B1XC35 (LAMB_ECODH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Maltoporin

Alternative name(s):
Maltose-inducible porin

Gene names

Name:	lamB
Ordered Locus Names:	ECDH10B_4225

Organism

Escherichia coli (strain K12 / DH10B) [Complete proteome] [HAMAP]

Taxonomic identifier

316385 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia › Escherichia coli › Escherichia coli (strain K12)

Protein attributes

Sequence length	446 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in the transport of maltose and maltodextrins By similarity. HAMAP-Rule MF_01301
Subunit structure	Homotrimer formed of three 18-stranded antiparallel beta-barrels, containing three independent channels By similarity.
Subcellular location	Cell outer membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01301.
Induction	By maltose Potential. HAMAP-Rule MF_01301
Sequence similarities	Belongs to the porin LamB (TC 1.B.3) family. [View classification]

Ontologies

Keywords
Biological process	Ion transport Sugar transport Transport
Cellular component	Cell membrane Cell outer membrane Membrane
Domain	Signal Transmembrane Transmembrane beta strand
Molecular function	Porin
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	ion transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cell outer membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW pore complex Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	maltodextrin transmembrane transporter activity Inferred from electronic annotation. Source: InterPro maltose transporting porin activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 25	25	Potential
	Chain	26 – 446	421	Maltoporin HAMAP-Rule MF_01301		PRO_1000140484
Sites
	Site	31	1	Greasy slide, important in sugar transport By similarity
	Site	66	1	Greasy slide, important in sugar transport By similarity
	Site	99	1	Greasy slide, important in sugar transport By similarity
	Site	143	1	Important in sugar transport By similarity
	Site	252	1	Greasy slide, important in sugar transport By similarity
	Site	383	1	Greasy slide, important in sugar transport By similarity
	Site	445	1	Greasy slide, important in sugar transport By similarity

Sequences

	Sequence		Length	Mass (Da)
	B1XC35 [UniParc]. Last modified May 20, 2008. Version 1. Checksum: B2D4E4F120DA494E	FASTA	446	49,912
	10 20 30 40 50 60 MMITLRKLPL AVAVAAGVMS AQAMAVDFHG YARSGIGWTG SGGEQQCFQT TGAQSKYRLG 70 80 90 100 110 120 NECETYAELK LGQEVWKEGD KSFYFDTNVA YSVAQQNDWE ATDPAFREAN VQGKNLIEWL 130 140 150 160 170 180 PGSTIWAGKR FYQRHDVHMI DFYYWDISGP GAGLENIDVG FGKLSLAATR SSEAGGSSSF 190 200 210 220 230 240 ASNNIYDYTN ETANDVFDVR LAQMEINPGG TLELGVDYGR ANLRDNYRLV DGASKDGWLF 250 260 270 280 290 300 TAEHTQSVLK GFNKFVVQYA TDSMTSQGKG LSQGSGVAFD NEKFAYNINN NGHMLRILDH 310 320 330 340 350 360 GAISMGDNWD MMYVGMYQDI NWDNDNGTKW WTVGIRPMYK WTPIMSTVME IGYDNVESQR 370 380 390 400 410 420 TGDKNNQYKI TLAQQWQAGD SIWSRPAIRV FATYAKWDEK WGYDYTGNAD NNANFGKAVP 430 440 ADFNGGSFGR GDSDEWTFGA QMEIWW

References

[1]

"The complete genome sequence of Escherichia coli DH10B: insights into the biology of a laboratory workhorse." Durfee T., Nelson R., Baldwin S., Plunkett G. III, Burland V., Mau B., Petrosino J.F., Qin X., Muzny D.M., Ayele M., Gibbs R.A., Csorgo B., Posfai G., Weinstock G.M., Blattner F.R. J. Bacteriol. 190:2597-2606(2008) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / DH10B.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000948 Genomic DNA. Translation: ACB05035.1.
RefSeq	YP_001732813.1. NC_010473.1.
3D structure databases
ProteinModelPortal	B1XC35.
SMR	B1XC35. Positions 26-446.
ModBase	Search...
Protein-protein interaction databases
STRING	316385.ECDH10B_4225.
Proteomic databases
PRIDE	B1XC35.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACB05035; ACB05035; ECDH10B_4225.
GeneID	6060514.
KEGG	ecd:ECDH10B_4225.
PATRIC	18468459. VBIEscCol59506_4254.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG4580.
HOGENOM	HOG000218083.
KO	K02024.
OMA	DYGRANA.
ProtClustDB	PRK09360.
Enzyme and pathway databases
BioCyc	ECOL316385:GJ8B-4046-MONOMER.
Family and domain databases
Gene3D	2.40.170.10. 1 hit.
HAMAP	MF_01301. LamB.
InterPro	IPR023738. Maltoporin. IPR003192. Porin_LamB. [Graphical view]
Pfam	PF02264. LamB. 1 hit. [Graphical view]
ProDom	PD008788. Porin_LamB. 1 hit. [Graphical view] [Entries sharing at least one domain]
ProtoNet	Search...

Entry information

Entry name

LAMB_ECODH

Accession

Primary (citable) accession number: B1XC35

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	May 20, 2008
Last modified:	May 1, 2013
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program