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B1XC18 (B1XC18_ECODH) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein names
Gene names
Name:metH EMBL ACB05018.1
Ordered Locus Names:ECDH10B_4208 EMBL ACB05018.1
OrganismEscherichia coli (strain K12 / DH10B) [Complete proteome] [HAMAP] EMBL ACB05018.1
Taxonomic identifier316385 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

Protein attributes

Sequence length1227 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Cofactor

Binds 1 zinc ion per subunit By similarity.

Cobalamin By similarity. PIRSR PIRSR000381-2

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region834 – 8352Cobalamin-binding By similarity
Region1189 – 11902S-adenosyl-L-methionine binding By similarity

Sites

Metal binding2471Zinc By similarity PIRSR PIRSR000381-1
Metal binding3101Zinc By similarity PIRSR PIRSR000381-1
Metal binding3111Zinc By similarity PIRSR PIRSR000381-1
Metal binding7591Cobalt (cobalamin axial ligand) By similarity PIRSR PIRSR000381-1
Binding site9461S-adenosyl-L-methionine By similarity
Binding site11341S-adenosyl-L-methionine; via carbonyl oxygen By similarity
Binding site11381Cobalamin; via carbonyl oxygen By similarity

Sequences

Sequence LengthMass (Da)Tools
B1XC18 [UniParc].

Last modified May 20, 2008. Version 1.
Checksum: 91F0CAA1E9127D9A

FASTA1,227135,997
        10         20         30         40         50         60 
MSSKVEQLRA QLNERILVLD GGMGTMIQSY RLNEADFRGE RFADWPCDLK GNNDLLVLSK 

        70         80         90        100        110        120 
PEVIAAIHNA YFEAGADIIE TNTFNSTTIA MADYQMESLS AEINFAAAKL ARACADEWTA 

       130        140        150        160        170        180 
RTPEKPRYVA GVLGPTNRTA SISPDVNDPA FRNITFDGLV AAYRESTKAL VEGGADLILI 

       190        200        210        220        230        240 
ETVFDTLNAK AAVFAVKTEF EALGVELPIM ISGTITDASG RTLSGQTTEA FYNSLRHAEA 

       250        260        270        280        290        300 
LTFGLNCALG PDELRQYVQE LSRIAECYVT AHPNAGLPNA FGEYDLDADT MAKQIREWAQ 

       310        320        330        340        350        360 
AGFLNIVGGC CGTTPQHIAA MSRAVEGLAP RKLPEIPVAC RLSGLEPLNI GEDSLFVNVG 

       370        380        390        400        410        420 
ERTNVTGSAK FKRLIKEEKY SEALDVARQQ VENGAQIIDI NMDEGMLDAE AAMVRFLNLI 

       430        440        450        460        470        480 
AGEPDIARVP IMIDSSKWDV IEKGLKCIQG KGIVNSISMK EGVDAFIHHA KLLRRYGAAV 

       490        500        510        520        530        540 
VVMAFDEQGQ ADTRARKIEI CRRAYKILTE EVGFPPEDII FDPNIFAVAT GIEEHNNYAQ 

       550        560        570        580        590        600 
DFIGACEDIK RELPHALISG GVSNVSFSFR GNDPVREAIH AVFLYYAIRN GMDMGIVNAG 

       610        620        630        640        650        660 
QLAIYDDLPA ELRDAVEDVI LNRRDDGTER LLELAEKYRG SKTDDTANAQ QAEWRSWEVN 

       670        680        690        700        710        720 
KRLEYSLVKG ITEFIEQDTE EARQQATRPI EVIEGPLMDG MNVVGDLFGE GKMFLPQVVK 

       730        740        750        760        770        780 
SARVMKQAVA YLEPFIEASK EQGKTNGKMV IATVKGDVHD IGKNIVGVVL QCNNYEIVDL 

       790        800        810        820        830        840 
GVMVPAEKIL RTAKEVNADL IGLSGLITPS LDEMVNVAKE MERQGFTIPL LIGGATTSKA 

       850        860        870        880        890        900 
HTAVKIEQNY SGPTVYVQNA SRTVGVVAAL LSDTQRDDFV ARTRKEYETV RIQHGRKKPR 

