismiEscherichia coli (strain K12 / DH10B)
    Taxonomic identifieri316385 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000001689: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 219219Ribose-5-phosphate isomerase APRO_1000097661Add
    BLAST

    Proteomic databases

    PRIDEiB1XEJ9.

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi316385.ECDH10B_3089.

    Structurei

    3D structure databases

    ProteinModelPortaliB1XEJ9.
    SMRiB1XEJ9. Positions 2-219.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni28 – 314Substrate bindingUniRule annotation
    Regioni81 – 844Substrate bindingUniRule annotation
    Regioni94 – 974Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the ribose 5-phosphate isomerase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0120.
    HOGENOMiHOG000276368.
    KOiK01807.
    OMAiMDQLEMK.
    OrthoDBiEOG67MF61.

    Family and domain databases

    HAMAPiMF_00170. Rib_5P_isom_A.
    InterProiIPR004788. Ribose5P_isomerase_typA.
    IPR020672. Ribose5P_isomerase_typA_subgr.
    [Graphical view]
    PANTHERiPTHR11934. PTHR11934. 1 hit.
    PfamiPF06026. Rib_5-P_isom_A. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00021. rpiA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B1XEJ9-1 [UniParc]FASTAAdd to Basket

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    MTQDELKKAV GWAALQYVQP GTIVGVGTGS TAAHFIDALG TMKGQIEGAV    50
    SSSDASTEKL KSLGIHVFDL NEVDSLGIYV DGADEINGHM QMIKGGGAAL 100
    TREKIIASVA EKFICIADAS KQVDILGKFP LPVEVIPMAR SAVARQLVKL 150
    GGRPEYRQGV VTDNGNVILD VHGMEILDPI AMENAINAIP GVVTVGLFAN 200
    RGADVALIGT PDGVKTIVK 219
    Length:219
    Mass (Da):22,860
    Last modified:May 20, 2008 - v1
    Checksum:iB53C49CC3DB188BC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000948 Genomic DNA. Translation: ACB04015.1.
    RefSeqiYP_001731793.1. NC_010473.1.

    Genome annotation databases

    EnsemblBacteriaiACB04015; ACB04015; ECDH10B_3089.
    GeneIDi6060133.
    KEGGiecd:ECDH10B_3089.
    PATRICi18466085. VBIEscCol59506_3107.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000948 Genomic DNA. Translation: ACB04015.1 .
    RefSeqi YP_001731793.1. NC_010473.1.

    3D structure databases

    ProteinModelPortali B1XEJ9.
    SMRi B1XEJ9. Positions 2-219.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 316385.ECDH10B_3089.

    Proteomic databases

    PRIDEi B1XEJ9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACB04015 ; ACB04015 ; ECDH10B_3089 .
    GeneIDi 6060133.
    KEGGi ecd:ECDH10B_3089.
    PATRICi 18466085. VBIEscCol59506_3107.

    Phylogenomic databases

    eggNOGi COG0120.
    HOGENOMi HOG000276368.
    KOi K01807.
    OMAi MDQLEMK.
    OrthoDBi EOG67MF61.

    Enzyme and pathway databases

    UniPathwayi UPA00115 ; UER00412 .
    BioCyci ECOL316385:GJ8B-2963-MONOMER.

    Family and domain databases

    HAMAPi MF_00170. Rib_5P_isom_A.
    InterProi IPR004788. Ribose5P_isomerase_typA.
    IPR020672. Ribose5P_isomerase_typA_subgr.
    [Graphical view ]
    PANTHERi PTHR11934. PTHR11934. 1 hit.
    Pfami PF06026. Rib_5-P_isom_A. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00021. rpiA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The complete genome sequence of Escherichia coli DH10B: insights into the biology of a laboratory workhorse."
      Durfee T., Nelson R., Baldwin S., Plunkett G. III, Burland V., Mau B., Petrosino J.F., Qin X., Muzny D.M., Ayele M., Gibbs R.A., Csorgo B., Posfai G., Weinstock G.M., Blattner F.R.
      J. Bacteriol. 190:2597-2606(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / DH10B.

    Entry informationi

    Entry nameiRPIA_ECODH
    AccessioniPrimary (citable) accession number: B1XEJ9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: May 20, 2008
    Last modified: October 1, 2014
    This is version 40 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3