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Protein

Isocitrate dehydrogenase [NADP]

Gene

icd

Organism
Cyanothece sp. (strain ATCC 51142)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciCSP43989:GKC8-3242-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Name:icdImported
Ordered Locus Names:cce_3202Imported
OrganismiCyanothece sp. (strain ATCC 51142)Imported
Taxonomic identifieri43989 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesCyanothece
ProteomesiUP000001203 Componenti: Chromosome circular

Interactioni

Protein-protein interaction databases

STRINGi43989.cce_3202.

Structurei

3D structure databases

ProteinModelPortaliB1WXK9.
SMRiB1WXK9. Positions 31-495.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0538.
HOGENOMiHOG000021113.
KOiK00031.
OMAiRDWGYEL.
OrthoDBiEOG6SNDTP.

Family and domain databases

Gene3Di3.40.718.10. 2 hits.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B1WXK9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGELNRLGSV IKKQPLIIDH FMYEKLTPPT TGSKITFKDG KPIVPNDPIV
60 70 80 90 100
PFIRGDGTGV DIWPATEKVI DAAVKTAYGD SKKINWFKVY AGDEACDKYG
110 120 130 140 150
TYQYLPEDTL TAIREYGIAI KGPLTTPVGG GIRSLNVALR QIFELYACVR
160 170 180 190 200
PCRYYPGTPS PHKSPEKLDV IVYRENTEDI YLGIEWKEGT ELAQKLINYL
210 220 230 240 250
NNELIPATPE HGKKQIRLDS GIGVKPISKT GSQRLVRRAI EHALRLPKAK
260 270 280 290 300
QMVTLVHKGN IMKYTEGSFR DWGYELATSE FREVCVTERE SWILSNKEGN
310 320 330 340 350
ADISIEDNAR KVEPGYDGLT LDKKEEICGE VKGVLDAIWD SHGDGKWKDK
360 370 380 390 400
IMVNDRIADS IFQQIQTRPD EYSILATMNL NGDYLSDAAA AVVGGLGMGP
410 420 430 440 450
GANIGDTCAI FEATHGTAPK HAGLDRINPG SVILSGVMML EYMGWKEAAE
460 470 480 490
LIKKGIGNAI ANRQVTYDLA RLMEPKVDPP LKCSEFAQAI IDHFND
Length:496
Mass (Da):54,936
Last modified:May 20, 2008 - v1
Checksum:iAA93BA2BC59A0564
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000806 Genomic DNA. Translation: ACB52550.1.

Genome annotation databases

EnsemblBacteriaiACB52550; ACB52550; cce_3202.
KEGGicyt:cce_3202.
PATRICi21544800. VBICyaSp130209_3218.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000806 Genomic DNA. Translation: ACB52550.1.

3D structure databases

ProteinModelPortaliB1WXK9.
SMRiB1WXK9. Positions 31-495.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi43989.cce_3202.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACB52550; ACB52550; cce_3202.
KEGGicyt:cce_3202.
PATRICi21544800. VBICyaSp130209_3218.

Phylogenomic databases

eggNOGiCOG0538.
HOGENOMiHOG000021113.
KOiK00031.
OMAiRDWGYEL.
OrthoDBiEOG6SNDTP.

Enzyme and pathway databases

BioCyciCSP43989:GKC8-3242-MONOMER.

Family and domain databases

Gene3Di3.40.718.10. 2 hits.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51142Imported.

Entry informationi

Entry nameiB1WXK9_CYAA5
AccessioniPrimary (citable) accession number: B1WXK9
Entry historyi
Integrated into UniProtKB/TrEMBL: May 20, 2008
Last sequence update: May 20, 2008
Last modified: July 22, 2015
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.