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B1XC50

- APAH_ECODH

UniProt

B1XC50 - APAH_ECODH

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Protein
Bis(5'-nucleosyl)-tetraphosphatase, symmetrical
Gene
apaH, ECDH10B_0050
Organism
Escherichia coli (strain K12 / DH10B)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP By similarity.UniRule annotation

Catalytic activityi

P1,P(4)-bis(5'-adenosyl) tetraphosphate + H2O = 2 ADP.UniRule annotation

GO - Molecular functioni

  1. bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciECOL316385:GJ8B-50-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Bis(5'-nucleosyl)-tetraphosphatase, symmetrical (EC:3.6.1.41)
Alternative name(s):
Ap4A hydrolase
Diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase
Diadenosine tetraphosphatase
Gene namesi
Name:apaH
Ordered Locus Names:ECDH10B_0050
OrganismiEscherichia coli (strain K12 / DH10B)
Taxonomic identifieri316385 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000001689: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 280280Bis(5'-nucleosyl)-tetraphosphatase, symmetricalUniRule annotation
PRO_1000099323Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi316385.ECDH10B_0050.

Structurei

3D structure databases

ProteinModelPortaliB1XC50.
SMRiB1XC50. Positions 2-268.

Family & Domainsi

Sequence similaritiesi

Belongs to the Ap4A hydrolase family.

Phylogenomic databases

eggNOGiCOG0639.
HOGENOMiHOG000251871.
KOiK01525.
OMAiINAFTRM.
OrthoDBiEOG66B3WP.

Family and domain databases

Gene3Di3.60.21.10. 2 hits.
HAMAPiMF_00199. ApaH.
InterProiIPR004617. ApaH.
IPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PIRSFiPIRSF000903. B5n-ttraPtase_sm. 1 hit.
SUPFAMiSSF56300. SSF56300. 1 hit.
TIGRFAMsiTIGR00668. apaH. 1 hit.

Sequencei

Sequence statusi: Complete.

B1XC50-1 [UniParc]FASTAAdd to Basket

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MATYLIGDVH GCYDELIALL HKVEFTPGKD TLWLTGDLVA RGPGSLDVLR    50
YVKSLGDSVR LVLGNHDLHL LAVFAGISRN KPKDRLTPLL EAPDADELLN 100
WLRRQPLLQI DEEKKLVMAH AGITPQWDLQ TAKECARDVE AVLSSDSYPF 150
FLDAMYGDMP NNWSPELRGL GRLRFITNAF TRMRFCFPNG QLDMYSKESP 200
EEAPAPLKPW FAIPGPVAEE YSIAFGHWAS LEGKGTPEGI YALDTGCCWG 250
GTLTCLRWED KQYFVQPSNR HKDLGEAAAS 280
Length:280
Mass (Da):31,297
Last modified:May 20, 2008 - v1
Checksum:iBD6560C73446C1BB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000948 Genomic DNA. Translation: ACB01254.1.
RefSeqiYP_001729032.1. NC_010473.1.

Genome annotation databases

EnsemblBacteriaiACB01254; ACB01254; ECDH10B_0050.
GeneIDi6060780.
KEGGiecd:ECDH10B_0050.
PATRICi18459848. VBIEscCol59506_0051.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000948 Genomic DNA. Translation: ACB01254.1 .
RefSeqi YP_001729032.1. NC_010473.1.

3D structure databases

ProteinModelPortali B1XC50.
SMRi B1XC50. Positions 2-268.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 316385.ECDH10B_0050.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACB01254 ; ACB01254 ; ECDH10B_0050 .
GeneIDi 6060780.
KEGGi ecd:ECDH10B_0050.
PATRICi 18459848. VBIEscCol59506_0051.

Phylogenomic databases

eggNOGi COG0639.
HOGENOMi HOG000251871.
KOi K01525.
OMAi INAFTRM.
OrthoDBi EOG66B3WP.

Enzyme and pathway databases

BioCyci ECOL316385:GJ8B-50-MONOMER.

Family and domain databases

Gene3Di 3.60.21.10. 2 hits.
HAMAPi MF_00199. ApaH.
InterProi IPR004617. ApaH.
IPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
[Graphical view ]
Pfami PF00149. Metallophos. 1 hit.
[Graphical view ]
PIRSFi PIRSF000903. B5n-ttraPtase_sm. 1 hit.
SUPFAMi SSF56300. SSF56300. 1 hit.
TIGRFAMsi TIGR00668. apaH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The complete genome sequence of Escherichia coli DH10B: insights into the biology of a laboratory workhorse."
    Durfee T., Nelson R., Baldwin S., Plunkett G. III, Burland V., Mau B., Petrosino J.F., Qin X., Muzny D.M., Ayele M., Gibbs R.A., Csorgo B., Posfai G., Weinstock G.M., Blattner F.R.
    J. Bacteriol. 190:2597-2606(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / DH10B.

Entry informationi

Entry nameiAPAH_ECODH
AccessioniPrimary (citable) accession number: B1XC50
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: May 20, 2008
Last modified: June 11, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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