       910        920        930        940        950        960 
TPPVTLEAAR DNDFAFDWQA YTPPVAHRLG VQEVEASIET LRNYIDWTPF FMTWSLAGKY 

       970        980        990       1000       1010       1020 
PRILEDEVVG VEAQRLFKDA NDMLDKLSAE KTLNPRGVVG LFPANRVGDD IEIYRDETRT 

      1030       1040       1050       1060       1070       1080 
HVINVSHHLR QQTEKTGFAN YCLADFVAPK LSGKADYIGA FAVTGGLEED ALADAFEAQH 

      1090       1100       1110       1120       1130       1140 
DDYNKIMVKA LADRLAEAFA EYLHERVRKV YWGYAPNENL SNEELIRENY QGIRPAPGYP 

      1150       1160       1170       1180       1190       1200 
ACPEHTEKAT IWELLEVEKH TGMKLTESFA MWPGASVSGW YFSHPDSKYY AVAQIQRDQV 

      1210       1220 
EDYARRKGMS VTEVERWLAP NLGYDAD 

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References

[1]"The complete genome sequence of Escherichia coli DH10B: insights into the biology of a laboratory workhorse."
Durfee T., Nelson R., Baldwin S., Plunkett G.III., Burland V., Mau B., Petrosino J.F., Qin X., Muzny D.M., Ayele M., Gibbs R.A., Csorgo B., Posfai G., Weinstock G.M., Blattner F.R.
J. Bacteriol. 190:2597-2606(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / DH10B.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000948 Genomic DNA. Translation: ACB05018.1.
RefSeqYP_001732796.1. NC_010473.1.

3D structure databases

ProteinModelPortalB1XC18.
SMRB1XC18. Positions 12-1227.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING316385.ECDH10B_4208.

Proteomic databases

PRIDEB1XC18.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACB05018; ACB05018; ECDH10B_4208.
GeneID6059383.
KEGGecd:ECDH10B_4208.
PATRIC18468421. VBIEscCol59506_4235.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1410.
HOGENOMHOG000251409.
KOK00548.
OMASMKEGEA.
OrthoDBEOG6091CH.
ProtClustDBPRK09490.

Enzyme and pathway databases

BioCycECOL316385:GJ8B-4029-MONOMER.

Family and domain databases

Gene3D1.10.1240.10. 1 hit.
3.10.196.10. 1 hit.
3.20.20.20. 1 hit.
3.20.20.330. 1 hit.
3.40.50.280. 1 hit.
InterProIPR003759. Cbl-bd_cap.
IPR006158. Cobalamin-bd.
IPR011005. Dihydropteroate_synth-like.
IPR011822. MetH.
IPR000489. Pterin-binding.
IPR003726. S_MeTrfase.
IPR004223. VitB12-dep_Met_synth_activ_dom.
[Graphical view]
PfamPF02310. B12-binding. 1 hit.
PF02607. B12-binding_2. 1 hit.
PF02965. Met_synt_B12. 1 hit.
PF00809. Pterin_bind. 1 hit.
PF02574. S-methyl_trans. 1 hit.
[Graphical view]
PIRSFPIRSF000381. MetH. 1 hit.
SMARTSM01018. B12-binding_2. 1 hit.
[Graphical view]
SUPFAMSSF47644. SSF47644. 1 hit.
SSF51717. SSF51717. 1 hit.
SSF52242. SSF52242. 1 hit.
SSF56507. SSF56507. 1 hit.
SSF82282. SSF82282. 1 hit.
TIGRFAMsTIGR02082. metH. 1 hit.
PROSITEPS50974. ADOMET_ACTIVATION. 1 hit.
PS51332. B12_BINDING. 1 hit.
PS51337. B12_BINDING_NTER. 1 hit.
PS50970. HCY. 1 hit.
PS50972. PTERIN_BINDING. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameB1XC18_ECODH
AccessionPrimary (citable) accession number: B1XC18
Entry history
Integrated into UniProtKB/TrEMBL: May 20, 2008
Last sequence update: May 20, 2008
Last modified: April 16, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)