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Protein

1,4-dihydroxy-2-naphthoyl-CoA hydrolase

Gene

cce_1832

Organism
Cyanothece sp. (strain ATCC 51142)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the hydrolysis of 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA) to 1,4-dihydroxy-2-naphthoate (DHNA), a reaction involved in phylloquinone (vitamin K1) biosynthesis.UniRule annotation

Catalytic activityi

1,4-dihydroxy-2-naphthoyl-CoA + H2O = 1,4-dihydroxy-2-naphthoate + CoA.UniRule annotation

Pathwayi: phylloquinone biosynthesis

This protein is involved in the pathway phylloquinone biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway phylloquinone biosynthesis and in Cofactor biosynthesis.

Pathwayi: 1,4-dihydroxy-2-naphthoate biosynthesis

This protein is involved in step 7 of the subpathway that synthesizes 1,4-dihydroxy-2-naphthoate from chorismate.UniRule annotation
Proteins known to be involved in the 7 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase (menD)
  3. no protein annotated in this organism
  4. o-succinylbenzoate synthase (menC)
  5. no protein annotated in this organism
  6. 1,4-dihydroxy-2-naphthoyl-CoA synthase (menB)
  7. 1,4-dihydroxy-2-naphthoyl-CoA hydrolase (cce_1832)
This subpathway is part of the pathway 1,4-dihydroxy-2-naphthoate biosynthesis, which is itself part of Quinol/quinone metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 1,4-dihydroxy-2-naphthoate from chorismate, the pathway 1,4-dihydroxy-2-naphthoate biosynthesis and in Quinol/quinone metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei13 – 131UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciCSP43989:GKC8-1860-MONOMER.
UniPathwayiUPA00995.
UPA01057; UER01033.

Names & Taxonomyi

Protein namesi
Recommended name:
1,4-dihydroxy-2-naphthoyl-CoA hydrolaseUniRule annotation (EC:3.1.2.28UniRule annotation)
Short name:
DHNA-CoA hydrolaseUniRule annotation
Alternative name(s):
DHNA-CoA thioesteraseUniRule annotation
Gene namesi
Ordered Locus Names:cce_1832
OrganismiCyanothece sp. (strain ATCC 51142)
Taxonomic identifieri43989 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesCyanothece
Proteomesi
  • UP000001203 Componenti: Chromosome circular

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 1371371,4-dihydroxy-2-naphthoyl-CoA hydrolasePRO_0000377010Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi43989.cce_1832.

Structurei

3D structure databases

ProteinModelPortaliB1WZN0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the 4-hydroxybenzoyl-CoA thioesterase family. DHNA-CoA hydrolase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105WGP. Bacteria.
COG0824. LUCA.
HOGENOMiHOG000056134.
KOiK12073.
OMAiHEAWEES.
OrthoDBiPOG091H02B8.

Family and domain databases

Gene3Di3.10.129.10. 1 hit.
HAMAPiMF_02101. DHNA_CoA_hydrolase. 1 hit.
InterProiIPR022829. DHNA_CoA_hydrolase.
IPR029069. HotDog_dom.
[Graphical view]
SUPFAMiSSF54637. SSF54637. 1 hit.

Sequencei

Sequence statusi: Complete.

B1WZN0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTYNRTIHFS DTDAAGVVYF AAFLSICHEA YENSLQVAGI DLKTFFTSSD
60 70 80 90 100
IAIPIVHADI DFYQPLFCGD RIQINLTPTQ LNETEFEIKY QVFNENNLDK
110 120 130
LIAKATTKHV SINPKIRQRT SLSLSITQWL RSNQDDC
Length:137
Mass (Da):15,640
Last modified:May 20, 2008 - v1
Checksum:i62F8BA4AF76E97AD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000806 Genomic DNA. Translation: ACB51182.1.
RefSeqiWP_009545645.1. NC_010546.1.

Genome annotation databases

EnsemblBacteriaiACB51182; ACB51182; cce_1832.
KEGGicyt:cce_1832.
PATRICi21542119. VBICyaSp130209_1889.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000806 Genomic DNA. Translation: ACB51182.1.
RefSeqiWP_009545645.1. NC_010546.1.

3D structure databases

ProteinModelPortaliB1WZN0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi43989.cce_1832.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACB51182; ACB51182; cce_1832.
KEGGicyt:cce_1832.
PATRICi21542119. VBICyaSp130209_1889.

Phylogenomic databases

eggNOGiENOG4105WGP. Bacteria.
COG0824. LUCA.
HOGENOMiHOG000056134.
KOiK12073.
OMAiHEAWEES.
OrthoDBiPOG091H02B8.

Enzyme and pathway databases

UniPathwayiUPA00995.
UPA01057; UER01033.
BioCyciCSP43989:GKC8-1860-MONOMER.

Family and domain databases

Gene3Di3.10.129.10. 1 hit.
HAMAPiMF_02101. DHNA_CoA_hydrolase. 1 hit.
InterProiIPR022829. DHNA_CoA_hydrolase.
IPR029069. HotDog_dom.
[Graphical view]
SUPFAMiSSF54637. SSF54637. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiDNCH_CYAA5
AccessioniPrimary (citable) accession number: B1WZN0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 16, 2009
Last sequence update: May 20, 2008
Last modified: September 7, 2016
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.