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B1WXU7 (B1WXU7_CYAA5) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 29. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-oxoacyl-[acyl-carrier-protein] synthase 3 HAMAP MF_01815
EC=2.3.1.180 HAMAP MF_01815
Alternative name(s):
3-oxoacyl-[acyl-carrier-protein] synthase III HAMAP MF_01815
Beta-ketoacyl-ACP synthase III HAMAP MF_01815
Gene names
Name:fabH HAMAP MF_01815 EMBL ACB50934.1
Ordered Locus Names:cce_1584
OrganismCyanothece sp. (strain ATCC 51142) [Complete proteome] [HAMAP]
Taxonomic identifier43989 [NCBI]
Taxonomic lineageBacteria › Cyanobacteria › Chroococcales › Cyanothece

Protein attributes

Sequence length331 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids By similarity. HAMAP MF_01815

Catalytic activity

Acetyl-CoA + malonyl-[acyl-carrier-protein] = acetoacetyl-[acyl-carrier-protein] + CoA + CO2. HAMAP MF_01815

Pathway

Lipid metabolism; fatty acid biosynthesis. HAMAP MF_01815 SAAS SAAS013747

Subunit structure

Homodimer By similarity. HAMAP MF_01815 SAAS SAAS013747

Subcellular location

Cytoplasm By similarity HAMAP MF_01815 SAAS SAAS013747.

Domain

The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH By similarity. HAMAP MF_01815

Sequence similarities

Belongs to the FabH family. HAMAP MF_01815

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region257 – 2615ACP-binding By similarity HAMAP MF_01815

Sites

Active site1141 By similarity HAMAP MF_01815
Active site2561 By similarity HAMAP MF_01815
Active site2861 By similarity HAMAP MF_01815

Sequences

Sequence LengthMass (Da)Tools
B1WXU7 [UniParc].

Last modified May 20, 2008. Version 1.
Checksum: 40D807EA5AA238AD

FASTA33135,379
        10         20         30         40         50         60 
MKAIGVSIIG CGSAAPKQVM TNDDLSRLVE TSDEWIRTRT GIRKRHLATT NSSLSDLSAQ 

        70         80         90        100        110        120 
AATEAIAMAG LVPGDIDLII LATSTADDLF GSAAKIQHIL EANNAVAFDL TAACSGFVFG 

       130        140        150        160        170        180 
LITAAQYIRT GVYQNVLVIG ADILSRWVDW SDRTTCVLFG DGAGAVVCQG ITDHDNLLGF 

       190        200        210        220        230        240 
AMYSDGKQHD ALNLGYHGND KELKEGIAIN QGTYQPITMK GRDVYRFAVE KVPEVIEKAL 

       250        260        270        280        290        300 
FNAHLTTDDI DWLILHQANQ RIIDAVAKRL KIPSQKVIAN LDEYGNTSAA SIPLALDEAV 

       310        320        330 
GQGKIKSGDI VATSGFGAGL TWGAAIFRWG I

« Hide

References

[1]"The genome of Cyanothece 51142, a unicellular diazotrophic cyanobacterium important in the marine nitrogen cycle."
Welsh E.A., Liberton M., Stoeckel J., Loh T., Elvitigala T., Wang C., Wollam A., Fulton R.S., Clifton S.W., Jacobs J.M., Aurora R., Ghosh B.K., Sherman L.A., Smith R.D., Wilson R.K., Pakrasi H.B.
Proc. Natl. Acad. Sci. U.S.A. 105:15094-15099(2008) [PubMed: 18812508] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000806 Genomic DNA. Translation: ACB50934.1.
RefSeqYP_001803000.1. NC_010546.1.

3D structure databases

ProteinModelPortalB1WXU7.
ModBaseSearch...

Protein-protein interaction databases

STRINGB1WXU7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6168632.
GenomeReviewsGene locus cce_1584 in contig CP000806_GR.
KEGGcyt:cce_1584.
PATRIC21541637. VBICyaSp130209_1648.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG649927.
OMAFNAKEEA.
PhylomeDBB1WXU7.
ProtClustDBCLSK2332636.

Family and domain databases

HAMAPMF_01815. FabH.
[Tree]
InterProIPR013751. ACP_syn_III.
IPR013747. ACP_syn_III_C.
IPR004655. FabH_synth.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
Gene3DG3DSA:3.40.47.10. Thiolase-like_subgr. 2 hits.
KOK00648.
PfamPF08545. ACP_syn_III. 1 hit.
PF08541. ACP_syn_III_C. 1 hit.
[Graphical view]
SUPFAMSSF53901. Thiolase-like. 1 hit.
TIGRFAMsTIGR00747. FabH. 1 hit.
ProtoNetSearch...

Entry information

Entry nameB1WXU7_CYAA5
AccessionPrimary (citable) accession number: B1WXU7
Entry history
Integrated into UniProtKB/TrEMBL: May 20, 2008
Last sequence update: May 20, 2008
Last modified: December 14, 2011
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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