B1WUL4 (B1WUL4_CYAA5) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Histidinol dehydrogenase PIRNR PIRNR000099
Short name=HDH PIRNR PIRNR000099
EC=1.1.1.23 PIRNR PIRNR000099

Gene names

Name:	hisD2 EMBL ACB53868.1
Ordered Locus Names:	cce_4520

Organism

Cyanothece sp. (strain ATCC 51142) [Complete proteome] [HAMAP]

Taxonomic identifier

43989 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Chroococcales › Cyanothece

Protein attributes

Sequence length	431 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity. PIRNR PIRNR000099 SAAS SAAS012131
Catalytic activity	L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH. PIRNR PIRNR000099 SAAS SAAS012131
Cofactor	Binds 1 zinc ion per subunit By similarity. SAAS SAAS022695
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9. PIRNR PIRNR000099 SAAS SAAS012131
Sequence similarities	Belongs to the histidinol dehydrogenase family. RuleBase RU004175 PIRNR PIRNR000099

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis PIRNR PIRNR000099 SAAS SAAS012131
Ligand	Metal-binding SAAS SAAS022695 NAD SAAS SAAS012131 PIRNR PIRNR000099 Zinc SAAS SAAS022695
Molecular function	Oxidoreductase PIRNR PIRNR000099 SAAS SAAS012131
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	histidine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	NAD binding Inferred from electronic annotation. Source: InterPro histidinol dehydrogenase activity Inferred from electronic annotation. Source: EC zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	B1WUL4 [UniParc]. Last modified May 20, 2008. Version 1. Checksum: 76C0BAA9827E7358	FASTA	431	47,001
	10 20 30 40 50 60 MLRIITQSAE INTELQRIRD RPYRDEIQAK EVAVGEILER IKHQGDQGLF EPFDILTTPT 70 80 90 100 110 120 NLKVSGSDLD AAYQKIPKEL LDAIQTVSQK LESFYKQQLP KPWVKFEDDD VVVGKRYTPV 130 140 150 160 170 180 KRAGIYVAWD QGSPISRVLM QTLPAKMAKV PEIILVTPPD ETGKVPPDIL VAAQVSGVNQ 190 200 210 220 230 240 IYRIGGAKAI AALAHGTETI PKVEVITGTG GLDVILAKRM VYGTVTTDTP VDASELFIIA 250 260 270 280 290 300 DRTANPAYVA ADLLAQVEQD PSSAVIVLTT DFSLAQKIQT KVQEKLQDNA HGILSEKAIA 310 320 330 340 350 360 HYSLIIIVES LEQAVNITNE FAPHYGMLAL TEPWDIIEKI RAVGSLFIGH NTPKAVGDYL 370 380 390 400 410 420 GTGSVILPPS GLIRYASSVR VETFLKPSHL IEYAPTALKK LANALEILAL AEGLPGTADA 430 INLRLVEGED Y

References

[1]

"The genome of Cyanothece 51142, a unicellular diazotrophic cyanobacterium important in the marine nitrogen cycle." Welsh E.A., Liberton M., Stoeckel J., Loh T., Elvitigala T., Wang C., Wollam A., Fulton R.S., Clifton S.W., Jacobs J.M., Aurora R., Ghosh B.K., Sherman L.A., Smith R.D., Wilson R.K., Pakrasi H.B. Proc. Natl. Acad. Sci. U.S.A. 105:15094-15099(2008) [PubMed: 18812508] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000806 Genomic DNA. Translation: ACB53868.1.
RefSeq	YP_001805934.1. NC_010546.1.
3D structure databases
ProteinModelPortal	B1WUL4.
ModBase	Search...
Protein-protein interaction databases
STRING	B1WUL4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6171598.
GenomeReviews	Gene locus cce_4520 in contig CP000806_GR.
KEGG	cyt:cce_4520.
PATRIC	21547380. VBICyaSp130209_4494.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG329596.
OMA	AMATASE.
PhylomeDB	B1WUL4.
ProtClustDB	CLSK2404961.
Family and domain databases
HAMAP	MF_01024. HisD. [Tree]
InterPro	IPR016161. Ald_DH/histidinol_DH. IPR022695. Histidinol_DH_monofunct. IPR012131. Hstdl_DH. [Graphical view]
KO	K00013.
PANTHER	PTHR21256:SF2. Hstdl_DH_prok. 1 hit.
Pfam	PF00815. Histidinol_dh. 1 hit. [Graphical view]
PIRSF	PIRSF000099. Histidinol_dh. 1 hit.
PRINTS	PR00083. HOLDHDRGNASE.
SUPFAM	SSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
TIGRFAMs	TIGR00069. HisD. 1 hit.
ProtoNet	Search...

Entry information

Entry name

B1WUL4_CYAA5

Accession

Primary (citable) accession number: B1WUL4

Entry history

Integrated into UniProtKB/TrEMBL:	May 20, 2008
Last sequence update:	May 20, 2008
Last modified:	December 14, 2011
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)