B1X1D7 (B1X1D7_CYAA5) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Acetyl-coenzyme A synthetase HAMAP MF_01123
EC=6.2.1.1 HAMAP MF_01123

Alternative name(s):
Acetate--CoA ligase HAMAP MF_01123
Acyl-activating enzyme HAMAP MF_01123

Gene names

Name:	acs EMBL ACB51366.1
Synonyms:	acsA HAMAP MF_01123
Ordered Locus Names:	cce_2016

Organism

Cyanothece sp. (strain ATCC 51142) [Complete proteome] [HAMAP]

Taxonomic identifier

43989 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Chroococcales › Cyanothece

Protein attributes

Sequence length	665 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA. HAMAP MF_01123
Post-translational modification	Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme By similarity. HAMAP MF_01123
Sequence similarities	Belongs to the ATP-dependent AMP-binding enzyme family. HAMAP MF_01123

Ontologies

Keywords
Ligand	ATP-binding HAMAP MF_01123 Nucleotide-binding
Molecular function	Ligase HAMAP MF_01123
PTM	Acetylation HAMAP MF_01123
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	AMP binding Inferred from electronic annotation. Source: InterPro ATP binding Inferred from electronic annotation. Source: UniProtKB-KW acetate-CoA ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	538	1	By similarity HAMAP MF_01123
Amino acid modifications
	Modified residue	630	1	N6-acetyllysine By similarity HAMAP MF_01123

Sequences

	Sequence		Length	Mass (Da)
	B1X1D7 [UniParc]. Last modified May 20, 2008. Version 1. Checksum: 2E07EF5E6D773803	FASTA	665	74,494
	10 20 30 40 50 60 MLRSIVMVAS SEKNNIESVL QEKRVFNPPA DFATNAHIKS LQQYEELYEK AKNDPETFWA 70 80 90 100 110 120 ELAEQELYWF EKWDQVLDWN PPTAKWFVNG KLNMSYNCLD RHLTTWRRNK AAIIWEGEPG 130 140 150 160 170 180 DSRTLTYGEL HREVCQFANV LKDMGVQKGD RVGIYMPMVP EAAIAMLACT RIGAPHSVVF 190 200 210 220 230 240 GGFSAEALRD RLEDAEAKVV ITADGGFRKD KIVPLKIEVD QALENGASSV EKVIVVQRTK 250 260 270 280 290 300 QDVTMREGRD YWWHDLQKDA SPKCDAEVMD SEDPLFILYT SGSTGKPKGV VHTTGGYNLY 310 320 330 340 350 360 THMTTKWIFD LKDTDVYWCT ADVGWITGHS YIVYGPLSNG ATSLMYEGVP RPSNPGCFWD 370 380 390 400 410 420 VVEKYGVNVF YTAPTAIRAF MKMGEELPNA RDLSSLRLLG TVGEPINPEA WMWYHRVIGG 430 440 450 460 470 480 EKCPIVDTWW QTETGGIMIT PLPGATPTKP GSATRPFPGI IADVVDKDGN PVPNNAGGYL 490 500 510 520 530 540 VIKHPWPSML RTVYNNPERF QKTYWDPIPE VEGKPVYFAG DSARKDENGY FWIMGRTDDV 550 560 570 580 590 600 MNVSGHRLGS MELESALVSH PAVAEASVVG VPHEIKGEDI YAFVTLKDNY SPSDELNKEL 610 620 630 640 650 660 KQHVVTKISA IARPGTIQFA EALPKTRSGK IVRRFLRQIA AGQDIVGDKS TVVDPSVLDQ LREKG

References

[1]

"The genome of Cyanothece 51142, a unicellular diazotrophic cyanobacterium important in the marine nitrogen cycle." Welsh E.A., Liberton M., Stoeckel J., Loh T., Elvitigala T., Wang C., Wollam A., Fulton R.S., Clifton S.W., Jacobs J.M., Aurora R., Ghosh B.K., Sherman L.A., Smith R.D., Wilson R.K., Pakrasi H.B. Proc. Natl. Acad. Sci. U.S.A. 105:15094-15099(2008) [PubMed: 18812508] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000806 Genomic DNA. Translation: ACB51366.1.
RefSeq	YP_001803432.1. NC_010546.1.
3D structure databases
ProteinModelPortal	B1X1D7.
ModBase	Search...
Protein-protein interaction databases
STRING	B1X1D7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6169070.
GenomeReviews	Gene locus cce_2016 in contig CP000806_GR.
KEGG	cyt:cce_2016.
PATRIC	21542487. VBICyaSp130209_2068.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG547964.
OMA	VISVSGH.
PhylomeDB	B1X1D7.
ProtClustDB	PRK00174.
Family and domain databases
HAMAP	MF_01123. Ac_CoA_synth. [Tree]
InterPro	IPR011904. Ac_CoA_lig. IPR024597. Acyl-CoA_synth_DUF3448. IPR020845. AMP-binding_CS. IPR000873. AMP-dep_Synth/Lig. [Graphical view]
KO	K01895.
PANTHER	PTHR24095:SF42. PTHR24095:SF42. 1 hit.
Pfam	PF00501. AMP-binding. 1 hit. PF11930. DUF3448. 1 hit. [Graphical view]
TIGRFAMs	TIGR02188. Ac_CoA_lig_AcsA. 1 hit.
PROSITE	PS00455. AMP_BINDING. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

B1X1D7_CYAA5

Accession

Primary (citable) accession number: B1X1D7

Entry history

Integrated into UniProtKB/TrEMBL:	May 20, 2008
Last sequence update:	May 20, 2008
Last modified:	December 14, 2011
This is version 24 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)