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B1XC50 (APAH_ECODH) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 41. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Bis(5'-nucleosyl)-tetraphosphatase, symmetrical

EC=3.6.1.41
Alternative name(s):
Ap4A hydrolase
Diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase
Diadenosine tetraphosphatase
Gene names
Name:apaH
Ordered Locus Names:ECDH10B_0050
OrganismEscherichia coli (strain K12 / DH10B) [Complete proteome] [HAMAP]
Taxonomic identifier316385 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

Protein attributes

Sequence length280 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP By similarity. HAMAP-Rule MF_00199

Catalytic activity

P1,P(4)-bis(5'-adenosyl) tetraphosphate + H2O = 2 ADP. HAMAP-Rule MF_00199

Sequence similarities

Belongs to the Ap4A hydrolase family.

Ontologies

Keywords
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular_functionbis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 280280Bis(5'-nucleosyl)-tetraphosphatase, symmetrical HAMAP-Rule MF_00199
PRO_1000099323

Sequences

Sequence LengthMass (Da)Tools
B1XC50 [UniParc].

Last modified May 20, 2008. Version 1.
Checksum: BD6560C73446C1BB

FASTA28031,297
        10         20         30         40         50         60 
MATYLIGDVH GCYDELIALL HKVEFTPGKD TLWLTGDLVA RGPGSLDVLR YVKSLGDSVR 

        70         80         90        100        110        120 
LVLGNHDLHL LAVFAGISRN KPKDRLTPLL EAPDADELLN WLRRQPLLQI DEEKKLVMAH 

       130        140        150        160        170        180 
AGITPQWDLQ TAKECARDVE AVLSSDSYPF FLDAMYGDMP NNWSPELRGL GRLRFITNAF 

       190        200        210        220        230        240 
TRMRFCFPNG QLDMYSKESP EEAPAPLKPW FAIPGPVAEE YSIAFGHWAS LEGKGTPEGI 

       250        260        270        280 
YALDTGCCWG GTLTCLRWED KQYFVQPSNR HKDLGEAAAS 

« Hide

References

[1]"The complete genome sequence of Escherichia coli DH10B: insights into the biology of a laboratory workhorse."
Durfee T., Nelson R., Baldwin S., Plunkett G. III, Burland V., Mau B., Petrosino J.F., Qin X., Muzny D.M., Ayele M., Gibbs R.A., Csorgo B., Posfai G., Weinstock G.M., Blattner F.R.
J. Bacteriol. 190:2597-2606(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / DH10B.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000948 Genomic DNA. Translation: ACB01254.1.
RefSeqYP_001729032.1. NC_010473.1.

3D structure databases

ProteinModelPortalB1XC50.
SMRB1XC50. Positions 2-268.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING316385.ECDH10B_0050.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACB01254; ACB01254; ECDH10B_0050.
GeneID6060780.
KEGGecd:ECDH10B_0050.
PATRIC18459848. VBIEscCol59506_0051.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0639.
HOGENOMHOG000251871.
KOK01525.
OMAWLRHQPL.
OrthoDBEOG66B3WP.
ProtClustDBPRK00166.

Enzyme and pathway databases

BioCycECOL316385:GJ8B-50-MONOMER.

Family and domain databases

HAMAPMF_00199. ApaH.
InterProIPR004617. ApaH.
IPR004843. Calcineurin-like_PHP_apaH.
[Graphical view]
PfamPF00149. Metallophos. 1 hit.
[Graphical view]
PIRSFPIRSF000903. B5n-ttraPtase_sm. 1 hit.
TIGRFAMsTIGR00668. apaH. 1 hit.
ProtoNetSearch...

Entry information

Entry nameAPAH_ECODH
AccessionPrimary (citable) accession number: B1XC50
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: May 20, 2008
Last modified: April 16, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families