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B1X023

- GSA_CYAA5

UniProt

B1X023 - GSA_CYAA5

Protein

Glutamate-1-semialdehyde 2,1-aminomutase

Gene

hemL

Organism
Cyanothece sp. (strain ATCC 51142)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 51 (01 Oct 2014)
      Sequence version 2 (01 Sep 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    (S)-4-amino-5-oxopentanoate = 5-aminolevulinate.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. glutamate-1-semialdehyde 2,1-aminomutase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: InterPro
    3. transaminase activity Source: InterPro

    GO - Biological processi

    1. chlorophyll biosynthetic process Source: UniProtKB-HAMAP
    2. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Chlorophyll biosynthesis, Porphyrin biosynthesis

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciCSP43989:GKC8-175-MONOMER.
    UniPathwayiUPA00251; UER00317.
    UPA00668.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamate-1-semialdehyde 2,1-aminomutaseUniRule annotation (EC:5.4.3.8UniRule annotation)
    Short name:
    GSAUniRule annotation
    Alternative name(s):
    Glutamate-1-semialdehyde aminotransferaseUniRule annotation
    Short name:
    GSA-ATUniRule annotation
    Gene namesi
    Name:hemLUniRule annotation
    Ordered Locus Names:cce_0172
    OrganismiCyanothece sp. (strain ATCC 51142)
    Taxonomic identifieri43989 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesCyanothece
    ProteomesiUP000001203: Chromosome circular

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 433433Glutamate-1-semialdehyde 2,1-aminomutasePRO_0000382301Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei273 – 2731N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi43989.cce_0172.

    Structurei

    3D structure databases

    ProteinModelPortaliB1X023.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0001.
    HOGENOMiHOG000020210.
    KOiK01845.
    OrthoDBiEOG6QVRHN.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 2 hits.
    HAMAPiMF_00375. HemL_aminotrans_3.
    InterProiIPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
    IPR005814. Aminotrans_3.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PANTHERiPTHR11986. PTHR11986. 1 hit.
    PfamiPF00202. Aminotran_3. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
    SUPFAMiSSF53383. SSF53383. 1 hit.
    TIGRFAMsiTIGR00713. hemL. 1 hit.
    PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B1X023-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVSTTSLKTT KSEDIFAAAQ KLMPGGVSSP VRAFKSVGGQ PIVFDHVKGA    50
    YIWDVDGNQY IDYVGTWGPA ICGHAHPEVI AALHDALDRG TSFGAPCLLE 100
    NVLAEMVIDA VPSIEMVRFV NSGTEACMSV LRLMRAFTGR DKIIKFQGCY 150
    HGHADMFLVQ AGSGVATLGL PDSPGVPKTT TANTLTAPYN DLEAVKALFA 200
    ENPDEIAGVI LEPVVGNSGF VVPDGGFLQG LRELTNEYGA LLVFDEVMTG 250
    FRLSYGGAQE KFGVTPDLTT LGKVIGGGLP VGAYGGRKDI MSMVAPAGPM 300
    YQAGTLSGNP LAMTAGIKTL ELLQKPGTYN QLEQITQQLS EGLLKIAKEA 350
    GHQVCGGYIG AMFGLFFTEG PVRNYDDAKK SDLAKFGRFH RGMLEKGVYL 400
    APSQFEAGFT SLAHTSEDIE KTLAAAKDVL SNL 433
    Length:433
    Mass (Da):45,913
    Last modified:September 1, 2009 - v2
    Checksum:iE1D73868664AB4C0
    GO

    Sequence cautioni

    The sequence ACB49524.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000806 Genomic DNA. Translation: ACB49524.1. Different initiation.
    RefSeqiWP_009543036.1. NC_010546.1.
    YP_001801590.1. NC_010546.1.

    Genome annotation databases

    EnsemblBacteriaiACB49524; ACB49524; cce_0172.
    GeneIDi6167138.
    KEGGicyt:cce_0172.
    PATRICi21538806. VBICyaSp130209_0254.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000806 Genomic DNA. Translation: ACB49524.1 . Different initiation.
    RefSeqi WP_009543036.1. NC_010546.1.
    YP_001801590.1. NC_010546.1.

    3D structure databases

    ProteinModelPortali B1X023.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 43989.cce_0172.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACB49524 ; ACB49524 ; cce_0172 .
    GeneIDi 6167138.
    KEGGi cyt:cce_0172.
    PATRICi 21538806. VBICyaSp130209_0254.

    Phylogenomic databases

    eggNOGi COG0001.
    HOGENOMi HOG000020210.
    KOi K01845.
    OrthoDBi EOG6QVRHN.

    Enzyme and pathway databases

    UniPathwayi UPA00251 ; UER00317 .
    UPA00668 .
    BioCyci CSP43989:GKC8-175-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 2 hits.
    HAMAPi MF_00375. HemL_aminotrans_3.
    InterProi IPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
    IPR005814. Aminotrans_3.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    PANTHERi PTHR11986. PTHR11986. 1 hit.
    Pfami PF00202. Aminotran_3. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
    SUPFAMi SSF53383. SSF53383. 1 hit.
    TIGRFAMsi TIGR00713. hemL. 1 hit.
    PROSITEi PS00600. AA_TRANSFER_CLASS_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 51142.

    Entry informationi

    Entry nameiGSA_CYAA5
    AccessioniPrimary (citable) accession number: B1X023
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 1, 2009
    Last sequence update: September 1, 2009
    Last modified: October 1, 2014
    This is version 51 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3